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Ranbp17 RAN binding protein 17 [ Mus musculus (house mouse) ]

Gene ID: 66011, updated on 11-Apr-2024

Summary

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Official Symbol
Ranbp17provided by MGI
Official Full Name
RAN binding protein 17provided by MGI
Primary source
MGI:MGI:1929706
See related
Ensembl:ENSMUSG00000040594 AllianceGenome:MGI:1929706
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable nuclear export signal receptor activity. Predicted to be involved in protein export from nucleus. Predicted to act upstream of or within nucleocytoplasmic transport. Predicted to be located in nucleus. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. Orthologous to human RANBP17 (RAN binding protein 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 5.0), CNS E11.5 (RPKM 1.1) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A4; 11 19.21 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (33161794..33463789, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (33211794..33513784, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12115 Neighboring gene T cell leukemia, homeobox 3 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene acidic (leucine-rich) nuclear phosphoprotein 32 family, pseudogene Neighboring gene mediator complex subunit 29 pseudogene Neighboring gene high mobility group box 2 pseudogene Neighboring gene CRISPRi-validated Ranbp17 enhancer cluster Neighboring gene STARR-seq mESC enhancer starr_29136 Neighboring gene predicted gene, 36005 Neighboring gene gamma-aminobutyric acid type A receptor subunit pi

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RANBP17 is localized to the XY body of spermatocytes and interacts with SPEM1 on the manchette of elongating spermatids. Bao J, et al. Mol Cell Endocrinol, 2011 Feb 20. PMID 21184802, Free PMC Article
  2. Identification of a novel putative Ran-binding protein and its close homologue. Koch P, et al. Biochem Biophys Res Commun, 2000 Nov 11. PMID 11071879
  3. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interactions between RANBP17 and SPEM1, for the first time, point to a potential function of SPEM1 in the RANBP17-mediated nucleocytoplasmic transport.
    Title: RANBP17 is localized to the XY body of spermatocytes and interacts with SPEM1 on the manchette of elongating spermatids.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • 4932704E15Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear export signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nucleocytoplasmic transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ran-binding protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362875.1 → NP_001349804.1  ran-binding protein 17 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL669814, AL683843, AL772409
    UniProtKB/TrEMBL
    Q8BWS4
    Conserved Domains (2) summary
    smart00913
    Location:30 → 95
    IBN_N; Importin-beta N-terminal domain
    cl26694
    Location:8 → 167
    Xpo1; Exportin 1-like protein

  2. NM_023146.3 → NP_075635.1  ran-binding protein 17 isoform 1

    See identical proteins and their annotated locations for NP_075635.1

    Status: VALIDATED

    Source sequence(s)
    AK016583, AL669814, AL683843, AL772409, BY731762
    Consensus CDS
    CCDS24534.1
    UniProtKB/Swiss-Prot
    Q99NF8, Q9D4E3
    UniProtKB/TrEMBL
    Q8BWS4
    Related
    ENSMUSP00000099879.4, ENSMUST00000102815.10
    Conserved Domains (1) summary
    pfam03810
    Location:30 → 95
    IBN_N; Importin-beta N-terminal domain

RNA

  1. NR_110973.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK035897, AK050150, AL669814, AL772409, BY731762, CB527189

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    33161794..33463789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514776.5 → XP_006514839.1  ran-binding protein 17 isoform X1

    UniProtKB/TrEMBL
    Q8BWS4
    Conserved Domains (2) summary
    smart00913
    Location:30 → 95
    IBN_N; Importin-beta N-terminal domain
    COG5101
    Location:8 → 167
    CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

  2. XM_011243739.4 → XP_011242041.1  ran-binding protein 17 isoform X2

    UniProtKB/TrEMBL
    Q8BWS4
    Conserved Domains (2) summary
    smart00913
    Location:30 → 95
    IBN_N; Importin-beta N-terminal domain
    COG5101
    Location:8 → 167
    CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

RNA

  1. XR_380976.5 RNA Sequence

  2. XR_380979.5 RNA Sequence

  3. XR_380977.5 RNA Sequence

  4. XR_003949487.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99NF8.1 GenPept UniProtKB/Swiss-Prot:Q99NF8

Gene LinkOut

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