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Rsrc1 arginine/serine-rich coiled-coil 1 [ Mus musculus (house mouse) ]

Gene ID: 66880, updated on 2-Apr-2024

Summary

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Official Symbol
Rsrc1provided by MGI
Official Full Name
arginine/serine-rich coiled-coil 1provided by MGI
Primary source
MGI:MGI:1914130
See related
Ensembl:ENSMUSG00000034544 AllianceGenome:MGI:1914130
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SRrp53; 1200013F24Rik
Summary
Acts upstream of or within several processes, including alternative mRNA splicing, via spliceosome; nucleocytoplasmic transport; and response to antibiotic. Located in cytoplasm and nuclear speck. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human RSRC1 (arginine and serine rich coiled-coil 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 7.3), thymus adult (RPKM 7.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 E1; 3 30.77 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (66888694..67265736)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (66981364..67358403)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07879 Neighboring gene predicted gene, 54200 Neighboring gene STARR-seq mESC enhancer starr_07880 Neighboring gene STARR-seq mESC enhancer starr_07881 Neighboring gene STARR-seq mESC enhancer starr_07882 Neighboring gene Shox2 limb hindbrain control region Neighboring gene aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07883 Neighboring gene SHOX homeobox 2 Neighboring gene predicted gene, 54201 Neighboring gene STARR-seq mESC enhancer starr_07884 Neighboring gene predicted gene, 22295 Neighboring gene STARR-positive B cell enhancer ABC_E6060 Neighboring gene STARR-positive B cell enhancer mm9_chr3:67177807-67178108 Neighboring gene myeloid leukemia factor 1 Neighboring gene G elongation factor, mitochondrial 1 Neighboring gene latexin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Enhancer redundancy provides phenotypic robustness in mammalian development. Osterwalder M, et al. Nature, 2018 Feb 8. PMID 29420474, Free PMC Article
  2. Shox2 function couples neural, muscular and skeletal development in the proximal forelimb. Vickerman L, et al. Dev Biol, 2011 Feb 15. PMID 21156168
  3. A novel SR-related protein is required for the second step of Pre-mRNA splicing. Cazalla D, et al. Mol Cell Biol, 2005 Apr. PMID 15798186, Free PMC Article
  4. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  5. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SRrp53 is a novel SR-related protein that has a role both in constitutive and in alternative splicing.
    Title: A novel SR-related protein is required for the second step of Pre-mRNA splicing.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC103357

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nucleocytoplasmic transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to antibiotic IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/Arginine-related protein 53
Names
arginine/serine-rich coiled-coil protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356273.2 → NP_001343202.1  serine/Arginine-related protein 53 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122870, AC129294, AC134448, AC161425
    UniProtKB/TrEMBL
    Q80XR9

  2. NM_001356274.2 → NP_001343203.1  serine/Arginine-related protein 53 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122870, AC129294, AC134448, AC161425
    UniProtKB/TrEMBL
    Q80XR9

  3. NM_001356275.2 → NP_001343204.1  serine/Arginine-related protein 53 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122870, AC129294, AC134448, AC161425
    Consensus CDS
    CCDS89635.1
    UniProtKB/TrEMBL
    Q3TGY1, Q8CFJ0
    Related
    ENSMUSP00000047077.7, ENSMUST00000046542.13

  4. NM_001356277.2 → NP_001343206.1  serine/Arginine-related protein 53 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC122870, AC129294, AC134448, AC161425
    UniProtKB/TrEMBL
    Q8CFJ0

  5. NM_001356278.2 → NP_001343207.1  serine/Arginine-related protein 53 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC122870, AC129294, AC134448, AC161425
    Consensus CDS
    CCDS89634.1
    UniProtKB/TrEMBL
    E9Q6P8, Q8CFJ0
    Related
    ENSMUSP00000125547.2, ENSMUST00000162693.8

  6. NM_001356279.2 → NP_001343208.1  serine/Arginine-related protein 53 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC122870, AC129294, AC134448, AC161425
    UniProtKB/TrEMBL
    Q8CFJ0

  7. NM_001356280.2 → NP_001343209.1  serine/Arginine-related protein 53 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC122870, AC129294, AC134448, AC161425
    UniProtKB/TrEMBL
    Q8BR75

  8. NM_025822.5 → NP_080098.1  serine/Arginine-related protein 53 isoform 2

    See identical proteins and their annotated locations for NP_080098.1

    Status: VALIDATED

    Source sequence(s)
    AC122870, AC129294, AC134448, AC161425
    Consensus CDS
    CCDS17394.1
    UniProtKB/Swiss-Prot
    Q3TF06, Q9DBU6
    UniProtKB/TrEMBL
    Q80XR9
    Related
    ENSMUSP00000066797.8, ENSMUST00000065074.14

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    66888694..67265736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163232.1 → XP_036019125.1  serine/Arginine-related protein 53 isoform X5

  2. XM_017319694.3 → XP_017175183.1  serine/Arginine-related protein 53 isoform X1

    UniProtKB/TrEMBL
    Q9CSR8

  3. XM_036163231.1 → XP_036019124.1  serine/Arginine-related protein 53 isoform X3

  4. XM_017319692.3 → XP_017175181.1  serine/Arginine-related protein 53 isoform X1

    UniProtKB/TrEMBL
    Q9CSR8

  5. XM_006501911.5 → XP_006501974.1  serine/Arginine-related protein 53 isoform X4

  6. XM_006501913.5 → XP_006501976.1  serine/Arginine-related protein 53 isoform X5

  7. XM_011240198.3 → XP_011238500.2  serine/Arginine-related protein 53 isoform X2

    Conserved Domains (1) summary
    pfam18697
    Location:139 → 216
    MLVIN_C; Murine leukemia virus (MLV) integrase (IN) C-terminal domain

  8. XM_017319693.3 → XP_017175182.1  serine/Arginine-related protein 53 isoform X1

    UniProtKB/TrEMBL
    Q9CSR8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBU6.1 GenPept UniProtKB/Swiss-Prot:Q9DBU6

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