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Cuedc2 CUE domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 67116, updated on 5-Mar-2024

Summary

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Official Symbol
Cuedc2provided by MGI
Official Full Name
CUE domain containing 2provided by MGI
Primary source
MGI:MGI:1914366
See related
Ensembl:ENSMUSG00000036748 AllianceGenome:MGI:1914366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3010002G01Rik
Summary
Predicted to enable ubiquitin binding activity. Acts upstream of or within negative regulation of cytokine production involved in inflammatory response and negative regulation of macrophage cytokine production. Predicted to be located in cytosol; nuclear membrane; and nucleoplasm. Is expressed in cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human CUEDC2 (CUE domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 37.4), CNS E14 (RPKM 32.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C3; 19 38.81 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46318251..46327144, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46329812..46338672, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 Neighboring gene RIKEN cDNA 4833438C02 gene Neighboring gene STARR-positive B cell enhancer ABC_E9457 Neighboring gene pleckstrin and Sec7 domain containing Neighboring gene F-box and leucine-rich repeat protein 15 Neighboring gene STARR-positive B cell enhancer ABC_E973 Neighboring gene predicted gene, 36493 Neighboring gene microRNA 146b Neighboring gene RIKEN cDNA 2310034G01 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CUEDC2 controls osteoblast differentiation and bone formation via SOCS3-STAT3 pathway. Kim JW, et al. Cell Death Dis, 2020 May 11. PMID 32393737, Free PMC Article
  2. CUEDC2 modulates cardiomyocyte oxidative capacity by regulating GPX1 stability. Jian Z, et al. EMBO Mol Med, 2016 Jul. PMID 27286733, Free PMC Article
  3. CUEDC2 Protects Against Experimental Colitis and Suppresses Excessive Proliferation of Intestinal Mucosa. Wang S, et al. Dig Dis Sci, 2015 Dec. PMID 26182901
  4. Dysregulation of the miR-324-5p-CUEDC2 axis leads to macrophage dysfunction and is associated with colon cancer. Chen Y, et al. Cell Rep, 2014 Jun 26. PMID 24882011
  5. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long Noncoding RNA AROD Inhibits Host Antiviral Innate Immunity via the miR-324-5p-CUEDC2 Axis.
    Title: Long Noncoding RNA AROD Inhibits Host Antiviral Innate Immunity via the miR-324-5p-CUEDC2 Axis.
  2. CUEDC2 controls osteoblast differentiation and bone formation via SOCS3-STAT3 pathway.
    Title: CUEDC2 controls osteoblast differentiation and bone formation via SOCS3-STAT3 pathway.
  3. Notably, CUEDC2 promoted E3 ubiquitin ligases tripartite motif-containing 33 (TRIM33)-mediated the antioxidant enzyme, glutathione peroxidase 1 (GPX1) ubiquitination, and proteasome-dependent degradation.
    Title: CUEDC2 modulates cardiomyocyte oxidative capacity by regulating GPX1 stability.
  4. These findings demonstrate that CUEDC2 plays an important role in protection from colonic inflammation, primarily by inhibiting the NF-kappaB and STAT3 signaling pathways and preventing excessive proliferation of the inflammatory epithelial cell.
    Title: CUEDC2 Protects Against Experimental Colitis and Suppresses Excessive Proliferation of Intestinal Mucosa.
  5. CUEDC2 plays a crucial role in modulating macrophage function and is associated with both colitis and colon tumorigenesis.
    Title: Dysregulation of the miR-324-5p-CUEDC2 axis leads to macrophage dysfunction and is associated with colon cancer.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of macrophage cytokine production ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CUE domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164290.1 → NP_001157762.1  CUE domain-containing protein 2 isoform a

    See identical proteins and their annotated locations for NP_001157762.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, 3 and 4 encode the same isoform (a).
    Source sequence(s)
    AC114539, AK008842, AK013884, BY279028, CX207621, CX218143, CX223880
    Consensus CDS
    CCDS29876.1
    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Related
    ENSMUSP00000129589.2, ENSMUST00000167861.8
    Conserved Domains (1) summary
    cd14367
    Location:144 → 183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  2. NM_001164291.1 → NP_001157763.1  CUE domain-containing protein 2 isoform a

    See identical proteins and their annotated locations for NP_001157763.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (a).
    Source sequence(s)
    AC114539, AK008842, AK013884, BY279028, CX207621
    Consensus CDS
    CCDS29876.1
    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Related
    ENSMUSP00000053469.9, ENSMUST00000051234.9
    Conserved Domains (1) summary
    cd14367
    Location:144 → 183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  3. NM_001164292.1 → NP_001157764.1  CUE domain-containing protein 2 isoform a

    See identical proteins and their annotated locations for NP_001157764.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (a).
    Source sequence(s)
    AC114539, AK008842, AK013884, BY279028
    Consensus CDS
    CCDS29876.1
    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Related
    ENSMUSP00000158425.2, ENSMUST00000235485.2
    Conserved Domains (1) summary
    cd14367
    Location:144 → 183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  4. NM_001164293.1 → NP_001157765.1  CUE domain-containing protein 2 isoform b

    See identical proteins and their annotated locations for NP_001157765.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform b) is shorter than isoform a.
    Source sequence(s)
    AC114539, AK008842, AK013884, BY279028, BY312150
    Consensus CDS
    CCDS89410.1
    UniProtKB/TrEMBL
    A0A494BAT2, Q9CVB0
    Related
    ENSMUSP00000158178.2, ENSMUST00000235977.2
    Conserved Domains (1) summary
    cd14367
    Location:133 → 172
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  5. NM_001164294.1 → NP_001157766.1  CUE domain-containing protein 2 isoform c

    See identical proteins and their annotated locations for NP_001157766.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform c) is shorter than isoform a. Variants 6 and 7 encode the same isoform (c).
    Source sequence(s)
    AC114539, AK008842, AK013884, BY279028, CK625575
    Consensus CDS
    CCDS89409.1
    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:126 → 165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  6. NM_001164295.1 → NP_001157767.1  CUE domain-containing protein 2 isoform c

    See identical proteins and their annotated locations for NP_001157767.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform c) is shorter than isoform a. Variants 6 and 7 encode the same isoform (c).
    Source sequence(s)
    AC114539, AK008842, AK013884, BY279028
    Consensus CDS
    CCDS89409.1
    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Related
    ENSMUSP00000158362.2, ENSMUST00000236980.2
    Conserved Domains (1) summary
    cd14367
    Location:126 → 165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  7. NM_024192.2 → NP_077154.2  CUE domain-containing protein 2 isoform a

    See identical proteins and their annotated locations for NP_077154.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (a).
    Source sequence(s)
    AC114539, AK008842, AK013884, BY279028, CX207621, CX223880
    Consensus CDS
    CCDS29876.1
    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Related
    ENSMUSP00000157840.2, ENSMUST00000236061.2
    Conserved Domains (1) summary
    cd14367
    Location:144 → 183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    46318251..46327144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251035.2 → XP_030106895.1  CUE domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A494BAT2, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:133 → 172
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  2. XM_006527276.4 → XP_006527339.1  CUE domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006527339.1

    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:144 → 183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  3. XM_030251041.2 → XP_030106901.1  CUE domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:126 → 165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  4. XM_030251036.2 → XP_030106896.1  CUE domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A494BAT2, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:133 → 172
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  5. XM_011247321.3 → XP_011245623.1  CUE domain-containing protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011245623.1

    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:126 → 165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  6. XM_011247320.3 → XP_011245622.1  CUE domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011245622.1

    UniProtKB/TrEMBL
    A0A494BAT2, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:133 → 172
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  7. XM_030251043.2 → XP_030106903.1  CUE domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:126 → 165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  8. XM_036161662.1 → XP_036017555.1  CUE domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A494BAT2, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:133 → 172
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  9. XM_030251033.2 → XP_030106893.1  CUE domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:144 → 183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  10. XM_030251040.2 → XP_030106900.1  CUE domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:126 → 165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  11. XM_006527280.3 → XP_006527343.1  CUE domain-containing protein 2 isoform X3

    See identical proteins and their annotated locations for XP_006527343.1

    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:126 → 165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  12. XM_006527278.4 → XP_006527341.1  CUE domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006527341.1

    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:144 → 183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  13. XM_030251039.2 → XP_030106899.1  CUE domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:126 → 165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  14. XM_011247318.3 → XP_011245620.1  CUE domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011245620.1

    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Related
    ENSMUSP00000157580.2, ENSMUST00000236046.2
    Conserved Domains (1) summary
    cd14367
    Location:144 → 183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  15. XM_030251037.2 → XP_030106897.1  CUE domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A494BAT2, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:133 → 172
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  16. XM_006527277.5 → XP_006527340.1  CUE domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006527340.1

    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:144 → 183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  17. XM_006527279.5 → XP_006527342.1  CUE domain-containing protein 2 isoform X3

    See identical proteins and their annotated locations for XP_006527342.1

    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:126 → 165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  18. XM_030251034.2 → XP_030106894.1  CUE domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A494BAT2, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:133 → 172
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  19. XM_006527275.5 → XP_006527338.1  CUE domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006527338.1

    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:144 → 183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  20. XM_030251042.2 → XP_030106902.1  CUE domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:126 → 165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  21. XM_011247319.3 → XP_011245621.1  CUE domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011245621.1

    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:144 → 183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  22. XM_030251038.2 → XP_030106898.1  CUE domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:126 → 165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  23. XM_036161660.1 → XP_036017553.1  CUE domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A494BAT2, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:133 → 172
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  24. XM_030251044.1 → XP_030106904.1  CUE domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A494BB93, Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:126 → 165
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins

  25. XM_011247317.3 → XP_011245619.1  CUE domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011245619.1

    UniProtKB/Swiss-Prot
    Q99LC1, Q9CXX9
    UniProtKB/TrEMBL
    Q9CVB0
    Conserved Domains (1) summary
    cd14367
    Location:144 → 183
    CUE_CUED2; CUE domain found in CUE domain-containing protein 2 (CUED2) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CXX9.1 GenPept UniProtKB/Swiss-Prot:Q9CXX9

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