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Anapc11 anaphase promoting complex subunit 11 [ Mus musculus (house mouse) ]

Gene ID: 66156, updated on 11-Apr-2024

Summary

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Official Symbol
Anapc11provided by MGI
Official Full Name
anaphase promoting complex subunit 11provided by MGI
Primary source
MGI:MGI:1913406
See related
Ensembl:ENSMUSG00000025135 AllianceGenome:MGI:1913406
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110011I19Rik
Summary
Predicted to enable cullin family protein binding activity and ubiquitin-ubiquitin ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in positive regulation of mitotic metaphase/anaphase transition; protein K11-linked ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within cell division. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of anaphase-promoting complex. Predicted to be active in nucleus. Is expressed in several structures, including male reproductive system; nervous system; retina; and urinary system. Orthologous to human ANAPC11 (anaphase promoting complex subunit 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 39.1), ovary adult (RPKM 38.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 84.32 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120489247..120499024)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120598421..120608198)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Rho GDP dissociation inhibitor alpha Neighboring gene predicted gene 3807 Neighboring gene Aly/REF export factor Neighboring gene STARR-positive B cell enhancer ABC_E1854 Neighboring gene neuropeptide B Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene STARR-positive B cell enhancer ABC_E7114

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation. Naoe H, et al. Mol Cell Biol, 2010 Aug. PMID 20530197, Free PMC Article
  2. The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation. Shoji S, et al. FEBS Open Bio, 2014. PMID 25161877, Free PMC Article
  3. APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain. Ferguson CJ, et al. Mol Cell, 2022 Jan 6. PMID 34942119, Free PMC Article
  4. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article
  5. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-ubiquitin ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitotic metaphase/anaphase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
anaphase-promoting complex subunit 11
Names
APC11
anaphase promoting complex subunit 11 homolog
cyclosome subunit 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038230.2 → NP_001033319.1  anaphase-promoting complex subunit 11

    See identical proteins and their annotated locations for NP_001033319.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA269705, AL663030, BY285612
    Consensus CDS
    CCDS25745.1
    UniProtKB/Swiss-Prot
    Q3UWH1, Q9CPX9, Q9CTG0
    Related
    ENSMUSP00000097714.4, ENSMUST00000093140.5
    Conserved Domains (1) summary
    cl17238
    Location:1 → 84
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. NM_025389.4 → NP_079665.1  anaphase-promoting complex subunit 11

    See identical proteins and their annotated locations for NP_079665.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK045408, AL663030
    Consensus CDS
    CCDS25745.1
    UniProtKB/Swiss-Prot
    Q3UWH1, Q9CPX9, Q9CTG0
    Related
    ENSMUSP00000026128.4, ENSMUST00000026128.10
    Conserved Domains (1) summary
    cl17238
    Location:1 → 84
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120489247..120499024
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CPX9.1 GenPept UniProtKB/Swiss-Prot:Q9CPX9

Gene LinkOut

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