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Tcf25 transcription factor 25 (basic helix-loop-helix) [ Mus musculus (house mouse) ]

Gene ID: 66855, updated on 5-Mar-2024

Summary

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Official Symbol
Tcf25provided by MGI
Official Full Name
transcription factor 25 (basic helix-loop-helix)provided by MGI
Primary source
MGI:MGI:1914105
See related
Ensembl:ENSMUSG00000001472 AllianceGenome:MGI:1914105
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nulp1; mKIAA1049; D8Ertd325e; 1100001J13Rik; 1810041K11Rik
Summary
Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; cranium; genitourinary system; nervous system; and skin. Orthologous to human TCF25 (transcription factor 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 101.0), cortex adult (RPKM 91.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 72.1 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (124097511..124130913)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123370772..123404174)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein (C2H2 type) 276 Neighboring gene Fanconi anemia, complementation group A Neighboring gene STARR-positive B cell enhancer ABC_E8971 Neighboring gene STARR-seq mESC enhancer starr_22969 Neighboring gene STARR-seq mESC enhancer starr_22970 Neighboring gene spire type actin nucleation factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E2278 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:125928490-125928752 Neighboring gene STARR-seq mESC enhancer starr_22972 Neighboring gene melanocortin 1 receptor Neighboring gene tubulin, beta 3 class III

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nulp1, a novel basic helix-loop-helix protein expressed broadly during early embryonic organogenesis and prominently in developing dorsal root ganglia. Olsson M, et al. Cell Tissue Res, 2002 Jun. PMID 12107429
  2. NULP1 Alleviates Cardiac Hypertrophy by Suppressing NFAT3 Transcriptional Activity. Zhang X, et al. J Am Heart Assoc, 2020 Aug 18. PMID 32805187, Free PMC Article
  3. Molecular and functional analyses of the human and mouse genes encoding AFG3L1, a mitochondrial metalloprotease homologous to the human spastic paraplegia protein. Kremmidiotis G, et al. Genomics, 2001 Aug. PMID 11549317
  4. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809
  5. Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism. Valdez-Sinon AN, et al. iScience, 2020 May 22. PMID 32434143, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of RQC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RQC complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribosome quality control complex subunit TCF25
Names
nuclear localized protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037877.4 → NP_001032966.1  ribosome quality control complex subunit TCF25 isoform a

    See identical proteins and their annotated locations for NP_001032966.1

    Status: VALIDATED

    Source sequence(s)
    AC122266
    Consensus CDS
    CCDS52700.1
    UniProtKB/TrEMBL
    A0A1D5RM90
    Related
    ENSMUSP00000104468.3, ENSMUST00000108840.4
    Conserved Domains (1) summary
    pfam04910
    Location:248 → 588
    Tcf25; Transcriptional repressor TCF25

  2. NM_001037878.5 → NP_001032967.1  ribosome quality control complex subunit TCF25 isoform c

    See identical proteins and their annotated locations for NP_001032967.1

    Status: VALIDATED

    Source sequence(s)
    AC122266
    Consensus CDS
    CCDS22755.1
    UniProtKB/Swiss-Prot
    Q3THR8, Q3UBI7, Q3UD64, Q3UG75, Q80ZX3, Q8BR80, Q8C200, Q8C2M3, Q8C6B4, Q8R3L2, Q9CUW0, Q9ER19
    UniProtKB/TrEMBL
    A0A1D5RM90
    Related
    ENSMUSP00000056485.4, ENSMUST00000057934.10
    Conserved Domains (1) summary
    pfam04910
    Location:248 → 588
    Tcf25; Transcriptional repressor TCF25

  3. NM_001286362.2 → NP_001273291.1  ribosome quality control complex subunit TCF25 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC122266
    Consensus CDS
    CCDS85631.1
    UniProtKB/TrEMBL
    A0A1D5RM90
    Related
    ENSMUSP00000148344.2, ENSMUST00000212470.2
    Conserved Domains (1) summary
    pfam04910
    Location:223 → 563
    Tcf25; Transcriptional repressor TCF25

  4. NM_001286363.3 → NP_001273292.1  ribosome quality control complex subunit TCF25 isoform e

    See identical proteins and their annotated locations for NP_001273292.1

    Status: VALIDATED

    Source sequence(s)
    AC122266
    UniProtKB/TrEMBL
    A0A1D5RM90, B2ZAC8
    Related
    ENSMUSP00000148454.2, ENSMUST00000212569.2
    Conserved Domains (1) summary
    pfam04910
    Location:223 → 563
    Tcf25; Transcriptional repressor TCF25

  5. NM_001359075.2 → NP_001346004.1  ribosome quality control complex subunit TCF25 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC122266
    UniProtKB/TrEMBL
    A0A1D5RM90
    Conserved Domains (1) summary
    pfam04910
    Location:248 → 588
    Tcf25; Transcriptional repressor TCF25

  6. NM_001359076.2 → NP_001346005.1  ribosome quality control complex subunit TCF25 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC122266
    UniProtKB/TrEMBL
    A0A1D5RM90
    Conserved Domains (1) summary
    pfam04910
    Location:223 → 563
    Tcf25; Transcriptional repressor TCF25

  7. NM_025804.3 → NP_080080.2  ribosome quality control complex subunit TCF25 isoform b

    See identical proteins and their annotated locations for NP_080080.2

    Status: VALIDATED

    Source sequence(s)
    BC046768, BE993156, BY080269
    Consensus CDS
    CCDS85630.1
    UniProtKB/TrEMBL
    A0A1D5RM90
    Related
    ENSMUSP00000148531.2, ENSMUST00000212571.2
    Conserved Domains (1) summary
    pfam04910
    Location:248 → 588
    Tcf25; Transcriptional repressor TCF25

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    124097511..124130913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531296.5 → XP_006531359.1  ribosome quality control complex subunit TCF25 isoform X1

    UniProtKB/TrEMBL
    A0A1D5RM90
    Related
    ENSMUSP00000148676.2, ENSMUST00000211932.2
    Conserved Domains (1) summary
    pfam04910
    Location:248 → 588
    Tcf25; Transcriptional repressor TCF25

  2. XM_006531297.2 → XP_006531360.1  ribosome quality control complex subunit TCF25 isoform X2

    UniProtKB/TrEMBL
    A0A1D5RM90
    Conserved Domains (1) summary
    pfam04910
    Location:248 → 588
    Tcf25; Transcriptional repressor TCF25

  3. XM_011248487.2 → XP_011246789.1  ribosome quality control complex subunit TCF25 isoform X3

    UniProtKB/TrEMBL
    A0A1D5RM90
    Conserved Domains (1) summary
    pfam04910
    Location:248 → 588
    Tcf25; Transcriptional repressor TCF25

  4. XM_030243730.1 → XP_030099590.1  ribosome quality control complex subunit TCF25 isoform X4

    UniProtKB/TrEMBL
    A0A1D5RM90
    Conserved Domains (1) summary
    pfam04910
    Location:248 → 588
    Tcf25; Transcriptional repressor TCF25

  5. XM_006531298.4 → XP_006531361.1  ribosome quality control complex subunit TCF25 isoform X5

    UniProtKB/TrEMBL
    A0A1D5RM90
    Conserved Domains (1) summary
    pfam04910
    Location:223 → 563
    Tcf25; Transcriptional repressor TCF25
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R3L2.2 GenPept UniProtKB/Swiss-Prot:Q8R3L2

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