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Klhl13 kelch-like 13 [ Mus musculus (house mouse) ]

Gene ID: 67455, updated on 5-Mar-2024

Summary

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Official Symbol
Klhl13provided by MGI
Official Full Name
kelch-like 13provided by MGI
Primary source
MGI:MGI:1914705
See related
Ensembl:ENSMUSG00000036782 AllianceGenome:MGI:1914705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bklhd2; 1200009K10Rik; D130072F20Rik
Summary
Predicted to enable cullin family protein binding activity and protein N-terminus binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination and regulation of cytokinesis. Predicted to act upstream of or within cell division. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in midbody. Is expressed in several structures, including brain; diaphragm; limb segment; skeletal musculature; and spinal cord mantle layer. Orthologous to human KLHL13 (kelch like family member 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 72.4), CNS E18 (RPKM 17.0) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X A2; X 17.22 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (23085510..23231340, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (23219271..23365161, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46917 Neighboring gene VISTA enhancer mm1395 Neighboring gene predicted gene, 54074 Neighboring gene predicted gene, 26131 Neighboring gene STARR-seq mESC enhancer starr_46918 Neighboring gene STARR-seq mESC enhancer starr_46919 Neighboring gene STARR-seq mESC enhancer starr_46920 Neighboring gene STARR-seq mESC enhancer starr_46924 Neighboring gene STARR-seq mESC enhancer starr_46925 Neighboring gene STARR-seq mESC enhancer starr_46926 Neighboring gene cyclin-dependent kinase 2 interacting protein pseudogene Neighboring gene WD repeat domain 44 Neighboring gene STARR-seq mESC enhancer starr_46927 Neighboring gene STARR-seq mESC enhancer starr_46928 Neighboring gene testis derived transcript pseudogene Neighboring gene testin LIM domain protein like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue. Duteil D, et al. Cell Rep, 2016 Oct 18. PMID 27760309, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kelch-like protein 13
Names
BTB and kelch domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290476.2 → NP_001277405.1  kelch-like protein 13 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start site, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AI451128, AK004677, AL773552
    Consensus CDS
    CCDS72348.1
    UniProtKB/TrEMBL
    Q497T4
    Related
    ENSMUSP00000110974.3, ENSMUST00000115319.9
    Conserved Domains (2) summary
    PHA03098
    Location:85 → 628
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:372 → 420
    Kelch; KELCH repeat [structural motif]

  2. NM_001310466.1 → NP_001297395.1  kelch-like protein 13 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start site, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AI451128, AK004677, AL773552
    Consensus CDS
    CCDS81105.1
    UniProtKB/TrEMBL
    Q497T4
    Related
    ENSMUSP00000110971.3, ENSMUST00000115316.9
    Conserved Domains (2) summary
    PHA03098
    Location:77 → 620
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:364 → 412
    Kelch; KELCH repeat [structural motif]

  3. NM_001381891.1 → NP_001368820.1  kelch-like protein 13 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL773552, AL808116
    UniProtKB/TrEMBL
    Q497T4
    Conserved Domains (3) summary
    PHA03098
    Location:97 → 640
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:384 → 432
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:74 → 201
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

  4. NM_001381892.1 → NP_001368821.1  kelch-like protein 13 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL773552, AL808116
    UniProtKB/TrEMBL
    Q497T4
    Conserved Domains (3) summary
    PHA03098
    Location:97 → 640
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:384 → 432
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:74 → 201
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

  5. NM_001381893.1 → NP_001368822.1  kelch-like protein 13 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL773552
    UniProtKB/Swiss-Prot
    A2AL86, A2AL87, A2AL88, A2AL89, Q80TF4, Q9DBY7
    UniProtKB/TrEMBL
    Q497T4
    Conserved Domains (3) summary
    PHA03098
    Location:91 → 634
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:378 → 426
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:68 → 195
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

  6. NM_001381894.1 → NP_001368823.1  kelch-like protein 13 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL773552
    UniProtKB/Swiss-Prot
    A2AL86, A2AL87, A2AL88, A2AL89, Q80TF4, Q9DBY7
    UniProtKB/TrEMBL
    Q497T4
    Related
    ENSMUSP00000110972.3, ENSMUST00000115317.9
    Conserved Domains (3) summary
    PHA03098
    Location:91 → 634
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:378 → 426
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:68 → 195
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

  7. NM_001381895.1 → NP_001368824.1  kelch-like protein 13 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL773552, AL808116
    UniProtKB/TrEMBL
    Q497T4
    Conserved Domains (3) summary
    PHA03098
    Location:75 → 618
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:362 → 410
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:52 → 179
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

  8. NM_001381896.1 → NP_001368825.1  kelch-like protein 13 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL773552, AL808116
    UniProtKB/TrEMBL
    Q497T4
    Related
    ENSMUSP00000041190.5, ENSMUST00000035973.5
    Conserved Domains (3) summary
    PHA03098
    Location:75 → 618
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:362 → 410
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:52 → 179
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

  9. NM_026167.4 → NP_080443.1  kelch-like protein 13 isoform 1

    See identical proteins and their annotated locations for NP_080443.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shortest isoform (1).
    Source sequence(s)
    AI451128, AK004677, BY136647
    Consensus CDS
    CCDS40891.1
    UniProtKB/TrEMBL
    Q497T4
    Conserved Domains (3) summary
    PHA03098
    Location:75 → 618
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:362 → 410
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:52 → 179
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    23085510..23231340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251489.2 → XP_030107349.1  kelch-like protein 13 isoform X1

    UniProtKB/TrEMBL
    Q497T4
    Conserved Domains (3) summary
    PHA03098
    Location:97 → 640
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:384 → 432
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:74 → 201
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

  2. XM_011247487.3 → XP_011245789.1  kelch-like protein 13 isoform X1

    See identical proteins and their annotated locations for XP_011245789.1

    UniProtKB/TrEMBL
    Q497T4
    Conserved Domains (3) summary
    PHA03098
    Location:97 → 640
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:384 → 432
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:74 → 201
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

  3. XM_011247492.4 → XP_011245794.1  kelch-like protein 13 isoform X4

    See identical proteins and their annotated locations for XP_011245794.1

    UniProtKB/TrEMBL
    Q497T4
    Conserved Domains (3) summary
    PHA03098
    Location:75 → 618
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:362 → 410
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:52 → 179
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

  4. XM_036162081.1 → XP_036017974.1  kelch-like protein 13 isoform X4

    UniProtKB/TrEMBL
    Q497T4
    Conserved Domains (3) summary
    PHA03098
    Location:75 → 618
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:362 → 410
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:52 → 179
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

  5. XM_036162080.1 → XP_036017973.1  kelch-like protein 13 isoform X4

    UniProtKB/TrEMBL
    Q497T4
    Conserved Domains (3) summary
    PHA03098
    Location:75 → 618
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:362 → 410
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:52 → 179
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

  6. XM_011247488.4 → XP_011245790.1  kelch-like protein 13 isoform X2

    UniProtKB/TrEMBL
    Q497T4
    Conserved Domains (3) summary
    PHA03098
    Location:94 → 637
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:381 → 429
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:71 → 198
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

  7. XM_036162082.1 → XP_036017975.1  kelch-like protein 13 isoform X5

    UniProtKB/TrEMBL
    Q497T4
    Related
    ENSMUSP00000110968.2, ENSMUST00000115313.8
    Conserved Domains (3) summary
    PHA03098
    Location:41 → 584
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:328 → 376
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:18 → 145
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

  8. XM_030251491.2 → XP_030107351.1  kelch-like protein 13 isoform X3

    UniProtKB/Swiss-Prot
    A2AL86, A2AL87, A2AL88, A2AL89, Q80TF4, Q9DBY7
    UniProtKB/TrEMBL
    Q497T4
    Conserved Domains (3) summary
    PHA03098
    Location:91 → 634
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:378 → 426
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:68 → 195
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80TF4.3 GenPept UniProtKB/Swiss-Prot:Q80TF4

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