Atp5f1e ATP synthase F1 subunit epsilon [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp5f1eprovided by MGI
Official Full Name: ATP synthase F1 subunit epsilonprovided by MGI
Primary source: MGI:MGI:1855697
See related: Ensembl:ENSMUSG00000016252 AllianceGenome:MGI:1855697
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ATPE; Atp5e; 2410043G19Rik
Summary: Predicted to enable P-type proton-exporting transporter activity. Predicted to contribute to ATP hydrolysis activity and proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in mitochondrial ATP synthesis coupled proton transport. Predicted to act upstream of or within ATP synthesis coupled proton transport. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 3. Orthologous to several human genes including ATP5F1E (ATP synthase F1 subunit epsilon). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in heart adult (RPKM 220.7), kidney adult (RPKM 213.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 97.95 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (174302868..174305894, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (174461075..174464101, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AV000645 (e-PCR)
- UniSTS:178789

RH125638 (e-PCR)
- UniSTS:162428

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables P-type proton-exporting transporter activity	ISA Inferred from Sequence Alignment more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ATP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proton motive force-driven ATP synthesis	ISA Inferred from Sequence Alignment more info	PubMed
involved_in proton motive force-driven mitochondrial ATP synthesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	HDA more info	PubMed
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
part_of mitochondrial proton-transporting ATP synthase complex	ISA Inferred from Sequence Alignment more info	PubMed
part_of mitochondrial proton-transporting ATP synthase complex	ISO Inferred from Sequence Orthology more info
part_of mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
part_of proton-transporting ATP synthase complex, catalytic core F(1)	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP synthase subunit epsilon, mitochondrial

Names: ATP synthase epsilon chain, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit; ATPase subunit epsilon; mitochondrial ATP synthase epsilon subunit

NP_080259.1

EC 7.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.