Mptx1 mucosal pentraxin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mptx1provided by MGI
Official Full Name: mucosal pentraxin 1provided by MGI
Primary source: MGI:MGI:1913539
See related: Ensembl:ENSMUSG00000026531 AllianceGenome:MGI:1913539
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mptx; 1810030J14Rik
Summary: Predicted to enable complement component C1q complex binding activity and low-density lipoprotein particle binding activity. Predicted to be involved in complement activation, classical pathway; innate immune response; and negative regulation by host of viral process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human MPTX1 (mucosal pentraxin 1 (pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 38.8), large intestine adult (RPKM 36.1) and 1 other tissue See more
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Genomic context

Location:: 1 H3; 1 81.01 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (174158085..174160443)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (174330518..174332877)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables complement component C1q complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mucosal pentraxin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025470.4 → NP_079746.1 mucosal pentraxin precursor

See identical proteins and their annotated locations for NP_079746.1

Status: VALIDATED

Source sequence(s)

AC156549

Consensus CDS

CCDS15541.1

UniProtKB/Swiss-Prot

Q8R1M8, Q9D8J8

UniProtKB/TrEMBL

A0A0R4J077

Related

ENSMUSP00000027816.5, ENSMUST00000027816.5

Conserved Domains (1) summary

cd00152
Location:20 → 214

PTX; Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated ...