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Blzf1 basic leucine zipper nuclear factor 1 [ Mus musculus (house mouse) ]

Gene ID: 66352, updated on 30-Apr-2024

Summary

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Official Symbol
Blzf1provided by MGI
Official Full Name
basic leucine zipper nuclear factor 1provided by MGI
Primary source
MGI:MGI:1201607
See related
Ensembl:ENSMUSG00000026577 AllianceGenome:MGI:1201607
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Jem-1; Blzf1l; Golgin-45; 1700030G05Rik
Summary
Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in Golgi organization and Golgi to plasma membrane protein transport. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Located in Golgi apparatus. Orthologous to human BLZF1 (basic leucine zipper nuclear factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 5.4), bladder adult (RPKM 4.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Blzf1 in Genome Data Viewer
Location:
1 H2.2; 1 71.6 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (164117368..164135056, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (164289799..164307487, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02865 Neighboring gene STARR-seq mESC enhancer starr_02866 Neighboring gene solute carrier family 19 (thiamine transporter), member 2 Neighboring gene STARR-seq mESC enhancer starr_02867 Neighboring gene coiled-coil domain containing 181 Neighboring gene STARR-positive B cell enhancer ABC_E797 Neighboring gene NME/NM23 family member 7 Neighboring gene STARR-positive B cell enhancer ABC_E5840 Neighboring gene STARR-seq mESC enhancer starr_02870 Neighboring gene predicted gene, 39690 Neighboring gene ATPase, Na+/K+ transporting, beta 1 polypeptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. JEM-1, a novel gene encoding a leucine-zipper nuclear factor upregulated during retinoid-induced maturation of NB4 promyelocytic leukaemia. Duprez E, et al. Oncogene, 1997 Apr 3. PMID 9129147
  2. A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic. Short B, et al. J Cell Biol, 2001 Dec 10. PMID 11739401, Free PMC Article
  3. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Pilot-Storck F, et al. Mol Cell Proteomics, 2010 Jul. PMID 20368287, Free PMC Article
  4. Network organization of the huntingtin proteomic interactome in mammalian brain. Shirasaki DI, et al. Neuron, 2012 Jul 12. PMID 22794259, Free PMC Article
  5. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi to plasma membrane protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Golgi to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
golgin-45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160208.1 → NP_001153680.1  golgin-45 isoform b

    See identical proteins and their annotated locations for NP_001153680.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode isoform b.
    Source sequence(s)
    AC105161, AK006544, AK029787
    Consensus CDS
    CCDS48423.1
    UniProtKB/Swiss-Prot
    Q3TJC4, Q8C0U6, Q8R2X8, Q9DAV7
    UniProtKB/TrEMBL
    Q3TBM0, Q3V485
    Related
    ENSMUSP00000083196.4, ENSMUST00000086032.4
    Conserved Domains (1) summary
    pfam08227
    Location:184 → 229
    DASH_Hsk3; DASH complex subunit Hsk3 like

  2. NM_001160209.1 → NP_001153681.1  golgin-45 isoform b

    See identical proteins and their annotated locations for NP_001153681.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and differs in the 5' UTR compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode isoform b.
    Source sequence(s)
    AC105161, AK029787, AK167493
    Consensus CDS
    CCDS48423.1
    UniProtKB/Swiss-Prot
    Q3TJC4, Q8C0U6, Q8R2X8, Q9DAV7
    UniProtKB/TrEMBL
    Q3TBM0, Q3V485
    Related
    ENSMUSP00000113479.2, ENSMUST00000120447.8
    Conserved Domains (1) summary
    pfam08227
    Location:184 → 229
    DASH_Hsk3; DASH complex subunit Hsk3 like

  3. NM_001357052.1 → NP_001343981.1  golgin-45 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC105161
    UniProtKB/TrEMBL
    Q3V485
    Conserved Domains (2) summary
    pfam08227
    Location:157 → 202
    DASH_Hsk3; DASH complex subunit Hsk3 like
    cl25732
    Location:76 → 247
    SMC_N; RecF/RecN/SMC N terminal domain

  4. NM_025505.4 → NP_079781.2  golgin-45 isoform a

    See identical proteins and their annotated locations for NP_079781.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC105161, AK029787
    Consensus CDS
    CCDS15435.1
    UniProtKB/TrEMBL
    Q3TBM0, Q3V485
    Related
    ENSMUSP00000027866.5, ENSMUST00000027866.11
    Conserved Domains (1) summary
    pfam08227
    Location:191 → 236
    DASH_Hsk3; DASH complex subunit Hsk3 like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    164117368..164135056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R2X8.2 GenPept UniProtKB/Swiss-Prot:Q8R2X8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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