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Rexo1 REX1, RNA exonuclease 1 [ Mus musculus (house mouse) ]

Gene ID: 66932, updated on 11-Apr-2024

Summary

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Official Symbol
Rexo1provided by MGI
Official Full Name
REX1, RNA exonuclease 1provided by MGI
Primary source
MGI:MGI:1914182
See related
Ensembl:ENSMUSG00000047417 AllianceGenome:MGI:1914182
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rex1; EloA-BP1; Tceb3bp1; 1700021P10Rik; 2610511M11Rik
Summary
Predicted to enable exonuclease activity. Predicted to be located in nuclear body. Predicted to be active in nucleus. Is expressed in central nervous system and retina. Orthologous to several human genes including REXO1 (RNA exonuclease 1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 30.1), testis adult (RPKM 21.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80376759..80400624, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80540926..80564790, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene one cut domain, family member 3 Neighboring gene ATPase, class I, type 8B, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1124 Neighboring gene predicted gene, 31057 Neighboring gene STARR-positive B cell enhancer ABC_E10628 Neighboring gene STARR-positive B cell enhancer mm9_chr10:80032416-80032717 Neighboring gene Kruppel-like transcription factor 16 Neighboring gene STARR-positive B cell enhancer ABC_E11446 Neighboring gene predicted gene, 26710

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA exonuclease 1 homolog
Names
REX1, RNA exonuclease 1 homolog
elongin A binding protein 1
transcription elongation factor B polypeptide 3 binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025852.4 → NP_080128.2  RNA exonuclease 1 homolog

    See identical proteins and their annotated locations for NP_080128.2

    Status: VALIDATED

    Source sequence(s)
    AC152058
    Consensus CDS
    CCDS24025.1
    UniProtKB/Swiss-Prot
    Q3UMP1, Q69ZR0, Q6NSQ6, Q6PI95, Q7TT28, Q9DA29
    Related
    ENSMUSP00000049705.9, ENSMUST00000057910.16
    Conserved Domains (2) summary
    cd06145
    Location:1053 → 1201
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    pfam15870
    Location:794 → 954
    EloA-BP1; ElonginA binding-protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80376759..80400624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513961.4 → XP_006514024.1  RNA exonuclease 1 homolog isoform X2

    See identical proteins and their annotated locations for XP_006514024.1

    Conserved Domains (3) summary
    cd06145
    Location:1061 → 1209
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    PHA03307
    Location:150 → 461
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15870
    Location:794 → 962
    EloA-BP1; ElonginA binding-protein 1

  2. XM_011243531.3 → XP_011241833.1  RNA exonuclease 1 homolog isoform X3

    Conserved Domains (3) summary
    cd06145
    Location:1060 → 1208
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    PHA03307
    Location:150 → 461
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15870
    Location:794 → 961
    EloA-BP1; ElonginA binding-protein 1

  3. XM_011243530.3 → XP_011241832.1  RNA exonuclease 1 homolog isoform X1

    Conserved Domains (3) summary
    cd06145
    Location:1068 → 1216
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    PHA03307
    Location:150 → 461
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15870
    Location:794 → 969
    EloA-BP1; ElonginA binding-protein 1

RNA

  1. XR_004936252.1 RNA Sequence

  2. XR_004936251.1 RNA Sequence

  3. XR_004936255.1 RNA Sequence

  4. XR_003948775.1 RNA Sequence

  5. XR_871724.3 RNA Sequence

  6. XR_004936253.1 RNA Sequence

  7. XR_004936254.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TT28.1 GenPept UniProtKB/Swiss-Prot:Q7TT28

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