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Ankrd33b ankyrin repeat domain 33B [ Mus musculus (house mouse) ]

Gene ID: 67434, updated on 5-Mar-2024

Summary

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Official Symbol
Ankrd33bprovided by MGI
Official Full Name
ankyrin repeat domain 33Bprovided by MGI
Primary source
MGI:MGI:1917904
See related
Ensembl:ENSMUSG00000022237 AllianceGenome:MGI:1917904
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610012A05Rik; 3021401C12Rik; 5730557B15Rik
Summary
Predicted to enable DNA binding activity. Is expressed in brain; embryo endoderm; notochord; and retina. Orthologous to human ANKRD33B (ankyrin repeat domain 33B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 10.0), cortex adult (RPKM 6.8) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 B2; 15 12.76 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (31278328..31370446, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (31291479..31367802, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene death-associated protein Neighboring gene predicted gene, 41285 Neighboring gene STARR-positive B cell enhancer ABC_E3134 Neighboring gene family with sequence similarity 136, member B, pseudogene Neighboring gene STARR-seq mESC enhancer starr_38282 Neighboring gene STARR-positive B cell enhancer ABC_E9415 Neighboring gene STARR-positive B cell enhancer ABC_E5472 Neighboring gene STARR-seq mESC enhancer starr_38287 Neighboring gene predicted gene, 41286 Neighboring gene STARR-seq mESC enhancer starr_38289 Neighboring gene ropporin 1-like Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl. Yoshida S, et al. Hum Mol Genet, 2004 Jul 15. PMID 15163632
  2. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
  3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 33B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164441.1 → NP_001157913.1  ankyrin repeat domain-containing protein 33B isoform 3

    See identical proteins and their annotated locations for NP_001157913.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC115735, AC123917
    Consensus CDS
    CCDS49589.1
    UniProtKB/Swiss-Prot
    Q3U0L2, Q8BJA8, Q9CYB2, Q9CZ88, Q9DCQ8
    Related
    ENSMUSP00000118984.2, ENSMUST00000123325.9
    Conserved Domains (4) summary
    cd00204
    Location:112 → 239
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:121 → 216
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:83 → 136
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:116 → 148
    ANK; ANK repeat [structural motif]

  2. NM_001357922.1 → NP_001344851.1  ankyrin repeat domain-containing protein 33B isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 4 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC115735, AC123917
    Conserved Domains (1) summary
    cd00204
    Location:1 → 49
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

  3. NM_001357923.1 → NP_001344852.1  ankyrin repeat domain-containing protein 33B isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 5, which is shorter than isoform 1.
    Source sequence(s)
    AC115735, AC123917
    Conserved Domains (2) summary
    cd00204
    Location:24 → 101
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:47 → 78
    ANK; ANK repeat [structural motif]

  4. NM_026153.3 → NP_080429.1  ankyrin repeat domain-containing protein 33B isoform 1

    See identical proteins and their annotated locations for NP_080429.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate splice pattern in the 3' coding region and 3' UTR, compared to variant 3. The resulting isoform (1) has a shorter and distinct C-terminus, compared to isoform 3.
    Source sequence(s)
    AC123917, AK012871, BC100327
    Consensus CDS
    CCDS27409.1
    UniProtKB/TrEMBL
    H7BX04
    Related
    ENSMUSP00000076209.5, ENSMUST00000076942.5

  5. NM_027496.3 → NP_081772.1  ankyrin repeat domain-containing protein 33B isoform 2

    See identical proteins and their annotated locations for NP_081772.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 3. The resulting isoform (2) lacks an internal segment near the N-terminus, compared to isoform 3.
    Source sequence(s)
    AC123917, AK017844, BC100327
    Consensus CDS
    CCDS27408.1
    UniProtKB/Swiss-Prot
    Q3U0L2
    Related
    ENSMUSP00000106040.3, ENSMUST00000110410.10
    Conserved Domains (3) summary
    cd00204
    Location:109 → 230
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:112 → 207
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:107 → 139
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    31278328..31370446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159549.1 → XP_036015442.1  ankyrin repeat domain-containing protein 33B isoform X1

    Conserved Domains (3) summary
    sd00045
    Location:85 → 114
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:84 → 136
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:121 → 209
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_006520155.5 → XP_006520218.1  ankyrin repeat domain-containing protein 33B isoform X2

    Conserved Domains (2) summary
    sd00045
    Location:85 → 114
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:85 → 160
    Ank_2; Ankyrin repeats (3 copies)

RNA

  1. XR_004938864.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U0L2.1 GenPept UniProtKB/Swiss-Prot:Q3U0L2

Gene LinkOut

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