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Apool apolipoprotein O-like [ Mus musculus (house mouse) ]

Gene ID: 68117, updated on 11-Apr-2024

Summary

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Official Symbol
Apoolprovided by MGI
Official Full Name
apolipoprotein O-likeprovided by MGI
Primary source
MGI:MGI:1915367
See related
Ensembl:ENSMUSG00000025525 AllianceGenome:MGI:1915367
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Micos27; 6720473G16Rik; 9430083G14Rik; E130106L15Rik
Summary
Predicted to be involved in cristae formation. Located in mitochondrial inner membrane. Orthologous to human APOOL (apolipoprotein O like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 9.6), CNS E11.5 (RPKM 9.4) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X E1; X 48.76 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (111221049..111282452)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (112311352..112372755)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene testis expressed gene 16 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene Neighboring gene barrier to autointegration factor 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47777 Neighboring gene spermidine/spermine N1-acetyl transferase-like 1 Neighboring gene ubinuclein 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phenotypic annotation of the mouse X chromosome. Cox BJ, et al. Genome Res, 2010 Aug. PMID 20548051, Free PMC Article
  2. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
  3. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809
  4. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
  5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cristae formation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MICOS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MICOS complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
MICOS complex subunit Mic27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313733.1 → NP_001300662.1  MICOS complex subunit Mic27 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of the first exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AI132704, AK012398, DV061158
    UniProtKB/TrEMBL
    Q9CZB4
    Conserved Domains (1) summary
    pfam09769
    Location:37 → 174
    ApoO; Apolipoprotein O

  2. NM_001313734.1 → NP_001300663.1  MICOS complex subunit Mic27 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AI132704, AI587915, AK012398, DV061158
    Consensus CDS
    CCDS85799.1
    UniProtKB/TrEMBL
    B1AV14
    Related
    ENSMUSP00000109042.2, ENSMUST00000113415.2
    Conserved Domains (1) summary
    pfam09769
    Location:7 → 121
    ApoO; Apolipoprotein O

  3. NM_026565.3 → NP_080841.1  MICOS complex subunit Mic27 isoform 1 precursor

    See identical proteins and their annotated locations for NP_080841.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI132704, AK012398, DV061158
    Consensus CDS
    CCDS30359.1
    UniProtKB/Swiss-Prot
    Q78IK4
    UniProtKB/TrEMBL
    Q9CZB4
    Related
    ENSMUSP00000026599.4, ENSMUST00000026599.10
    Conserved Domains (1) summary
    pfam09769
    Location:42 → 179
    ApoO; Apolipoprotein O

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    111221049..111282452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q78IK4.1 GenPept UniProtKB/Swiss-Prot:Q78IK4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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