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Mboat2 membrane bound O-acyltransferase domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 67216, updated on 11-Apr-2024

Summary

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Official Symbol
Mboat2provided by MGI
Official Full Name
membrane bound O-acyltransferase domain containing 2provided by MGI
Primary source
MGI:MGI:1914466
See related
Ensembl:ENSMUSG00000020646 AllianceGenome:MGI:1914466
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oact2; LPCAT4; Moact2; 2810049G06Rik
Summary
Enables 1-acylglycerophosphocholine O-acyltransferase activity and 1-acylglycerophosphoethanolamine O-acyltransferase activity. Involved in phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; and regulation of chondrocyte differentiation. Located in endoplasmic reticulum membrane. Is expressed in several structures, including T1 rib costal cartilage; alimentary system; genitourinary system; nervous system; and respiratory system. Orthologous to human MBOAT2 (membrane bound O-acyltransferase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 6.5), frontal lobe adult (RPKM 5.2) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Mboat2 in Genome Data Viewer
Location:
12 A1.3; 12 8.5 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (24881401..25014399)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (24831435..24964400)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900060N12 gene Neighboring gene STARR-seq mESC enhancer starr_31760 Neighboring gene predicted gene, 26211 Neighboring gene STARR-positive B cell enhancer ABC_E5324 Neighboring gene kinase D-interacting substrate 220 Neighboring gene predicted gene, 36236 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:25695412-25695595 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:25777982-25778091 Neighboring gene STARR-positive B cell enhancer mm9_chr12:25780927-25781228 Neighboring gene inhibitor of DNA binding 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lysophosphatidylcholine acyltransferase 4 is involved in chondrogenic differentiation of ATDC5 cells. Tabe S, et al. Sci Rep, 2017 Dec 1. PMID 29196633, Free PMC Article
  2. Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. Hishikawa D, et al. Proc Natl Acad Sci U S A, 2008 Feb 26. PMID 18287005, Free PMC Article
  3. LPT1 encodes a membrane-bound O-acyltransferase involved in the acylation of lysophospholipids in the yeast Saccharomyces cerevisiae. Tamaki H, et al. J Biol Chem, 2007 Nov 23. PMID 17890783
  4. A complex oscillating network of signaling genes underlies the mouse segmentation clock. Dequéant ML, et al. Science, 2006 Dec 8. PMID 17095659
  5. A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. Nakano Y, et al. PLoS Genet, 2012. PMID 23055939, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-acylglycerophosphocholine O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-acylglycerophosphocholine O-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 1-acylglycerophosphocholine O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables 1-acylglycerophosphoserine O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylcholine acyl-chain remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylcholine acyl-chain remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylethanolamine acyl-chain remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylethanolamine acyl-chain remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylserine acyl-chain remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lysophospholipid acyltransferase 2
Names
1-acylglycerophosphocholine O-acyltransferase
1-acylglycerophosphoethanolamine O-acyltransferase
LPC acyltransferase 4
LPCAT
LPEAT
LPLAT 2
O-acyltransferase (membrane bound) domain containing 2
O-acyltransferase domain-containing protein 2
lyso-PC acyltransferase 4
lyso-PE acyltransferase
lysophosphatidylcholine acyltransferase 4
lysophosphatidylethanolamine acyltransferase
mLPCAT4
membrane-bound O-acyltransferase domain-containing protein 2
NP_001076810.1
NP_080313.2
XP_006515230.1
XP_006515231.1
XP_006515233.1
XP_006515235.1
XP_011242191.1
XP_011242192.1
XP_017170653.1
XP_030102743.1
XP_030102744.1
XP_030102745.1
XP_030102746.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083341.1 → NP_001076810.1  lysophospholipid acyltransferase 2 isoform b

    See identical proteins and their annotated locations for NP_001076810.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), that is missing an internal segment compared to isoform a.
    Source sequence(s)
    AC159307, AK003295, AK031824, AU067514
    Consensus CDS
    CCDS36423.1
    UniProtKB/Swiss-Prot
    Q8R3I2
    UniProtKB/TrEMBL
    Q8BN01
    Related
    ENSMUSP00000152348.2, ENSMUST00000221952.2
    Conserved Domains (1) summary
    cl00738
    Location:13 → 444
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

  2. NM_026037.3 → NP_080313.2  lysophospholipid acyltransferase 2 isoform a

    See identical proteins and their annotated locations for NP_080313.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (a).
    Source sequence(s)
    AC159307, AK003295, AK031824, AK034873, AU067514
    Consensus CDS
    CCDS25845.1
    UniProtKB/Swiss-Prot
    A9EDS7, Q8BHH5, Q8BM56, Q8R192, Q8R3I2, Q9CZ73
    Related
    ENSMUSP00000106567.4, ENSMUST00000110942.11
    Conserved Domains (1) summary
    cl00738
    Location:13 → 476
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    24881401..25014399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515172.5 → XP_006515235.1  lysophospholipid acyltransferase 2 isoform X4

    See identical proteins and their annotated locations for XP_006515235.1

    UniProtKB/TrEMBL
    A0A217FL69
    Conserved Domains (1) summary
    cl00738
    Location:2 → 325
    MBOAT; membrane-bound O-acyltransferase family

  2. XM_030246884.2 → XP_030102744.1  lysophospholipid acyltransferase 2 isoform X3

    UniProtKB/TrEMBL
    A0A217FL69
    Conserved Domains (1) summary
    cl00738
    Location:8 → 335
    MBOAT; membrane-bound O-acyltransferase family

  3. XM_006515167.5 → XP_006515230.1  lysophospholipid acyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006515230.1

    UniProtKB/TrEMBL
    A0A217FL69
    Conserved Domains (1) summary
    cl00738
    Location:1 → 387
    MBOAT; membrane-bound O-acyltransferase family

  4. XM_006515168.2 → XP_006515231.1  lysophospholipid acyltransferase 2 isoform X2

    UniProtKB/TrEMBL
    A0A217FL69
    Related
    ENSMUSP00000077937.8, ENSMUST00000078902.8
    Conserved Domains (1) summary
    cl00738
    Location:13 → 355
    MBOAT; membrane-bound O-acyltransferase family

  5. XM_011243889.3 → XP_011242191.1  lysophospholipid acyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_011242191.1

    UniProtKB/TrEMBL
    A0A217FL69
    Conserved Domains (1) summary
    cl00738
    Location:1 → 387
    MBOAT; membrane-bound O-acyltransferase family

  6. XM_030246883.2 → XP_030102743.1  lysophospholipid acyltransferase 2 isoform X2

    UniProtKB/TrEMBL
    A0A217FL69
    Conserved Domains (1) summary
    cl00738
    Location:13 → 355
    MBOAT; membrane-bound O-acyltransferase family

  7. XM_030246886.2 → XP_030102746.1  lysophospholipid acyltransferase 2 isoform X4

    UniProtKB/TrEMBL
    A0A217FL69
    Conserved Domains (1) summary
    cl00738
    Location:2 → 325
    MBOAT; membrane-bound O-acyltransferase family

  8. XM_006515170.5 → XP_006515233.1  lysophospholipid acyltransferase 2 isoform X3

    See identical proteins and their annotated locations for XP_006515233.1

    UniProtKB/TrEMBL
    A0A217FL69
    Conserved Domains (1) summary
    cl00738
    Location:8 → 335
    MBOAT; membrane-bound O-acyltransferase family

  9. XM_017315164.3 → XP_017170653.1  lysophospholipid acyltransferase 2 isoform X4

    UniProtKB/TrEMBL
    A0A217FL69
    Conserved Domains (1) summary
    cl00738
    Location:2 → 325
    MBOAT; membrane-bound O-acyltransferase family

  10. XM_030246885.2 → XP_030102745.1  lysophospholipid acyltransferase 2 isoform X4

    UniProtKB/TrEMBL
    A0A217FL69
    Conserved Domains (1) summary
    cl00738
    Location:2 → 325
    MBOAT; membrane-bound O-acyltransferase family

  11. XM_011243890.3 → XP_011242192.1  lysophospholipid acyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_011242192.1

    UniProtKB/TrEMBL
    A0A217FL69
    Conserved Domains (1) summary
    cl00738
    Location:1 → 387
    MBOAT; membrane-bound O-acyltransferase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R3I2.1 GenPept UniProtKB/Swiss-Prot:Q8R3I2

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