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Emc2 ER membrane protein complex subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 66736, updated on 5-Mar-2024

Summary

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Official Symbol
Emc2provided by MGI
Official Full Name
ER membrane protein complex subunit 2provided by MGI
Primary source
MGI:MGI:1913986
See related
Ensembl:ENSMUSG00000022337 AllianceGenome:MGI:1913986
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ttc35; 4921531G14Rik
Summary
Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Located in mitochondrion. Orthologous to human EMC2 (ER membrane protein complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 27.1), cerebellum adult (RPKM 21.2) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 B3.2; 15 16.75 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (43340603..43391174)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (43477229..43527777)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33743 Neighboring gene predicted gene 10373 Neighboring gene STARR-positive B cell enhancer mm9_chr15:43308481-43308782 Neighboring gene STARR-seq mESC enhancer starr_38553 Neighboring gene STARR-seq mESC enhancer starr_38554 Neighboring gene predicted gene, 53880 Neighboring gene predicted gene, 41316 Neighboring gene STARR-seq mESC enhancer starr_38556 Neighboring gene STARR-seq mESC enhancer starr_38557 Neighboring gene STARR-seq mESC enhancer starr_38558 Neighboring gene STARR-seq mESC enhancer starr_38559 Neighboring gene SUMO-conjugating enzyme UBC9 pseudogene Neighboring gene transmembrane protein 74

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane. Dreger M, et al. Proc Natl Acad Sci U S A, 2001 Oct 9. PMID 11593002, Free PMC Article
  2. The ER membrane protein complex is a transmembrane domain insertase. Guna A, et al. Science, 2018 Jan 26. PMID 29242231, Free PMC Article
  3. High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Ehringer MA, et al. Mamm Genome, 2001 Aug. PMID 11471062
  4. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Wang X, et al. Cell, 2006 Nov 17. PMID 17110338
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to membrane insertase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence ISO
Inferred from Sequence Orthology
more info
  
involved_in tail-anchored membrane protein insertion into ER membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of EMC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of EMC complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extrinsic component of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
ER membrane protein complex subunit 2
Names
TPR repeat protein 35
tetratricopeptide repeat domain 35
tetratricopeptide repeat protein 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418323.1 → NP_001405252.1  ER membrane protein complex subunit 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC099614, AC099621

  2. NM_001418325.1 → NP_001405254.1  ER membrane protein complex subunit 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC099614, AC099621

  3. NM_001418326.1 → NP_001405255.1  ER membrane protein complex subunit 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC099614, AC099621

  4. NM_025736.3 → NP_080012.1  ER membrane protein complex subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_080012.1

    Status: VALIDATED

    Source sequence(s)
    AC099614, AC099621
    Consensus CDS
    CCDS27453.1
    UniProtKB/Swiss-Prot
    Q925K1, Q9CRD2
    UniProtKB/TrEMBL
    Q6A0D1
    Related
    ENSMUSP00000022962.7, ENSMUST00000022962.8
    Conserved Domains (4) summary
    sd00006
    Location:120 → 150
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:156 → 222
    TPR_11; TPR repeat
    pfam13432
    Location:62 → 121
    TPR_16; Tetratricopeptide repeat
    pfam14559
    Location:99 → 164
    TPR_19; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    43340603..43391174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004938861.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CRD2.1 GenPept UniProtKB/Swiss-Prot:Q9CRD2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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