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Pla2g12a phospholipase A2, group XIIA [ Mus musculus (house mouse) ]

Gene ID: 66350, updated on 5-Mar-2024

Summary

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Official Symbol
Pla2g12aprovided by MGI
Official Full Name
phospholipase A2, group XIIAprovided by MGI
Primary source
MGI:MGI:1913600
See related
Ensembl:ENSMUSG00000027999 AllianceGenome:MGI:1913600
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GXII; Rossy; GXII-1; Pla2g12; mGXII-1; GXII-1-PLA2; 2310004B05Rik
Summary
Enables phospholipase A2 activity. Predicted to be involved in arachidonic acid secretion and phospholipid metabolic process. Predicted to act upstream of or within lipid catabolic process. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PLA2G12A (phospholipase A2 group XIIA). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 52.5), ovary adult (RPKM 43.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pla2g12a in Genome Data Viewer
Location:
3 G3; 3 59.4 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (129672255..129689474)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (129878606..129895825)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7942 Neighboring gene GAR1 ribonucleoprotein Neighboring gene complement component factor i Neighboring gene predicted gene, 36180 Neighboring gene predicted gene, 46825 Neighboring gene caspase 6 Neighboring gene predicted gene, 40150

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Induction of ectopic olfactory structures and bone morphogenetic protein inhibition by Rossy, a group XII secreted phospholipase A2. Muñoz-Sanjuán I, et al. Mol Cell Biol, 2005 May. PMID 15831466, Free PMC Article
  2. Quantitative trait locus mapping in mice identifies phospholipase Pla2g12a as novel atherosclerosis modifier. Nicolaou A, et al. Atherosclerosis, 2017 Oct. PMID 28917158
  3. A novel group of phospholipase A2s preferentially expressed in type 2 helper T cells. Ho IC, et al. J Biol Chem, 2001 May 25. PMID 11278438
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Not Applicable (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC58884

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase A2 activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid catabolic process IC
Inferred by Curator
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
group XIIA secretory phospholipase A2
Names
group XII-1 phospholipase A2
group XIIA secreted phospholipase A2
phosphatidylcholine 2-acylhydrolase 12A
NP_001273877.1
NP_075685.2
NP_904359.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286948.1 → NP_001273877.1  group XIIA secretory phospholipase A2 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift compared to variant 1. The encoded protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC111097, AC118620
    Conserved Domains (1) summary
    pfam06951
    Location:27 → 154
    PLA2G12; Group XII secretory phospholipase A2 precursor (PLA2G12)

  2. NM_023196.4 → NP_075685.2  group XIIA secretory phospholipase A2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_075685.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BB505724, BC051117
    Consensus CDS
    CCDS17836.1
    UniProtKB/Swiss-Prot
    Q3TQC4, Q9CQR3, Q9CTL1, Q9D7L3, Q9EPR1, Q9EPR2
    UniProtKB/TrEMBL
    Q6GTY5
    Related
    ENSMUSP00000029629.9, ENSMUST00000029629.15
    Conserved Domains (1) summary
    pfam06951
    Location:27 → 192
    PLA2G12; Group XII secretory phospholipase A2 precursor (PLA2G12)

  3. NM_183423.3 → NP_904359.1  group XIIA secretory phospholipase A2 isoform 2

    See identical proteins and their annotated locations for NP_904359.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, lacks a portion of the 5' coding region and initiates translation at an alternate start codon compared to variant 1. The encoded protein (isoform 2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC111097, AC118620
    Consensus CDS
    CCDS17837.1
    UniProtKB/Swiss-Prot
    Q9EPR2
    Related
    ENSMUSP00000053651.7, ENSMUST00000061165.9
    Conserved Domains (1) summary
    pfam06951
    Location:35 → 153
    PLA2G12; Group XII secretory phospholipase A2 precursor (PLA2G12)

RNA

  1. NR_104611.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC111097, AC118620

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    129672255..129689474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EPR2.2 GenPept UniProtKB/Swiss-Prot:Q9EPR2

Gene LinkOut

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