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SLC2A5 solute carrier family 2 member 5 [ Homo sapiens (human) ]

Gene ID: 6518, updated on 11-Apr-2024

Summary

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Official Symbol
SLC2A5provided by HGNC
Official Full Name
solute carrier family 2 member 5provided by HGNC
Primary source
HGNC:HGNC:11010
See related
Ensembl:ENSG00000142583 MIM:138230; AllianceGenome:HGNC:11010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUT5; GLUT-5
Summary
The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption. [provided by RefSeq, Jun 2016]
Expression
Biased expression in duodenum (RPKM 33.7), small intestine (RPKM 25.5) and 8 other tissues See more
Orthologs
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Genomic context

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See SLC2A5 in Genome Data Viewer
Location:
1p36.23
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (9035106..9094195, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (8568756..8627452, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (9095165..9132318, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9046209-9046710 Neighboring gene RNA, 7SL, cytoplasmic 451, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9048516-9049016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9064340-9064868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9064869-9065395 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9067816-9068316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9068317-9068817 Neighboring gene solute carrier family 2 member 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 111 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 112 Neighboring gene MPRA-validated peak52 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9118073-9118573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 113 Neighboring gene small Cajal body-specific RNA 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9164158-9165134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 114 Neighboring gene MPRA-validated peak53 silencer Neighboring gene G protein-coupled receptor 157 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9181680-9182180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9182181-9182681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 117 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9196849-9197350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9197351-9197850 Neighboring gene Sharpr-MPRA regulatory region 7425 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 119 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:9211645-9211881 Neighboring gene MIR34A host gene Neighboring gene microRNA 34a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Gene variants of the SLC2A5 gene encoding GLUT5, the major fructose transporter, do not contribute to clinical presentation of acquired fructose malabsorption. Taneva I, et al. BMC Gastroenterol, 2022 Apr 6. PMID 35387598, Free PMC Article
  2. SLC2A5 Correlated with Immune Infiltration: A Candidate Diagnostic and Prognostic Biomarker for Lung Adenocarcinoma. Luo L, et al. J Immunol Res, 2021. PMID 34604392, Free PMC Article
  3. GLUT5-mediated fructose utilization drives lung cancer growth by stimulating fatty acid synthesis and AMPK/mTORC1 signaling. Chen WL, et al. JCI Insight, 2020 Feb 13. PMID 32051337, Free PMC Article
  4. An essential role for GLUT5-mediated fructose utilization in exacerbating the malignancy of clear cell renal cell carcinoma. Jin X, et al. Cell Biol Toxicol, 2019 Oct. PMID 31102011
  5. SLC2A5 overexpression in childhood philadelphia chromosome-positive acute lymphoblastic leukaemia. Zhao P, et al. Br J Haematol, 2018 Oct. PMID 30272826

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GLUT5: structure, functions, diseases and potential applications.
    Title: GLUT5: structure, functions, diseases and potential applications.
  2. Fructose promotes angiogenesis by improving vascular endothelial cell function and upregulating VEGF expression in cancer cells.
    Title: Fructose promotes angiogenesis by improving vascular endothelial cell function and upregulating VEGF expression in cancer cells.
  3. Obesity and overweight are linked to increased sodium-glucose cotransporter 1 and glucose transporter 5 levels in duodenum.
    Title: Obesity and overweight are linked to increased sodium-glucose cotransporter 1 and glucose transporter 5 levels in duodenum.
  4. Serum Iba-1, GLUT5, and TSPO in Patients With Diabetic Retinopathy: New Biomarkers for Early Retinal Neurovascular Alterations? A Pilot Study.
    Title: Serum Iba-1, GLUT5, and TSPO in Patients With Diabetic Retinopathy: New Biomarkers for Early Retinal Neurovascular Alterations? A Pilot Study.
  5. GLUT5-KHK axis-mediated fructose metabolism drives proliferation and chemotherapy resistance of colorectal cancer.
    Title: GLUT5-KHK axis-mediated fructose metabolism drives proliferation and chemotherapy resistance of colorectal cancer.
  6. Gene variants of the SLC2A5 gene encoding GLUT5, the major fructose transporter, do not contribute to clinical presentation of acquired fructose malabsorption.
    Title: Gene variants of the SLC2A5 gene encoding GLUT5, the major fructose transporter, do not contribute to clinical presentation of acquired fructose malabsorption.
  7. SLC2A5 Correlated with Immune Infiltration: A Candidate Diagnostic and Prognostic Biomarker for Lung Adenocarcinoma.
    Title: SLC2A5 Correlated with Immune Infiltration: A Candidate Diagnostic and Prognostic Biomarker for Lung Adenocarcinoma.
  8. S100P contributes to promoter demethylation and transcriptional activation of SLC2A5 to promote metastasis in colorectal cancer.
    Title: S100P contributes to promoter demethylation and transcriptional activation of SLC2A5 to promote metastasis in colorectal cancer.
  9. Identification of new GLUT2-selective inhibitors through in silico ligand screening and validation in eukaryotic expression systems.
    Title: Identification of new GLUT2-selective inhibitors through in silico ligand screening and validation in eukaryotic expression systems.
  10. GLUT5 regulation by AKT1/3-miR-125b-5p downregulation induces migratory activity and drug resistance in TLR-modified colorectal cancer cells.
    Title: GLUT5 regulation by AKT1/3-miR-125b-5p downregulation induces migratory activity and drug resistance in TLR-modified colorectal cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fructose binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables fructose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fructose transmembrane transporter activity TAS
Traceable Author Statement
more info
  
enables glucose transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular response to fructose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fructose import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fructose transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glucose transmembrane transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in intestinal hexose absorption TAS
Traceable Author Statement
more info
  
involved_in regulation of systemic arterial blood pressure mediated by a chemical signal ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to fructose ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular exosome HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in sarcolemma ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in specific granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
solute carrier family 2, facilitated glucose transporter member 5
Names
glucose transporter type 5, small intestine
glucose transporter-like protein 5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
testicular tissue protein Li 81

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050918.1 RefSeqGene

    Range
    28773..63302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135585.2 → NP_001129057.1  solute carrier family 2, facilitated glucose transporter member 5 isoform 2

    See identical proteins and their annotated locations for NP_001129057.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL158048, BC035878, DC379829
    Consensus CDS
    CCDS44054.1
    UniProtKB/TrEMBL
    A0A140VJK5
    Related
    ENSP00000366631.3, ENST00000377414.7
    Conserved Domains (1) summary
    cl26863
    Location:23 → 194
    Sugar_tr; Sugar (and other) transporter

  2. NM_001328619.2 → NP_001315548.1  solute carrier family 2, facilitated glucose transporter member 5 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AL158048
    Consensus CDS
    CCDS99.1
    UniProtKB/Swiss-Prot
    P22732, Q14770, Q5T977, Q8IVB3
    UniProtKB/TrEMBL
    B4DXN5
    Conserved Domains (1) summary
    pfam00083
    Location:23 → 475
    Sugar_tr; Sugar (and other) transporter

  3. NM_001328620.2 → NP_001315549.1  solute carrier family 2, facilitated glucose transporter member 5 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction at the 5' end of a coding exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL158048
    UniProtKB/TrEMBL
    B4DG19, B4DXM7
    Conserved Domains (2) summary
    cd06174
    Location:28 → 416
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:22 → 431
    Sugar_tr; Sugar (and other) transporter

  4. NM_001328621.2 → NP_001315550.1  solute carrier family 2, facilitated glucose transporter member 5 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks three alternate coding exons compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL158048
    UniProtKB/TrEMBL
    B4DU31

  5. NM_003039.3 → NP_003030.1  solute carrier family 2, facilitated glucose transporter member 5 isoform 1

    See identical proteins and their annotated locations for NP_003030.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AL158048, CA309754, DC379829, M55531
    Consensus CDS
    CCDS99.1
    UniProtKB/Swiss-Prot
    P22732, Q14770, Q5T977, Q8IVB3
    UniProtKB/TrEMBL
    B4DXN5
    Related
    ENSP00000366641.4, ENST00000377424.9
    Conserved Domains (1) summary
    pfam00083
    Location:23 → 475
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    9035106..9094195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428615.1 → XP_047284571.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

    UniProtKB/Swiss-Prot
    P22732, Q14770, Q5T977, Q8IVB3

  2. XM_047428614.1 → XP_047284570.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

    UniProtKB/Swiss-Prot
    P22732, Q14770, Q5T977, Q8IVB3

  3. XM_047428606.1 → XP_047284562.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

    UniProtKB/Swiss-Prot
    P22732, Q14770, Q5T977, Q8IVB3

  4. XM_047428612.1 → XP_047284568.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

    UniProtKB/Swiss-Prot
    P22732, Q14770, Q5T977, Q8IVB3

  5. XM_047428602.1 → XP_047284558.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

    UniProtKB/Swiss-Prot
    P22732, Q14770, Q5T977, Q8IVB3

  6. XM_047428623.1 → XP_047284579.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X2

  7. XM_047428588.1 → XP_047284544.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

    UniProtKB/Swiss-Prot
    P22732, Q14770, Q5T977, Q8IVB3

  8. XM_047428594.1 → XP_047284550.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

    UniProtKB/Swiss-Prot
    P22732, Q14770, Q5T977, Q8IVB3

  9. XM_047428598.1 → XP_047284554.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

    UniProtKB/Swiss-Prot
    P22732, Q14770, Q5T977, Q8IVB3

  10. XM_047428591.1 → XP_047284547.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

    UniProtKB/Swiss-Prot
    P22732, Q14770, Q5T977, Q8IVB3

  11. XM_047428625.1 → XP_047284581.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X3

    UniProtKB/TrEMBL
    B4DT82

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    8568756..8627452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338404.1 → XP_054194379.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

    UniProtKB/Swiss-Prot
    P22732, Q14770, Q5T977, Q8IVB3

  2. XM_054338405.1 → XP_054194380.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

    UniProtKB/Swiss-Prot
    P22732, Q14770, Q5T977, Q8IVB3

  3. XM_054338403.1 → XP_054194378.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

    UniProtKB/Swiss-Prot
    P22732, Q14770, Q5T977, Q8IVB3

  4. XM_054338406.1 → XP_054194381.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X2

  5. XM_054338399.1 → XP_054194374.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

    UniProtKB/Swiss-Prot
    P22732, Q14770, Q5T977, Q8IVB3

  6. XM_054338401.1 → XP_054194376.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

    UniProtKB/Swiss-Prot
    P22732, Q14770, Q5T977, Q8IVB3

  7. XM_054338402.1 → XP_054194377.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

    UniProtKB/Swiss-Prot
    P22732, Q14770, Q5T977, Q8IVB3

  8. XM_054338400.1 → XP_054194375.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X1

    UniProtKB/Swiss-Prot
    P22732, Q14770, Q5T977, Q8IVB3

  9. XM_054338407.1 → XP_054194382.1  solute carrier family 2, facilitated glucose transporter member 5 isoform X3

    UniProtKB/TrEMBL
    B4DT82

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_024180.1: Suppressed sequence

    Description
    NR_024180.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22732.1 GenPept UniProtKB/Swiss-Prot:P22732

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