Etaa1 Ewing tumor-associated antigen 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Etaa1provided by MGI
Official Full Name: Ewing tumor-associated antigen 1provided by MGI
Primary source: MGI:MGI:1915395
See related: Ensembl:ENSMUSG00000016984 AllianceGenome:MGI:1915395
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5730466H23Rik
Summary: Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including positive regulation of protein serine/threonine kinase activity; regulation of DNA damage checkpoint; and replication fork processing. Predicted to act upstream of or within DNA repair. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nuclear replication fork. Orthologous to human ETAA1 (ETAA1 activator of ATR kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 5.4), liver E14 (RPKM 3.6) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A3.1; 11 10.44 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (17888753..17903875, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (17938753..17953875, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ETAA1 deficiency decreased clonal expansion cell autonomously within the responding T cells, causing no decrease in their division rate but increasing TP53-induced mRNAs and phosphorylation of H2AX, a marker of DNA replication stress induced by the ATM and ATR kinases.
Title: Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

RH124330 (e-PCR)
- UniSTS:161152

D11Mit78 (e-PCR), detects polymorphism
- UniSTS:126626

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in mitotic G2/M transition checkpoint	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA damage checkpoint	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA damage checkpoint	ISO Inferred from Sequence Orthology more info
involved_in replication fork processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in replication fork processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nuclear replication fork	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear replication fork	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ewing's tumor-associated antigen 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362970.1 → NP_001349899.1 ewing's tumor-associated antigen 1 homolog isoform 2

Status: VALIDATED

Source sequence(s)

AK034138, AL627070

Conserved Domains (1) summary

pfam15350
Location:1 → 712

ETAA1; Ewing's tumor-associated antigen 1 homolog
NM_026576.4 → NP_080852.2 ewing's tumor-associated antigen 1 homolog isoform 1

See identical proteins and their annotated locations for NP_080852.2

Status: VALIDATED

Source sequence(s)

AK018594, AK019965, AL627070

Consensus CDS

CCDS24452.1

UniProtKB/Swiss-Prot

Q5SVT3, Q8BZM6, Q8K332, Q9CS19, Q9D2Z9

Related

ENSMUSP00000075957.7, ENSMUST00000076661.7

Conserved Domains (1) summary

pfam15350
Location:79 → 865

ETAA1; Ewing's tumour-associated antigen 1 homologue