oprm1 opioid receptor, mu 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: oprm1provided by ZNC
Official Full Name: opioid receptor, mu 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-010125-1
See related: Ensembl:ENSDARG00000039434 AllianceGenome:ZFIN:ZDB-GENE-010125-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: or2; ZFOR2
Summary: Enables G protein-coupled enkephalin receptor activity and morphine receptor activity. Predicted to be involved in G protein-coupled opioid receptor signaling pathway; neuropeptide signaling pathway; and sensory perception of pain. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Is integral component of plasma membrane. Is expressed in several structures, including nervous system; notochord; otic vesicle; prechordal plate; and trunk. Orthologous to human OPRM1 (opioid receptor mu 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (23843614..23882977)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (23713164..23752527)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA miR-212/132 cluster is actively repressing the expression of mu opioid receptor (Oprm1) by targeting a sequence in the 3' UTR of its mRNA.
Title: μ Opioid Receptor Expression after Morphine Administration Is Regulated by miR-212/132 Cluster.
demonstrate that zfMOR exhibits a pharmacological profile similar to that of the mammalian MOR.
Title: Mu opioid receptor from the zebrafish exhibits functional characteristics as those of mammalian mu opioid receptor.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled enkephalin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled opioid receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G-protein alpha-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-endorphin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-endorphin receptor activity	IEA Inferred from Electronic Annotation more info
enables morphine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables morphine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled opioid receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled opioid receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to morphine	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of pain	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mu-type opioid receptor

Names: ZfMOR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131707.2 → NP_571782.2 mu-type opioid receptor

Status: VALIDATED

Source sequence(s)

CR352246

UniProtKB/TrEMBL

A0A8M1P6J5, B8JHS2

Related

ENSDARP00000057610.2, ENSDART00000057611.3

Conserved Domains (2) summary

pfam00001
Location:77 → 331

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:69 → 276

7tm_4; Olfactory receptor