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Ufc1 ubiquitin-fold modifier conjugating enzyme 1 [ Mus musculus (house mouse) ]

Gene ID: 66155, updated on 5-Mar-2024

Summary

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Official Symbol
Ufc1provided by MGI
Official Full Name
ubiquitin-fold modifier conjugating enzyme 1provided by MGI
Primary source
MGI:MGI:1913405
See related
Ensembl:ENSMUSG00000062963 AllianceGenome:MGI:1913405
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ESTM29; 1110021H02Rik
Summary
Predicted to enable UFM1 conjugating enzyme activity. Predicted to be involved in several processes, including protein K69-linked ufmylation; response to endoplasmic reticulum stress; and reticulophagy. Is expressed in chondrocranium and liver. Orthologous to human UFC1 (ubiquitin-fold modifier conjugating enzyme 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 26.0), placenta adult (RPKM 25.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H3; 1 79.31 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171116137..171122575, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171288564..171295002, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protoporphyrinogen oxidase Neighboring gene STARR-positive B cell enhancer mm9_chr1:173211225-173211526 Neighboring gene STARR-positive B cell enhancer mm9_chr1:173211857-173212158 Neighboring gene ubiquitin specific peptidase 21 Neighboring gene STARR-seq mESC enhancer starr_03026 Neighboring gene STARR-seq mESC enhancer starr_03027 Neighboring gene ribosomal protein L27, pseudogene 1 Neighboring gene predicted gene, 25151

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ubiquitin-fold modifier 1 inhibits apoptosis by suppressing the endoplasmic reticulum stress response in Raw264.7 cells. Hu X, et al. Int J Mol Med, 2014 Jun. PMID 24714921
  2. Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking. Zhang Y, et al. PLoS One, 2012. PMID 23152784, Free PMC Article
  3. CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development. Yang R, et al. Development, 2019 Jan 25. PMID 30635284
  4. Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Eddleston J, et al. Genomics, 1999 Mar 1. PMID 10051400
  5. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results suggest that Ufm1 is upregulated in diabetic mouse RPMs and in Raw264.7 cells in response to ER stress and that Ufm1 protects macrophages against apoptosis.
    Title: Ubiquitin-fold modifier 1 inhibits apoptosis by suppressing the endoplasmic reticulum stress response in Raw264.7 cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UFM1 conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables UFM1 transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in brain development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K69-linked ufmylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K69-linked ufmylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein ufmylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein ufmylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
involved_in reticulophagy ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin-fold modifier-conjugating enzyme 1
Names
Ufm1-conjugating enzyme 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360931.1 → NP_001347860.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC087229
    Consensus CDS
    CCDS15488.1
    UniProtKB/Swiss-Prot
    Q9CR09
    Related
    ENSMUSP00000106933.4, ENSMUST00000111302.4
    Conserved Domains (1) summary
    pfam08694
    Location:6 → 160
    UFC1; Ubiquitin-fold modifier-conjugating enzyme 1

  2. NM_001360932.1 → NP_001347861.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC087229, AI596556, BE652094
    Consensus CDS
    CCDS15488.1
    UniProtKB/Swiss-Prot
    Q9CR09
    Conserved Domains (1) summary
    pfam08694
    Location:6 → 160
    UFC1; Ubiquitin-fold modifier-conjugating enzyme 1

  3. NM_001360933.1 → NP_001347862.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC087229, AI596556
    Conserved Domains (1) summary
    pfam08694
    Location:6 → 80
    UFC1; Ubiquitin-fold modifier-conjugating enzyme 1

  4. NM_025388.3 → NP_079664.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform a

    See identical proteins and their annotated locations for NP_079664.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AC087229, AK003897
    Consensus CDS
    CCDS15488.1
    UniProtKB/Swiss-Prot
    Q9CR09
    Related
    ENSMUSP00000078914.3, ENSMUST00000080001.9
    Conserved Domains (1) summary
    pfam08694
    Location:6 → 160
    UFC1; Ubiquitin-fold modifier-conjugating enzyme 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    171116137..171122575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CR09.1 GenPept UniProtKB/Swiss-Prot:Q9CR09

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