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Slc5a4b solute carrier family 5 (neutral amino acid transporters, system A), member 4b [ Mus musculus (house mouse) ]

Gene ID: 64454, updated on 11-Apr-2024

Summary

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Official Symbol
Slc5a4bprovided by MGI
Official Full Name
solute carrier family 5 (neutral amino acid transporters, system A), member 4bprovided by MGI
Primary source
MGI:MGI:1890478
See related
Ensembl:ENSMUSG00000020226 AllianceGenome:MGI:1890478
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SAAT1; SGLT3b; pSGLT2; SGLT3-b; 2010104G07Rik
Summary
Enables carbohydrate:cation symporter activity. Acts upstream of or within glucose transmembrane transport and sodium ion transport. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Orthologous to human SLC5A4 (solute carrier family 5 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 17.7), small intestine adult (RPKM 14.0) and 3 other tissues See more
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Genomic context

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Location:
10 C1; 10 38.68 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75894452..75946852, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (76058618..76111018, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5134 Neighboring gene STARR-positive B cell enhancer ABC_E8345 Neighboring gene STARR-seq mESC enhancer starr_27168 Neighboring gene microRNA 6409 Neighboring gene STARR-seq mESC enhancer starr_27169 Neighboring gene STARR-positive B cell enhancer ABC_E3892 Neighboring gene STARR-seq mESC enhancer starr_27170 Neighboring gene STARR-seq mESC enhancer starr_27172 Neighboring gene zinc finger protein 280B Neighboring gene predicted gene 16222 Neighboring gene STARR-seq mESC enhancer starr_27174 Neighboring gene solute carrier family 5 (neutral amino acid transporters, system A), member 4b pseudogene Neighboring gene solute carrier family 5, member 4a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sodium-glucose transporter type 3-mediated neuroprotective effect of acetylcholine suppresses the development of cerebral ischemic neuronal damage. Yamazaki Y, et al. Neuroscience, 2014 Jun 6. PMID 24699226
  2. Sugar binding residue affects apparent Na+ affinity and transport stoichiometry in mouse sodium/glucose cotransporter type 3B. Díez-Sampedro A, et al. J Biol Chem, 2011 Mar 11. PMID 21187287, Free PMC Article
  3. Functional characterization of mouse sodium/glucose transporter type 3b. Aljure O, et al. Am J Physiol Cell Physiol, 2010 Jul. PMID 20392930
  4. Mouse kidney expresses mRNA of four highly related sodium-glucose cotransporters: regulation by cadmium. Tabatabai NM, et al. Kidney Int, 2003 Oct. PMID 12969150
  5. Mouse SGLT3a generates proton-activated currents but does not transport sugar. Barcelona S, et al. Am J Physiol Cell Physiol, 2012 Apr 15. PMID 22301059

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest that activation of SGLT-3 in post-ischemic hyperglycemia may suppress the development of cerebral ischemic neuronal damage by releasing acetylcholine via its activation of cholinergic neurons
    Title: Sodium-glucose transporter type 3-mediated neuroprotective effect of acetylcholine suppresses the development of cerebral ischemic neuronal damage.
  2. Sugar binding residue affects apparent Na+ affinity and transport stoichiometry in mouse sodium/glucose cotransporter type 3B.
    Title: Sugar binding residue affects apparent Na+ affinity and transport stoichiometry in mouse sodium/glucose cotransporter type 3B.
  3. Low sugar affinity and uncoupled sugar transport lead us to conclude that mSGLT3b likely functions as a physiological glucose sensor similar to hSGLT3.
    Title: Functional characterization of mouse sodium/glucose transporter type 3b.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate:monoatomic cation symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucose:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables low-affinity glucose:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within carbohydrate transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within glucose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within monoatomic cation transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sodium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IC
Inferred by Curator
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
solute carrier family 5 member 4B
Names
low affinity sodium-glucose cotransporter
solute carrier family 5 member 4b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023219.2 → NP_075708.2  solute carrier family 5 member 4B

    See identical proteins and their annotated locations for NP_075708.2

    Status: VALIDATED

    Source sequence(s)
    AC140851, AV259402, BC109133
    Consensus CDS
    CCDS48603.1
    UniProtKB/Swiss-Prot
    Q91ZP4, Q9ET36
    UniProtKB/TrEMBL
    Q3UNC8
    Related
    ENSMUSP00000113582.2, ENSMUST00000120757.2
    Conserved Domains (1) summary
    cl00456
    Location:27 → 660
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    75894452..75946852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243522.1 → XP_011241824.1  solute carrier family 5 member 4B isoform X2

    Conserved Domains (1) summary
    cl00456
    Location:13 → 511
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. XM_017314051.1 → XP_017169540.1  solute carrier family 5 member 4B isoform X3

    Conserved Domains (1) summary
    cl00456
    Location:1 → 450
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. XM_006513945.2 → XP_006514008.1  solute carrier family 5 member 4B isoform X1

    Conserved Domains (1) summary
    cl00456
    Location:22 → 520
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZP4.2 GenPept UniProtKB/Swiss-Prot:Q91ZP4

Gene LinkOut

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