Ifitm3 interferon induced transmembrane protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifitm3provided by MGI
Official Full Name: interferon induced transmembrane protein 3provided by MGI
Primary source: MGI:MGI:1913391
See related: Ensembl:ENSMUSG00000025492 AllianceGenome:MGI:1913391
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fgls; IP15; Cd225; mil-1; Cdw217; DSPA2b; 1110004C05Rik
Summary: Involved in negative regulation of viral entry into host cell and response to virus. Acts upstream of or within defense response to other organism; negative regulation of cell population proliferation; and receptor-mediated endocytosis. Located in several cellular components, including apical part of cell; cell surface; and endoplasmic reticulum. Is expressed in several structures, including alimentary system; egg cylinder; embryo ectoderm; genitourinary system; and mesenchyme derived from lateral plate. Human ortholog(s) of this gene implicated in COVID-19; adenosquamous gallbladder carcinoma; and gallbladder adenocarcinoma. Orthologous to several human genes including IFITM3 (interferon induced transmembrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver adult (RPKM 350.2), subcutaneous fat pad adult (RPKM 292.7) and 19 other tissues See more
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Genomic context

Location:: 7 F5; 7 86.25 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (140589503..140590657, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (141009590..141010744, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Low-dose-rate ionizing radiation affects innate immunity protein IFITM3 in a mouse model of Alzheimer's disease.
Title: Low-dose-rate ionizing radiation affects innate immunity protein IFITM3 in a mouse model of Alzheimer's disease.
Interferon-induced transmembrane protein 3 (IFITM3) limits lethality of SARS-CoV-2 in mice.
Title: Interferon-induced transmembrane protein 3 (IFITM3) limits lethality of SARS-CoV-2 in mice.
IFITM3 regulates fibrinogen endocytosis and platelet reactivity in nonviral sepsis.
Title: IFITM3 regulates fibrinogen endocytosis and platelet reactivity in nonviral sepsis.
Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes.
Title: Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes.
The innate immunity protein IFITM3 modulates gamma-secretase in Alzheimer's disease.
Title: The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease.
IFITM3 deficiency in a new knockout (KO) mouse model increases weight loss and mortality following influenza virus infections. Infected IFITM3 KO mice developed aberrant cardiac electrical activity, including decreased heart rate and irregular, arrhythmic RR (interbeat) intervals. Findings reveal an essential role for IFITM3 in limiting influenza virus replication and pathogenesis in heart tissue.
Title: IFITM3 protects the heart during influenza virus infection.
Study in influenza virus infection mouse models found that Ifitm3 is rapidly up-regulated by T cells following their activation and this occurred independently of type I and II interferon and the interferon regulatory factors 3 and 7. Up-regulation of Ifitm3 on effector T cells protected these cells from virus infection and imparted a survival advantage at sites of virus infection.
Title: Rapid interferon independent expression of IFITM3 following T cell activation protects cells from influenza virus infection.
this study shows that IFITM3 drives type 2 T helper cell differentiation and exacerbate allergic airway inflammation
Title: IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation.
the role of IFITM3 in colonic epithelial homeostasis, inflammation and colitis-associated tumorigenesis using IFITM3-deficient mice, was investigated.
Title: The anti-inflammatory IFITM genes ameliorate colitis and partially protect from tumorigenesis by changing immunity and microbiota.
The extracellular level of Fstl1 is regulated by Ifitm3 in astrocytes, which could be involved in polyI:C-induced neurodevelopmental impairment.
Title: Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC208779P2 (e-PCR)
- UniSTS:271982

Fgls-pending (e-PCR), detects polymorphism
- UniSTS:257226

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to virus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to virus	ISO Inferred from Sequence Orthology more info	PubMed
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of viral entry into host cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of viral entry into host cell	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to interferon-alpha	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to interferon-alpha	ISO Inferred from Sequence Orthology more info
involved_in response to interferon-beta	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in response to type II interferon	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within type I interferon-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: interferon-induced transmembrane protein 3

Names: dispanin subfamily A member 2b; fragilis protein; ifitm-like protein 1; interferon-inducible protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.