Stx17 syntaxin 17 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stx17provided by MGI
Official Full Name: syntaxin 17provided by MGI
Primary source: MGI:MGI:1914977
See related: Ensembl:ENSMUSG00000061455 AllianceGenome:MGI:1914977
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4833418L03Rik; 6330411F21Rik; 9030425C21Rik
Summary: Predicted to enable SNAP receptor activity; SNARE binding activity; and enzyme binding activity. Predicted to be involved in several processes, including autophagosome membrane docking; endoplasmic reticulum to Golgi vesicle-mediated transport; and endoplasmic reticulum-Golgi intermediate compartment organization. Predicted to act upstream of or within protein localization to phagophore assembly site. Located in autophagosome. Is expressed in adrenal cortex. Orthologous to human STX17 (syntaxin 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 7.4), testis adult (RPKM 5.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B1; 4 26.07 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (48124912..48186507)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (48124906..48186507)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Key roles of autophagosome/endosome maturation mediated by Syntaxin17 in methamphetamine-induced neuronal damage in mice.
Title: Key roles of autophagosome/endosome maturation mediated by Syntaxin17 in methamphetamine-induced neuronal damage in mice.
Syntaxin17 contributes to obesity cardiomyopathy through promoting mitochondrial Ca[2+] overload in a Parkin-MCUb-dependent manner.
Title: Syntaxin17 contributes to obesity cardiomyopathy through promoting mitochondrial Ca(2+) overload in a Parkin-MCUb-dependent manner.
STING controls energy stress-induced autophagy and energy metabolism via STX17.
Title: STING controls energy stress-induced autophagy and energy metabolism via STX17.
Acinetobacter baumannii up-regulates LncRNA-GAS5 and promotes the degradation of STX17 by blocking the activation of YY1.
Title: Acinetobacter baumannii up-regulates LncRNA-GAS5 and promotes the degradation of STX17 by blocking the activation of YY1.
Syntaxin 17 inhibits ischemic neuronal injury by resuming autophagy flux and ameliorating endoplasmic reticulum stress.
Title: Syntaxin 17 inhibits ischemic neuronal injury by resuming autophagy flux and ameliorating endoplasmic reticulum stress.
L. pneumophila Lpg1137 can shut down ER-mitochondria communication through cleavage of syntaxin 17
Title: Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17.
Syntaxin-17 can be traced to the last eukaryotic common ancestor, hinting that the removal of damaged mitochondrial content may represent one of the earliest vesicle transport routes in the cell.
Title: Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system.
Study identifies syntaxin 17 (Stx17) as the autophagosomal SNARE required for fusion with the endosome/lysosome.
Title: The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	ISO Inferred from Sequence Orthology more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in autophagosome maturation	ISO Inferred from Sequence Orthology more info
involved_in autophagosome membrane docking	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum-Golgi intermediate compartment organization	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization to phagophore assembly site	ISO Inferred from Sequence Orthology more info
involved_in vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in COPII-coated ER to Golgi transport vesicle	ISO Inferred from Sequence Orthology more info
part_of HOPS complex	ISO Inferred from Sequence Orthology more info
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	ISO Inferred from Sequence Orthology more info
located_in autophagosome	IDA Inferred from Direct Assay more info	PubMed
located_in autophagosome	ISO Inferred from Sequence Orthology more info
is_active_in autophagosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in autophagosome membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondria-associated endoplasmic reticulum membrane contact site	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in smooth endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: syntaxin-17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026343.2 → NP_080619.2 syntaxin-17

See identical proteins and their annotated locations for NP_080619.2

Status: VALIDATED

Source sequence(s)

AK034718, AL683893, BB586682, BY766411

Consensus CDS

CCDS18164.1

UniProtKB/Swiss-Prot

B1AVI3, Q9D0I4, Q9D330

Related

ENSMUSP00000103348.3, ENSMUST00000107720.9

Conserved Domains (1) summary

cd15846
Location:161 → 222

SNARE_syntaxin17; SNARE motif of syntaxin 17

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

48124912..48186507

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538208.3 → XP_006538271.1 syntaxin-17 isoform X1

See identical proteins and their annotated locations for XP_006538271.1

UniProtKB/Swiss-Prot

B1AVI3, Q9D0I4, Q9D330

Conserved Domains (1) summary

cd15846
Location:161 → 222

SNARE_syntaxin17; SNARE motif of syntaxin 17
XM_036164376.1 → XP_036020269.1 syntaxin-17 isoform X2

Conserved Domains (1) summary

cd15846
Location:90 → 151

SNARE_syntaxin17; SNARE motif of syntaxin 17
XM_036164375.1 → XP_036020268.1 syntaxin-17 isoform X1

UniProtKB/Swiss-Prot

B1AVI3, Q9D0I4, Q9D330

Related

ENSMUSP00000068087.5, ENSMUST00000064765.6

Conserved Domains (1) summary

cd15846
Location:161 → 222

SNARE_syntaxin17; SNARE motif of syntaxin 17
XM_017320367.1 → XP_017175856.1 syntaxin-17 isoform X2

Conserved Domains (1) summary

cd15846
Location:90 → 151

SNARE_syntaxin17; SNARE motif of syntaxin 17