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Yaf2 YY1 associated factor 2 [ Mus musculus (house mouse) ]

Gene ID: 67057, updated on 5-Mar-2024

Summary

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Official Symbol
Yaf2provided by MGI
Official Full Name
YY1 associated factor 2provided by MGI
Primary source
MGI:MGI:1914307
See related
Ensembl:ENSMUSG00000022634 AllianceGenome:MGI:1914307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810021M11Rik
Summary
Predicted to enable DNA binding activity; transcription coactivator activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription, DNA-templated and positive regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including cranial ganglion; early conceptus; embryo mesenchyme; genitourinary system; and heart. Orthologous to human YAF2 (YY1 associated factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 27.2), frontal lobe adult (RPKM 27.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Yaf2 in Genome Data Viewer
Location:
15 E3; 15 47.39 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (93181714..93234816, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (93283833..93336935, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38535 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene glucoside xylosyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E945 Neighboring gene predicted gene, 52193 Neighboring gene predicted gene, 26371 Neighboring gene STARR-seq mESC enhancer starr_39524 Neighboring gene zinc finger CCHC-type and RNA binding motif 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division. Zhao J, et al. Nat Cell Biol, 2020 Apr. PMID 32203418
  2. Dietary xenosterols lead to infertility and loss of abdominal adipose tissue in sterolin-deficient mice. Solca C, et al. J Lipid Res, 2013 Feb. PMID 23180829, Free PMC Article
  3. Characterization of non-canonical Polycomb Repressive Complex 1 subunits during early mouse embryogenesis. Eid A, et al. Epigenetics, 2016 Jun 2. PMID 27081692, Free PMC Article
  4. The mouse YAF2 gene generates two distinct transcripts and is expressed in pre-and postimplantation embryos. Kaneko T, et al. Gene, 2003 Oct 2. PMID 14557078
  5. RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes. Rose NR, et al. Elife, 2016 Oct 5. PMID 27705745, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional dissection of PRC1 subunits RYBP and YAF2 during neural differentiation of embryonic stem cells.
    Title: Functional dissection of PRC1 subunits RYBP and YAF2 during neural differentiation of embryonic stem cells.
  2. The results suggest that histone H1-dependent chromatin compaction plays a critical role in the stable propagation of H2AK119ub1 by RYBP/YAF2-PRC1 during cell division.
    Title: RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division.
  3. Yaf2 acts as a functional, likely molecular, link between YY1 and the Polycomb proteins. It is proposed to mediate the DNA binding activity of YY1 and recruitment of Polycomb proteins to the regulatory region of target genes.
    Title: PcG recruitment by the YY1 REPO domain can be mediated by Yaf2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
YY1-associated factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024189.6 → NP_077151.3  YY1-associated factor 2

    See identical proteins and their annotated locations for NP_077151.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and is protein-coding.
    Source sequence(s)
    AK011702, AK148634
    Consensus CDS
    CCDS27765.1
    UniProtKB/Swiss-Prot
    Q3UFD4, Q99LW6, Q9DBE4
    Related
    ENSMUSP00000079179.7, ENSMUST00000080299.7
    Conserved Domains (2) summary
    sd00029
    Location:23 → 42
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:20 → 43
    zf-RanBP; Zn-finger in Ran binding protein and others

RNA

  1. NR_028315.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon resulting in a frameshift and early stop codon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK011702, AK148634
    Related
    ENSMUST00000133736.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    93181714..93234816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521292.4 → XP_006521355.1  YY1-associated factor 2 isoform X1

    Conserved Domains (3) summary
    sd00029
    Location:23 → 42
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:20 → 43
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam17219
    Location:126 → 156
    YAF2_RYBP; Yaf2/RYBP C-terminal binding motif
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LW6.1 GenPept UniProtKB/Swiss-Prot:Q99LW6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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