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Arf1 ADP-ribosylation factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64310, updated on 13-Apr-2024

Summary

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Official Symbol
Arf1provided by RGD
Official Full Name
ADP-ribosylation factor 1provided by RGD
Primary source
RGD:621270
See related
Ensembl:ENSRNOG00000060229 AllianceGenome:RGD:621270
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables guanyl ribonucleotide binding activity; magnesium ion binding activity; and phospholipase D activator activity. Involved in several processes, including Golgi to transport vesicle transport; positive regulation of transport; and postsynapse organization. Located in cytosol and late endosome. Is active in glutamatergic synapse and postsynaptic density. Colocalizes with COPI-coated vesicle; Golgi apparatus; and peroxisomal membrane. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARF1 (ADP ribosylation factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 1161.3), Heart (RPKM 1073.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arf1 in Genome Data Viewer
Location:
10q22
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (44497543..44513994, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (43997983..44014461, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (45562700..45579214, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene guanylate kinase 1 Neighboring gene similar to human chromosome 1 open reading frame 35 Neighboring gene mitochondrial ribosomal protein L55 Neighboring gene Wnt family member 3A Neighboring gene Wnt family member 9A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Role of Arf1 in endosomal trafficking of protein-metal complexes and cadmium-metallothionein-1 toxicity in kidney proximal tubule cells. Wolff NA, et al. Toxicol Lett, 2011 Jun 24. PMID 21421027
  2. Active ADP-ribosylation factor-1 (ARF1) is required for mitotic Golgi fragmentation. Xiang Y, et al. J Biol Chem, 2007 Jul 27. PMID 17562717, Free PMC Article
  3. The role of ARF1 and rab GTPases in polarization of the Golgi stack. Bannykh SI, et al. Traffic, 2005 Sep. PMID 16101683
  4. Role of ADP ribosylation factor 1 in the assembly and secretion of ApoB-100-containing lipoproteins. Asp L, et al. Arterioscler Thromb Vasc Biol, 2005 Mar. PMID 15618550
  5. Arf-1 (ADP-ribosylation factor-1) is involved in the activation of a mammalian Na+-selective current. Straube S, et al. Biochem J, 2004 Jan 15. PMID 14563210, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arf1 is a critical regulator of actin dynamics and synaptic function via modulation of PICK1.
    Title: The small GTPase Arf1 modulates Arp2/3-mediated actin polymerization via PICK1 to regulate synaptic plasticity.
  2. ARF1-dependent trafficking of procathepsin B and the maturation of autophagosomes results in cathepsin B-mediated trypsinogen activation induced by caerulein.
    Title: ADP-ribosylation factor 1 protein regulates trypsinogen activation via organellar trafficking of procathepsin B protein and autophagic maturation in acute pancreatitis.
  3. Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism
    Title: Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism.
  4. Arf1-GTP-induced tubule formation suggests a function of Arf family proteins in curvature acquisition at sites of vesicle budding.
    Title: Arf1-GTP-induced tubule formation suggests a function of Arf family proteins in curvature acquisition at sites of vesicle budding.
  5. p24A is a regulator of signal-dependent trafficking that controls ARF1-dependent resensitization of PAR-2
    Title: p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking.
  6. ARF1 is active during mitosis and this activity is required for mitotic Golgi fragmentation.
    Title: Active ADP-ribosylation factor-1 (ARF1) is required for mitotic Golgi fragmentation.
  7. Activation of a non-voltage-activated Na(+)-selective current requires Arf1.
    Title: Arf-1 (ADP-ribosylation factor-1) is involved in the activation of a mammalian Na+-selective current.
  8. Arf GTPases are expressed and targeted in a cell- and membrane-specific pattern in kidney epithelial cells in situ.
    Title: Differential expression and targeting of endogenous Arf1 and Arf6 small GTPases in kidney epithelial cells in situ.
  9. ARF1 and ARF6 are both found on peroxisomes, but coatomer recruitment only depends on ARF1-GTP
    Title: Binding and functions of ADP-ribosylation factor on mammalian and yeast peroxisomes.
  10. Overexpression of ARF1 increased the assembly of VLDL 2 but not of VLDL 1, whose production was dependent on both anterograde transport and the availability of fatty acids.
    Title: Role of ADP ribosylation factor 1 in the assembly and secretion of ApoB-100-containing lipoproteins.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC72830

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GDP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase D activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi to transport vesicle transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendritic spine organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular copper ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-term synaptic depression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lysosomal membrane organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic cleavage furrow ingression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ER to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of calcium ion-dependent exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of dendritic spine development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of late endosome to lysosome transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of sodium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postsynaptic actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynaptic actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of phospholipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of receptor internalization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle budding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in very-low-density lipoprotein particle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in COPI-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endomembrane system ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ADP-ribosylation factor 1
NP_001400966.1
NP_001400967.1
NP_071963.1
XP_063125885.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414037.1 → NP_001400966.1  ADP-ribosylation factor 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P84079
    UniProtKB/TrEMBL
    A6HEZ7

  2. NM_001414038.1 → NP_001400967.1  ADP-ribosylation factor 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P84079
    UniProtKB/TrEMBL
    A6HEZ7
    Related
    ENSRNOP00000072575.1, ENSRNOT00000080028.2

  3. NM_022518.5 → NP_071963.1  ADP-ribosylation factor 1

    See identical proteins and their annotated locations for NP_071963.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P84079
    UniProtKB/TrEMBL
    A0A8I5ZKF2, A6HEZ7
    Conserved Domains (1) summary
    smart00177
    Location:5 → 179
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    44497543..44513994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269815.1 → XP_063125885.1  ADP-ribosylation factor 1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P84079.2 GenPept UniProtKB/Swiss-Prot:P84079

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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