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Sympk symplekin [ Mus musculus (house mouse) ]

Gene ID: 68188, updated on 11-Apr-2024

Summary

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Official Symbol
Sympkprovided by MGI
Official Full Name
symplekinprovided by MGI
Primary source
MGI:MGI:1915438
See related
Ensembl:ENSMUSG00000023118 AllianceGenome:MGI:1915438
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SPK; SYM; 1500016F02Rik; 4632415H16Rik
Summary
Predicted to be involved in mRNA polyadenylation; negative regulation of protein binding activity; and positive regulation of protein dephosphorylation. Predicted to act upstream of or within cell adhesion and mRNA processing. Located in nuclear body. Is expressed in pancreas tip epithelium. Orthologous to human SYMPK (symplekin scaffold protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 36.3), ovary adult (RPKM 34.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 9.46 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (18758321..18788542)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19024377..19054623)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene interferon regulatory factor 2 binding protein 1 Neighboring gene forkhead box A3 Neighboring gene radial spoke head 6 homolog A (Chlamydomonas) Neighboring gene STARR-positive B cell enhancer ABC_E8152 Neighboring gene dystrophia myotonica-containing WD repeat motif

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SYMPK Is Required for Meiosis and Involved in Alternative Splicing in Male Germ Cells. Wu R, et al. Front Cell Dev Biol, 2021. PMID 34434935, Free PMC Article
  2. Interaction Between Sympk and Oct4 Promotes Mouse Embryonic Stem Cell Proliferation. Yu J, et al. Stem Cells, 2019 Jun. PMID 30801858
  3. Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation. Liu H, et al. Dev Cell, 2017 May 22. PMID 28535374, Free PMC Article
  4. Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex. Udagawa T, et al. Mol Cell, 2012 Jul 27. PMID 22727665, Free PMC Article
  5. Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles. Hilditch-Maguire P, et al. Hum Mol Genet, 2000 Nov 22. PMID 11092755

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
symplekin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360713.2 → NP_001347642.1  symplekin isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC170864
    UniProtKB/TrEMBL
    Q3TN10
    Conserved Domains (2) summary
    pfam11935
    Location:122 → 337
    DUF3453; Domain of unknown function (DUF3453)
    pfam12295
    Location:887 → 964
    Symplekin_C; Symplekin tight junction protein C terminal

  2. NM_026605.3 → NP_080881.2  symplekin isoform 1

    See identical proteins and their annotated locations for NP_080881.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC170864
    Consensus CDS
    CCDS52051.1
    UniProtKB/Swiss-Prot
    F8WJD4, Q80X82
    UniProtKB/TrEMBL
    Q3U2B5, Q3U2V0
    Related
    ENSMUSP00000023882.8, ENSMUST00000023882.14
    Conserved Domains (2) summary
    pfam11935
    Location:122 → 336
    DUF3453; Domain of unknown function (DUF3453)
    pfam12295
    Location:887 → 1068
    Symplekin_C; Symplekin tight junction protein C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    18758321..18788542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540332.4 → XP_006540395.1  symplekin isoform X1

    See identical proteins and their annotated locations for XP_006540395.1

    UniProtKB/Swiss-Prot
    F8WJD4, Q80X82
    UniProtKB/TrEMBL
    Q3U2B5, Q3U2V0
    Conserved Domains (2) summary
    pfam11935
    Location:122 → 336
    DUF3453; Domain of unknown function (DUF3453)
    pfam12295
    Location:887 → 1068
    Symplekin_C; Symplekin tight junction protein C terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80X82.2 GenPept UniProtKB/Swiss-Prot:Q80X82

Gene LinkOut

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