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Patl2 protein associated with topoisomerase II homolog 2 (yeast) [ Mus musculus (house mouse) ]

Gene ID: 67578, updated on 21-Apr-2024

Summary

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Official Symbol
Patl2provided by MGI
Official Full Name
protein associated with topoisomerase II homolog 2 (yeast)provided by MGI
Primary source
MGI:MGI:1914828
See related
Ensembl:ENSMUSG00000027233 AllianceGenome:MGI:1914828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pat1a; 4930424G05Rik
Summary
Predicted to enable RNA binding activity and translation repressor activity. Acts upstream of or within negative regulation of cytoplasmic mRNA processing body assembly. Located in P-body and nucleus. Used to study ovarian disease. Orthologous to human PATL2 (PAT1 homolog 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 1.1), ovary adult (RPKM 0.7) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E5; 2 60.53 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121950589..122016670, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (122120108..122186189, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05545 Neighboring gene CTD small phosphatase like 2 Neighboring gene MAGE family member B3 Neighboring gene STARR-positive B cell enhancer ABC_E1597 Neighboring gene eukaryotic translation initiation factor 3, subunit J1 Neighboring gene SPG11, spatacsin vesicle trafficking associated Neighboring gene STARR-seq mESC enhancer starr_05546 Neighboring gene STARR-positive B cell enhancer ABC_E512 Neighboring gene STARR-seq mESC enhancer starr_05550 Neighboring gene beta-2 microglobulin Neighboring gene tripartite motif-containing 69 Neighboring gene telomere repeat binding bouquet formation protein 2 Neighboring gene ATP synthase F(0) complex subunit C1, mitochondrial pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PATL2 is a key actor of oocyte maturation whose invalidation causes infertility in women and mice. Christou-Kent M, et al. EMBO Mol Med, 2018 May. PMID 29661911, Free PMC Article
  2. PATL2 regulates mRNA homeostasis in oocytes by interacting with EIF4E and CPEB1. Zhang Z, et al. Development, 2023 Jun 15. PMID 37218508
  3. Distinct functions of maternal and somatic Pat1 protein paralogs. Marnef A, et al. RNA, 2010 Nov. PMID 20826699, Free PMC Article
  4. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PATL2 regulates mRNA homeostasis in oocytes by interacting with EIF4E and CPEB1.
    Title: PATL2 regulates mRNA homeostasis in oocytes by interacting with EIF4E and CPEB1.
  2. hPat1b localizes to P-bodies, while mPat1a-GFP is either found weakly in P-bodies or disperses P-bodies in a dominant-negative fashion.
    Title: Distinct functions of maternal and somatic Pat1 protein paralogs.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-quadruplex RNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(G) binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables poly(U) RNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables translation repressor activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in P-body assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of cytoplasmic mRNA processing body assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cytoplasmic mRNA processing body assembly ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in P-body ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein PAT1 homolog 2
Names
PAT1-like protein 2
protein PAT1 homolog a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026251.2 → NP_080527.2  protein PAT1 homolog 2

    See identical proteins and their annotated locations for NP_080527.2

    Status: VALIDATED

    Source sequence(s)
    AK010811, AL845457, BY714747, DV658440, DV660077
    Consensus CDS
    CCDS16653.1
    UniProtKB/Swiss-Prot
    A2ARM1, A6H5U9, Q9D5L4
    Related
    ENSMUSP00000028665.5, ENSMUST00000028665.5
    Conserved Domains (1) summary
    pfam09770
    Location:265 → 399
    PAT1; Topoisomerase II-associated protein PAT1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    121950589..122016670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319224.2 → XP_017174713.1  protein PAT1 homolog 2 isoform X1

    UniProtKB/Swiss-Prot
    A2ARM1, A6H5U9, Q9D5L4
    Conserved Domains (1) summary
    pfam09770
    Location:265 → 399
    PAT1; Topoisomerase II-associated protein PAT1

  2. XM_006500086.4 → XP_006500149.1  protein PAT1 homolog 2 isoform X2

    Conserved Domains (1) summary
    pfam09770
    Location:101 → 235
    PAT1; Topoisomerase II-associated protein PAT1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2ARM1.1 GenPept UniProtKB/Swiss-Prot:A2ARM1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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