Bpifa5 BPI fold containing family A, member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bpifa5provided by MGI
Official Full Name: BPI fold containing family A, member 5provided by MGI
Primary source: MGI:MGI:1914385
See related: Ensembl:ENSMUSG00000027484 AllianceGenome:MGI:1914385
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tpl; Pluncl; Splunc5; 2310021H06Rik; 2310074B19Rik
Summary: Predicted to enable lipid binding activity. Predicted to be involved in several processes, including antimicrobial humoral response; immune response in nasopharyngeal-associated lymphoid tissue; and negative regulation of single-species biofilm formation in or on host organism. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human BPIFA1 (BPI fold containing family A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 2 H1; 2 76.19 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (154004527..154010366)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (154162607..154168446)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

splunc5, splunc1, and lplunc1 are expressed in unique domains along a continuous corridor of oral, lingual, pharyngeal, and respiratory epithelia [splunc5]
Title: Cloning and expression of a mouse member of the PLUNC protein family exclusively expressed in tongue epithelium.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antibacterial humoral response	ISO Inferred from Sequence Orthology more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response in nasopharyngeal-associated lymphoid tissue	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal-level water homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of single-species biofilm formation in or on host organism	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of single-species biofilm formation in or on host organism	ISO Inferred from Sequence Orthology more info
involved_in regulation of sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in surfactant homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in surfactant homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: BPI fold-containing family A member 5

Names: BPI fold-containing family A member Pluncl; palate lung and nasal carcinoma-like protein; short palate lung and nasal clone protein 5; tongue plunc-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.