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Otub2 OTU domain, ubiquitin aldehyde binding 2 [ Mus musculus (house mouse) ]

Gene ID: 68149, updated on 5-Mar-2024

Summary

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Official Symbol
Otub2provided by MGI
Official Full Name
OTU domain, ubiquitin aldehyde binding 2provided by MGI
Primary source
MGI:MGI:1915399
See related
Ensembl:ENSMUSG00000021203 AllianceGenome:MGI:1915399
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OTB2; OTU2; 2010015L18Rik; 4930586I02Rik
Summary
Predicted to enable thiol-dependent deubiquitinase and ubiquitin binding activity. Predicted to be involved in negative regulation of nitrogen compound metabolic process and protein deubiquitination. Predicted to act upstream of or within proteolysis. Predicted to be active in nucleus. Orthologous to human OTUB2 (OTU deubiquitinase, ubiquitin aldehyde binding 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 80.7), liver E14 (RPKM 6.9) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Otub2 in Genome Data Viewer
Location:
12 E; 12 52.92 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103343244..103372609)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103376894..103406350)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 181, member A Neighboring gene predicted gene 29508 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:104569739-104569961 Neighboring gene ankyrin repeat and SOCS box-containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E4038 Neighboring gene STARR-positive B cell enhancer ABC_E1863 Neighboring gene predicted gene 15523 Neighboring gene STARR-positive B cell enhancer ABC_E7174 Neighboring gene DEAD box helicase 24 Neighboring gene STARR-positive B cell enhancer ABC_E4039 Neighboring gene predicted gene, 53758

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis. Chang W, et al. Cell Rep, 2022 Oct 25. PMID 36288705
  2. Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets. Beck A, et al. Diabetologia, 2013 Jun. PMID 23515685
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. siRNAs of OTUB2 impaired insulin secretion both under basal conditions and in cytokine-treated MIN6 cells
    Title: Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K63-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin thioesterase OTUB2
Names
OTU domain-containing ubiquitin aldehyde-binding protein 2
deubiquitinating enzyme OTUB2
otubain-2
ubiquitin-specific-processing protease OTUB2
NP_001171312.1
NP_080856.1
XP_006516248.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177841.2 → NP_001171312.1  ubiquitin thioesterase OTUB2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC154347, AC160131
    Consensus CDS
    CCDS49150.1
    UniProtKB/TrEMBL
    D3Z0Y8
    Related
    ENSMUSP00000098655.3, ENSMUST00000101094.9
    Conserved Domains (1) summary
    pfam10275
    Location:90 → 318
    Peptidase_C65; Peptidase C65 Otubain

  2. NM_026580.5 → NP_080856.1  ubiquitin thioesterase OTUB2 isoform 2

    See identical proteins and their annotated locations for NP_080856.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' region, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC154347, AC160131
    Consensus CDS
    CCDS36528.1
    UniProtKB/Swiss-Prot
    Q3TUZ2, Q9CQX0, Q9D4K8
    Related
    ENSMUSP00000021620.7, ENSMUST00000021620.13
    Conserved Domains (1) summary
    pfam10275
    Location:1 → 229
    Peptidase_C65; Peptidase C65 Otubain

RNA

  1. NR_033587.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and lacks 5' coding exons compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of any downstream ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC154347, AC160131

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    103343244..103372609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516185.5 → XP_006516248.3  ubiquitin thioesterase OTUB2 isoform X1

    Conserved Domains (1) summary
    pfam10275
    Location:65 → 292
    Peptidase_C65; Peptidase C65 Otubain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQX0.1 GenPept UniProtKB/Swiss-Prot:Q9CQX0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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