Gipc1 GIPC PDZ domain containing family, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gipc1provided by MGI
Official Full Name: GIPC PDZ domain containing family, member 1provided by MGI
Primary source: MGI:MGI:1926252
See related: Ensembl:ENSMUSG00000019433 AllianceGenome:MGI:1926252
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GIPC; TIP-2; TaxIP2; Semcap1; Glut1CIP; Rgs19ip1
Summary: Enables actin binding activity; identical protein binding activity; and myosin binding activity. Involved in several processes, including negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transforming growth factor beta receptor signaling pathway; and regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including cellular response to interleukin-7; endothelial cell migration; and glutamate secretion. Located in several cellular components, including Schaffer collateral - CA1 synapse; dendrite; and glutamatergic synapse. Is active in postsynapse and presynapse. Is expressed in several structures, including brain; future brain; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human GIPC1 (GIPC PDZ domain containing family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in stomach adult (RPKM 41.0), colon adult (RPKM 40.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C2; 8 40.22 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (84376037..84391418)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (83649408..83664789)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GIPC1 promotes tumor growth and migration in gastric cancer via activating PDGFR/PI3K/AKT signaling.
Title: GIPC1 promotes tumor growth and migration in gastric cancer via activating PDGFR/PI3K/AKT signaling.
Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport.
Title: Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport.
GIPC1 forms a domain-swapped dimer in an autoinhibited conformation that hinders binding of both PlexinD1 and myosin VI. PlexinD1 binding to GIPC1 releases the autoinhibition, promoting its interaction with myosin VI. GIPCs and myosin VI interact through two distinct interfaces and form an open-ended alternating array.
Title: Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex.
Down-regulation of endogenous GIPC1 is sufficient to inhibit the development of eye field cells from embryonic stem cells.
Title: The GIPC1-Akt1 Pathway Is Required for the Specification of the Eye Field in Mouse Embryonic Stem Cells.
Higher ratios of PSD-95/GluN2B and GAIP-interacting protein C-terminus (GIPC)/GluN2B were associated with poorer learning index scores across all ages.
Title: An increase in the association of GluN2B containing NMDA receptors with membrane scaffolding proteins was related to memory declines during aging.
findings identify Gipc1 as a new interactor for Vangl2; show that a myosin VI-Gipc1 protein complex can regulate Vangl2 traffic in heterologous cells; results indicate a broad role for Gipc1 in the development of both stereociliary bundles and cell polarization
Title: Gipc1 has a dual role in Vangl2 trafficking and hair bundle integrity in the inner ear.
TGFbetaR3 interaction with GIPC1 is critical for regulating invasion and growth factor responsiveness in epicardial cells, and dysregulation of epicardial cell proliferation and invasion contributes to failed coronary vessel development in Tgfbr3(-/-) mice
Title: The cytoplasmic domain of TGFβR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior.
GIPC1-MyoGEF complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion.
Title: GIPC1 interacts with MyoGEF and promotes MDA-MB-231 breast cancer cell invasion.
Fibroblast growth factor 2-induced Rac1 activation depends on the suppression of RhoG by a previously uncharacterized ternary S4-synectin-RhoGDI1 protein complex and activation via PKCalpha.
Title: Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway.
synectin deficiency results in increased degradation of PDGF-BB protein in arterial endothelial cell and, consequently, reduced recruitment of mural cells to newly forming arteries
Title: Synectin-dependent regulation of arterial maturation.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (2) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	TAS Traceable Author Statement more info	PubMed
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables myosin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cellular response to interleukin-7	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glutamate secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of melanin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein targeting	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein targeting	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of protein stability	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: PDZ domain-containing protein GIPC1

Names: GAIP C-terminus-interacting protein; RGS-GAIP interacting protein GIPC; RGS-GAIP-interacting protein; RGS19-interacting protein 1; SEMCAP-1; Tax interacting protein, clone 2; neurophilin1-IP; regulator of G-protein signaling 19 interacting protein 1; semaF cytoplasmic domain associated protein; semaF cytoplasmic domain-associated protein 1; synectin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018771.3 → NP_061241.1 PDZ domain-containing protein GIPC1

See identical proteins and their annotated locations for NP_061241.1

Status: VALIDATED

Source sequence(s)

BC003490

Consensus CDS

CCDS22457.1

UniProtKB/Swiss-Prot

Q9Z0G0

Related

ENSMUSP00000019577.9, ENSMUST00000019577.10

Conserved Domains (1) summary

cd00992
Location:132 → 210

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

84376037..84391418

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243739.2 → XP_030099599.1 PDZ domain-containing protein GIPC1 isoform X1

UniProtKB/Swiss-Prot

Q9Z0G0

Conserved Domains (1) summary

cd00992
Location:132 → 210

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...