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RBM15 RNA binding motif protein 15 [ Homo sapiens (human) ]

Gene ID: 64783, updated on 7-Apr-2024

Summary

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Official Symbol
RBM15provided by HGNC
Official Full Name
RNA binding motif protein 15provided by HGNC
Primary source
HGNC:HGNC:14959
See related
Ensembl:ENSG00000162775 MIM:606077; AllianceGenome:HGNC:14959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OTT; OTT1; SPEN
Summary
Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]
Expression
Broad expression in bone marrow (RPKM 6.3), testis (RPKM 2.8) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See RBM15 in Genome Data Viewer
Location:
1p13.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (110339377..110346677)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (110354432..110361733)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110881999..110889299)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily C member 4 Neighboring gene uncharacterized LOC124900436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1466 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:110837163-110837321 Neighboring gene RBM15 antisense RNA 1 Neighboring gene uncharacterized LOC124904276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1467 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1468 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:110882428-110883166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:110883828-110884393 Neighboring gene solute carrier family 16 member 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1471 Neighboring gene LAMTOR5 and SLC16A4 antisense RNA 1 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RBM15 silencing promotes ferroptosis by regulating the TGF-β/Smad2 pathway in lung cancer. Feng J, et al. Environ Toxicol, 2023 Mar. PMID 36715115
  2. The prognostic value of N6-methyladenosine RBM15 regulators in lung adenocarcinoma. Ma M, et al. Cell Mol Biol (Noisy-le-grand), 2022 May 22. PMID 35809319
  3. RBM15-mediated N6-methyladenosine modification affects COVID-19 severity by regulating the expression of multitarget genes. Meng Y, et al. Cell Death Dis, 2021 Jul 23. PMID 34301919, Free PMC Article
  4. Biological effects of decreasing RBM15 on chronic myelogenous leukemia cells. Yang Y, et al. Leuk Lymphoma, 2012 Nov. PMID 22497198
  5. Acute megakaryoblastic leukemia with a four-way variant translocation originating the RBM15-MKL1 fusion gene. Torres L, et al. Pediatr Blood Cancer, 2011 May. PMID 21370421

See all (119) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulatory mechanism of RNA binding motif protein 15-mediated N[6] methyladenosine modification in proliferation, invasion, and migration of colorectal cancer cells.
    Title: Regulatory mechanism of RNA binding motif protein 15-mediated N(6) methyladenosine modification in proliferation, invasion, and migration of colorectal cancer cells.
  2. RBM15-mediating MDR1 mRNA m[6]A methylation regulated by the TGF-beta signaling pathway in paclitaxel-resistant ovarian cancer.
    Title: RBM15‑mediating MDR1 mRNA m(6)A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer.
  3. RBM15 m[6] A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling.
    Title: RBM15 m(6) A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling.
  4. Knockdown of RBM15 inhibits tumor progression and the JAK-STAT signaling pathway in cervical cancer.
    Title: Knockdown of RBM15 inhibits tumor progression and the JAK-STAT signaling pathway in cervical cancer.
  5. RBM15 silencing promotes ferroptosis by regulating the TGF-beta/Smad2 pathway in lung cancer.
    Title: RBM15 silencing promotes ferroptosis by regulating the TGF-β/Smad2 pathway in lung cancer.
  6. Knockdown RBM15 Inhibits Colorectal Cancer Cell Proliferation and Metastasis Via N6-Methyladenosine (m6A) Modification of MyD88 mRNA.
    Title: Knockdown RBM15 Inhibits Colorectal Cancer Cell Proliferation and Metastasis Via N6-Methyladenosine (m6A) Modification of MyD88 mRNA.
  7. The prognostic value of N6-methyladenosine RBM15 regulators in lung adenocarcinoma.
    Title: The prognostic value of N6-methyladenosine RBM15 regulators in lung adenocarcinoma.
  8. Epigenetic activation of RBM15 promotes clear cell renal cell carcinoma growth, metastasis and macrophage infiltration by regulating the m6A modification of CXCL11.
    Title: Epigenetic activation of RBM15 promotes clear cell renal cell carcinoma growth, metastasis and macrophage infiltration by regulating the m6A modification of CXCL11.
  9. RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent.
    Title: RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent.
  10. RBM15-mediated N6-methyladenosine modification affects COVID-19 severity by regulating the expression of multitarget genes.
    Title: RBM15-mediated N6-methyladenosine modification affects COVID-19 severity by regulating the expression of multitarget genes.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag NXF1 upregulates the RBM15-mediated Gag expression from pNLgag-RTE, suggesting cooperation between RBM15 and NXF1 PubMed
Rev rev HIV-1 Rev interacting protein, RNA binding motif protein 15 (RBM15), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with RBM15 is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12479, FLJ21943, MGC119584

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in branching involved in blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in dosage compensation by inactivation of X chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of myeloid cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in placenta blood vessel development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription of Notch receptor target IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of megakaryocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spleen development IEA
Inferred from Electronic Annotation
more info
  
involved_in thrombopoietin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ventricular septum morphogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA N6-methyladenosine methyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding protein 15
Names
one twenty two protein
one twenty-two
one-twenty two protein 1
putative RNA-binding protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201545.2 → NP_001188474.1  RNA-binding protein 15 isoform 2

    See identical proteins and their annotated locations for NP_001188474.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AI863760, AL355488, BC006397, BC098140
    Consensus CDS
    CCDS59198.1
    UniProtKB/TrEMBL
    A0A499FJY3
    Related
    ENSP00000473552.3, ENST00000487146.8
    Conserved Domains (5) summary
    TIGR01622
    Location:624 → 736
    SF-CC1; splicing factor, CC1-like family
    pfam07744
    Location:781 → 954
    SPOC; SPOC domain
    cd12553
    Location:169 → 251
    RRM1_RBM15; RNA recognition motif 1 (RRM1) found in vertebrate RNA binding motif protein 15 (RBM15)
    cd12555
    Location:367 → 453
    RRM2_RBM15; RNA recognition motif 2 (RRM2) found in vertebrate RNA binding motif protein 15 (RBM15)
    cd12557
    Location:456 → 528
    RRM3_RBM15; RNA recognition motif 3 (RRM3) found in vertebrate RNA binding motif protein 15 (RBM15)

  2. NM_022768.5 → NP_073605.4  RNA-binding protein 15 isoform 1

    See identical proteins and their annotated locations for NP_073605.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AL355488, BC042587, BC047479, BC062316
    Consensus CDS
    CCDS822.1
    UniProtKB/Swiss-Prot
    A1A693, Q3ZB86, Q4V760, Q5D058, Q5T613, Q86VW9, Q96PE4, Q96SC9, Q96SD0, Q96T37, Q96T38, Q9BRA5, Q9H6R8, Q9H9Y0
    UniProtKB/TrEMBL
    A0A087WWP4
    Related
    ENSP00000358799.3, ENST00000369784.9
    Conserved Domains (5) summary
    TIGR01622
    Location:624 → 736
    SF-CC1; splicing factor, CC1-like family
    pfam07744
    Location:781 → 954
    SPOC; SPOC domain
    cd12553
    Location:169 → 251
    RRM1_RBM15; RNA recognition motif 1 (RRM1) found in vertebrate RNA binding motif protein 15 (RBM15)
    cd12555
    Location:367 → 453
    RRM2_RBM15; RNA recognition motif 2 (RRM2) found in vertebrate RNA binding motif protein 15 (RBM15)
    cd12557
    Location:456 → 528
    RRM3_RBM15; RNA recognition motif 3 (RRM3) found in vertebrate RNA binding motif protein 15 (RBM15)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    110339377..110346677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    110354432..110361733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014092.1: Suppressed sequence

    Description
    NM_014092.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96T37.2 GenPept UniProtKB/Swiss-Prot:Q96T37

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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