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Dusp6 dual specificity phosphatase 6 [ Mus musculus (house mouse) ]

Gene ID: 67603, updated on 21-Apr-2024

Summary

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Official Symbol
Dusp6provided by MGI
Official Full Name
dual specificity phosphatase 6provided by MGI
Primary source
MGI:MGI:1914853
See related
Ensembl:ENSMUSG00000019960 AllianceGenome:MGI:1914853
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MKP3; MKP-3; PYST1; 1300019I03Rik
Summary
Enables phosphoprotein phosphatase activity. Acts upstream of or within negative regulation of protein phosphorylation; protein dephosphorylation; and regulation of heart growth. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; renal cortex; and sensory organ. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Orthologous to human DUSP6 (dual specificity phosphatase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 46.1), adrenal adult (RPKM 45.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 D1; 10 51.13 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (99098676..99103351)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (99263231..99267489)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34574 Neighboring gene STARR-seq mESC enhancer starr_27709 Neighboring gene predicted gene, 34777 Neighboring gene STARR-seq mESC enhancer starr_27710 Neighboring gene STARR-positive B cell enhancer ABC_E5177 Neighboring gene predicted gene, 34921 Neighboring gene predicted gene, 48089 Neighboring gene STARR-seq mESC enhancer starr_27713 Neighboring gene uncharacterized LOC118567817 Neighboring gene STARR-seq mESC enhancer starr_27715 Neighboring gene STARR-seq mESC enhancer starr_27716 Neighboring gene STARR-positive B cell enhancer ABC_E2338 Neighboring gene STARR-seq mESC enhancer starr_27718

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DUSP6 Deficiency Attenuates Neurodegeneration after Global Cerebral Ischemia. Weng YC, et al. Int J Mol Sci, 2023 Apr 22. PMID 37175394, Free PMC Article
  2. LncTUG1 ameliorates renal tubular fibrosis in experimental diabetic nephropathy through the miR-145-5p/dual-specificity phosphatase 6 axis. Wang T, et al. Ren Fail, 2023 Dec. PMID 36794657, Free PMC Article
  3. Single-cell RNA sequencing uncovers the individual alteration of intestinal mucosal immunocytes in Dusp6 knockout mice. Chang CS, et al. iScience, 2022 Feb 18. PMID 35128351, Free PMC Article
  4. Identification of a gut microbiota member that ameliorates DSS-induced colitis in intestinal barrier enhanced Dusp6-deficient mice. Chang CS, et al. Cell Rep, 2021 Nov 23. PMID 34818535
  5. DUSP6 protects murine podocytes from high glucose‑induced inflammation and apoptosis. Chen L, et al. Mol Med Rep, 2020 Sep. PMID 32705203, Free PMC Article

See all (183) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Intestinal dual-specificity phosphatase 6 regulates the cold-induced gut microbiota remodeling to promote white adipose browning.
    Title: Intestinal dual-specificity phosphatase 6 regulates the cold-induced gut microbiota remodeling to promote white adipose browning.
  2. Dual-Specificity Phosphatase 6 Deficiency Attenuates Arterial-Injury-Induced Intimal Hyperplasia in Mice.
    Title: Dual-Specificity Phosphatase 6 Deficiency Attenuates Arterial-Injury-Induced Intimal Hyperplasia in Mice.
  3. Acute Endoplasmic Reticulum Stress Suppresses Hepatic Gluconeogenesis by Stimulating MAPK Phosphatase 3 Degradation.
    Title: Acute Endoplasmic Reticulum Stress Suppresses Hepatic Gluconeogenesis by Stimulating MAPK Phosphatase 3 Degradation.
  4. Ablation of Dual-Specificity Phosphatase 6 Protects against Nonalcoholic Fatty Liver Disease via Cytochrome P450 4A and Mitogen-Activated Protein Kinase.
    Title: Ablation of Dual-Specificity Phosphatase 6 Protects against Nonalcoholic Fatty Liver Disease via Cytochrome P450 4A and Mitogen-Activated Protein Kinase.
  5. Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis.
    Title: Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis.
  6. DUSP6 Deficiency Attenuates Neurodegeneration after Global Cerebral Ischemia.
    Title: DUSP6 Deficiency Attenuates Neurodegeneration after Global Cerebral Ischemia.
  7. LncTUG1 ameliorates renal tubular fibrosis in experimental diabetic nephropathy through the miR-145-5p/dual-specificity phosphatase 6 axis.
    Title: LncTUG1 ameliorates renal tubular fibrosis in experimental diabetic nephropathy through the miR-145-5p/dual-specificity phosphatase 6 axis.
  8. Dusp6 deficiency attenuates neutrophil-mediated cardiac damage in the acute inflammatory phase of myocardial infarction.
    Title: Dusp6 deficiency attenuates neutrophil-mediated cardiac damage in the acute inflammatory phase of myocardial infarction.
  9. Suppression of mutant Kirsten-RAS (KRAS(G12D))-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6.
    Title: Suppression of mutant Kirsten-RAS (KRAS(G12D))-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6.
  10. Short-Chain Fatty Acid Decreases the Expression of CEBPB to Inhibit miR-145-Mediated DUSP6 and Thus Further Suppresses Intestinal Inflammation.
    Title: Short-Chain Fatty Acid Decreases the Expression of CEBPB to Inhibit miR-145-Mediated DUSP6 and Thus Further Suppresses Intestinal Inflammation.
Submit: New GeneRIF Correction See all GeneRIFs (60)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC98540

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MAP kinase tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-tyrosine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-tyrosine dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of heart growth IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of heart growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dual specificity protein phosphatase 6
Names
MAP kinase phosphatase 3
mitogen-activated protein kinase phosphatase 3
NP_080544.1
XP_036011858.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026268.3 → NP_080544.1  dual specificity protein phosphatase 6

    See identical proteins and their annotated locations for NP_080544.1

    Status: VALIDATED

    Source sequence(s)
    AK159502, BQ176279, CJ278479
    Consensus CDS
    CCDS24147.1
    UniProtKB/Swiss-Prot
    Q542I5, Q9D7L4, Q9DBB1
    UniProtKB/TrEMBL
    Q3U786
    Related
    ENSMUSP00000020118.5, ENSMUST00000020118.5
    Conserved Domains (3) summary
    COG2453
    Location:204 → 356
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    cd00127
    Location:207 → 344
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:18 → 147
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    99098676..99103351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155965.1 → XP_036011858.1  dual specificity protein phosphatase 6 isoform X1

    UniProtKB/TrEMBL
    A0A1W2P715
    Related
    ENSMUSP00000151438.2, ENSMUST00000220291.2
    Conserved Domains (2) summary
    cd01446
    Location:18 → 134
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
    cl28904
    Location:134 → 197
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBB1.1 GenPept UniProtKB/Swiss-Prot:Q9DBB1

Gene LinkOut

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