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Mon2 MON2 homolog, regulator of endosome to Golgi trafficking [ Mus musculus (house mouse) ]

Gene ID: 67074, updated on 5-Mar-2024

Summary

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Official Symbol
Mon2provided by MGI
Official Full Name
MON2 homolog, regulator of endosome to Golgi traffickingprovided by MGI
Primary source
MGI:MGI:1914324
See related
Ensembl:ENSMUSG00000034602 AllianceGenome:MGI:1914324
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sf21; mKIAA1040; 2610528O22Rik
Summary
Predicted to act upstream of or within protein transport. Predicted to be located in early endosome membrane. Orthologous to human MON2 (MON2 homolog, regulator of endosome-to-Golgi trafficking). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 7.0), genital fat pad adult (RPKM 6.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 D2; 10 72.15 cM
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (122827965..122913684, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (122992060..123076505, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1H (PP2C domain containing) Neighboring gene STARR-seq mESC enhancer starr_28140 Neighboring gene predicted gene, 51818 Neighboring gene STARR-positive B cell enhancer ABC_E8375 Neighboring gene STARR-positive B cell enhancer ABC_E5196 Neighboring gene STARR-positive B cell enhancer ABC_E9356 Neighboring gene STARR-positive B cell enhancer ABC_E10651 Neighboring gene microRNA let7i Neighboring gene STARR-positive B cell enhancer ABC_E6936 Neighboring gene ubiquitin specific peptidase 15 Neighboring gene STARR-positive B cell enhancer ABC_E9134 Neighboring gene STARR-positive B cell enhancer ABC_E11464 Neighboring gene predicted gene, 36628 Neighboring gene predicted gene 4129

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development. Quesnel-Vallières M, et al. Genes Dev, 2015 Apr 1. PMID 25838543, Free PMC Article
  2. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  4. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  5. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein MON2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163024.1 → NP_001156496.1  protein MON2 homolog isoform 1

    See identical proteins and their annotated locations for NP_001156496.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA542162, AC153021, AC153911, AK081083, AK086647, BB614144, BE955337, CB244438, CF747261, CF747618, CN528444, CN702930, CV561694, CV563363, CX122556, CX224591
    Consensus CDS
    CCDS48707.1
    UniProtKB/Swiss-Prot
    Q3TRE3, Q80TL7, Q8BTA8, Q8K4V3
    Related
    ENSMUSP00000073462.4, ENSMUST00000073792.11
    Conserved Domains (4) summary
    pfam09324
    Location:870 → 929
    DUF1981; Domain of unknown function (DUF1981)
    pfam12783
    Location:211 → 378
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    pfam16206
    Location:932 → 1706
    Mon2_C; C-terminal region of Mon2 protein
    pfam16213
    Location:9 → 183
    DCB; Dimerization and cyclophilin-binding domain of Mon2

  2. NM_001163025.1 → NP_001156497.1  protein MON2 homolog isoform 2

    See identical proteins and their annotated locations for NP_001156497.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site and lacks two in-frame exons in the coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AA542162, AC153021, AC153911, AK081083, AK086647, BB614144, BE955337, CB244438, CF747261, CF747618, CN525456, CN528444, CN702930, CV561694, CV563363, CX224591
    Consensus CDS
    CCDS48708.1
    UniProtKB/TrEMBL
    B9EKJ3
    Related
    ENSMUSP00000131052.2, ENSMUST00000170935.9
    Conserved Domains (4) summary
    pfam09324
    Location:870 → 929
    DUF1981; Domain of unknown function (DUF1981)
    pfam12783
    Location:211 → 380
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    pfam16206
    Location:932 → 1700
    Mon2_C; C-terminal region of Mon2 protein
    pfam16213
    Location:9 → 183
    DCB; dimerization and cyclophilin-binding domain of Mon2

  3. NM_153395.2 → NP_700444.2  protein MON2 homolog isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons in the coding region compared to variant 1. This results in a shorter protein (isoform 3) compared to isoform 1.
    Source sequence(s)
    AA542162, AC153021, AC153911, AK081083, AK086647, BB614144, BE955337, CB244438, CF747261, CF747618, CN528444, CN702930, CV561694, CV563363, CX224591
    Consensus CDS
    CCDS24216.1
    UniProtKB/Swiss-Prot
    Q80TL7
    Related
    ENSMUSP00000037568.8, ENSMUST00000037557.9
    Conserved Domains (4) summary
    pfam09324
    Location:869 → 928
    DUF1981; Domain of unknown function (DUF1981)
    pfam12783
    Location:211 → 378
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    pfam16206
    Location:931 → 1699
    Mon2_C; C-terminal region of Mon2 protein
    pfam16213
    Location:9 → 183
    DCB; Dimerization and cyclophilin-binding domain of Mon2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    122827965..122913684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513969.5 → XP_006514032.1  protein MON2 homolog isoform X3

    Conserved Domains (4) summary
    pfam09324
    Location:869 → 928
    DUF1981; Domain of unknown function (DUF1981)
    pfam12783
    Location:211 → 378
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    pfam16206
    Location:931 → 1705
    Mon2_C; C-terminal region of Mon2 protein
    pfam16213
    Location:9 → 180
    DCB; dimerization and cyclophilin-binding domain of Mon2

  2. XM_006513968.5 → XP_006514031.1  protein MON2 homolog isoform X2

    Conserved Domains (4) summary
    pfam09324
    Location:870 → 929
    DUF1981; Domain of unknown function (DUF1981)
    pfam12783
    Location:211 → 378
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    pfam16206
    Location:932 → 1706
    Mon2_C; C-terminal region of Mon2 protein
    pfam16213
    Location:9 → 180
    DCB; dimerization and cyclophilin-binding domain of Mon2

  3. XM_006513970.5 → XP_006514033.1  protein MON2 homolog isoform X4

    Conserved Domains (4) summary
    pfam09324
    Location:871 → 930
    DUF1981; Domain of unknown function (DUF1981)
    pfam12783
    Location:211 → 378
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    pfam16206
    Location:933 → 1701
    Mon2_C; C-terminal region of Mon2 protein
    pfam16213
    Location:9 → 180
    DCB; dimerization and cyclophilin-binding domain of Mon2

  4. XM_011243533.4 → XP_011241835.1  protein MON2 homolog isoform X1

    Conserved Domains (4) summary
    pfam09324
    Location:871 → 930
    DUF1981; Domain of unknown function (DUF1981)
    pfam12783
    Location:211 → 378
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    pfam16206
    Location:933 → 1707
    Mon2_C; C-terminal region of Mon2 protein
    pfam16213
    Location:9 → 180
    DCB; dimerization and cyclophilin-binding domain of Mon2

  5. XM_017314065.3 → XP_017169554.1  protein MON2 homolog isoform X5

    Conserved Domains (4) summary
    pfam09324
    Location:799 → 858
    DUF1981; Domain of unknown function (DUF1981)
    pfam12783
    Location:139 → 306
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    pfam16206
    Location:861 → 1635
    Mon2_C; C-terminal region of Mon2 protein
    pfam16213
    Location:1 → 108
    DCB; dimerization and cyclophilin-binding domain of Mon2

  6. XM_006513972.4 → XP_006514035.1  protein MON2 homolog isoform X6

    Conserved Domains (2) summary
    pfam09324
    Location:286 → 345
    DUF1981; Domain of unknown function (DUF1981)
    pfam16206
    Location:348 → 1122
    Mon2_C; C-terminal region of Mon2 protein

RNA

  1. XR_380429.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80TL7.2 GenPept UniProtKB/Swiss-Prot:Q80TL7

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