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ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [ Homo sapiens (human) ]

Gene ID: 64411, updated on 3-Apr-2024

Summary

Official Symbol
ARAP3provided by HGNC
Official Full Name
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3provided by HGNC
Primary source
HGNC:HGNC:24097
See related
Ensembl:ENSG00000120318 MIM:606647; AllianceGenome:HGNC:24097
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRAG1; CENTD3
Summary
This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Sep 2015]
Expression
Broad expression in lung (RPKM 9.2), fat (RPKM 7.9) and 24 other tissues See more
Orthologs
NEW
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Genomic context

Location:
5q31.3
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (141653402..141682230, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (142179417..142208259, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (141032969..141061797, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23309 Neighboring gene histone deacetylase 3 Neighboring gene Sharpr-MPRA regulatory region 64 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16457 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23311 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141029007-141029585 Neighboring gene RELT like 2 Neighboring gene FCH and double SH3 domains 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:141037429-141038628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16459 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:141053759-141054426 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:141054427-141055095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141071853-141072386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141072387-141072920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141080718-141081218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23312 Neighboring gene uncharacterized LOC124901092 Neighboring gene uncharacterized LOC124901093 Neighboring gene Sharpr-MPRA regulatory region 9303 Neighboring gene Sharpr-MPRA regulatory region 9103 Neighboring gene uncharacterized LOC124901094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141137138-141137707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141137708-141138276 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141138277-141138846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141141594-141142094

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ21065

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-3,4-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle-mediated transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in ruffle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
Names
ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein 3
Arf and Rho GAP adapter protein 3
PtdIns(3,4,5)P3-binding protein
centaurin-delta-3
phosphoinositide binding protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046966.1 RefSeqGene

    Range
    5004..33832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022481.6NP_071926.4  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

    See identical proteins and their annotated locations for NP_071926.4

    Status: REVIEWED

    Source sequence(s)
    AJ310567, AK024718, BC025757, BX489939
    Consensus CDS
    CCDS4266.1
    UniProtKB/Swiss-Prot
    B4DIT1, D3DQE3, Q8WWN8
    UniProtKB/TrEMBL
    A8K1Y7
    Related
    ENSP00000239440.4, ENST00000239440.9
    Conserved Domains (11) summary
    cd09490
    Location:466
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    smart00454
    Location:1264
    SAM; Sterile alpha motif
    cd04385
    Location:9091084
    RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
    cd13253
    Location:289381
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:398479
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13256
    Location:676786
    PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
    cd13259
    Location:12121331
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    pfam00169
    Location:288379
    PH; PH domain
    pfam00788
    Location:11171209
    RA; Ras association (RalGDS/AF-6) domain
    pfam01412
    Location:490606
    ArfGap; Putative GTPase activating protein for Arf
    cl17171
    Location:846894
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    141653402..141682230 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417514.1XP_047273470.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X12

  2. XM_047417513.1XP_047273469.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X11

    Related
    ENSP00000421826.1, ENST00000508305.5
  3. XM_047417512.1XP_047273468.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X10

  4. XM_047417511.1XP_047273467.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X9

  5. XM_047417510.1XP_047273466.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X8

  6. XM_005268499.2XP_005268556.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X6

    UniProtKB/TrEMBL
    A8K1Y7
    Conserved Domains (8) summary
    cd04385
    Location:8311006
    RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
    cd13253
    Location:211303
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:320401
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13256
    Location:598708
    PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
    pfam00169
    Location:210301
    PH; PH domain
    pfam00788
    Location:10391131
    RA; Ras association (RalGDS/AF-6) domain
    pfam01412
    Location:412528
    ArfGap; Putative GTPase activating protein for Arf
    cl17171
    Location:11341253
    PH-like; Pleckstrin homology-like domain
  7. XM_047417509.1XP_047273465.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X7

  8. XM_047417508.1XP_047273464.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X5

  9. XM_047417507.1XP_047273463.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X4

  10. XM_005268498.3XP_005268555.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X3

    UniProtKB/TrEMBL
    A8K1Y7
    Conserved Domains (11) summary
    cd09490
    Location:466
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    smart00454
    Location:1264
    SAM; Sterile alpha motif
    cd04385
    Location:9091064
    RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
    cd13253
    Location:289381
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:398479
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13256
    Location:676786
    PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
    cd13259
    Location:11921311
    PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
    pfam00169
    Location:288379
    PH; PH domain
    pfam00788
    Location:10971189
    RA; Ras association (RalGDS/AF-6) domain
    pfam01412
    Location:490606
    ArfGap; Putative GTPase activating protein for Arf
    cl17171
    Location:846894
    PH-like; Pleckstrin homology-like domain
  11. XM_047417506.1XP_047273462.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X2

  12. XM_047417505.1XP_047273461.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    B4DIT1, D3DQE3, Q8WWN8
  13. XM_011537677.3XP_011535979.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X13

    UniProtKB/TrEMBL
    A8K1Y7
    Related
    ENSP00000421468.1, ENST00000513878.5
    Conserved Domains (8) summary
    cd04385
    Location:714889
    RhoGAP_ARAP; RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ...
    cd13253
    Location:94186
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:203284
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13256
    Location:481591
    PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
    pfam00169
    Location:93184
    PH; PH domain
    pfam00788
    Location:9221014
    RA; Ras association (RalGDS/AF-6) domain
    pfam01412
    Location:295411
    ArfGap; Putative GTPase activating protein for Arf
    cl17171
    Location:10171136
    PH-like; Pleckstrin homology-like domain
  14. XM_005268500.5XP_005268557.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X14

    Conserved Domains (9) summary
    cd09490
    Location:466
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    smart00454
    Location:1264
    SAM; Sterile alpha motif
    cd13253
    Location:289381
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:398479
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd13256
    Location:676786
    PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
    pfam00169
    Location:288379
    PH; PH domain
    pfam01412
    Location:490606
    ArfGap; Putative GTPase activating protein for Arf
    cl02570
    Location:909934
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl17171
    Location:846894
    PH-like; Pleckstrin homology-like domain
  15. XM_047417515.1XP_047273471.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X15

RNA

  1. XR_007058626.1 RNA Sequence

  2. XR_007058625.1 RNA Sequence

  3. XR_007058624.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    142179417..142208259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353120.1XP_054209095.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X12

  2. XM_054353119.1XP_054209094.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X11

  3. XM_054353118.1XP_054209093.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X10

  4. XM_054353117.1XP_054209092.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X9

  5. XM_054353116.1XP_054209091.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X8

  6. XM_054353114.1XP_054209089.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X6

  7. XM_054353112.1XP_054209087.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X4

  8. XM_054353115.1XP_054209090.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X7

  9. XM_054353110.1XP_054209085.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X2

  10. XM_054353111.1XP_054209086.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X3

  11. XM_054353113.1XP_054209088.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X5

  12. XM_054353121.1XP_054209096.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X13

  13. XM_054353122.1XP_054209097.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X14

  14. XM_054353123.1XP_054209098.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X15

RNA

  1. XR_008487146.1 RNA Sequence

  2. XR_008487145.1 RNA Sequence

  3. XR_008487144.1 RNA Sequence