Foxb1 forkhead box B1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Foxb1provided by MGI
Official Full Name: forkhead box B1provided by MGI
Primary source: MGI:MGI:1927549
See related: Ensembl:ENSMUSG00000059246 AllianceGenome:MGI:1927549
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C43; Mf3; Twh; Fkh5; Foxb1a; Foxb1b; Hfh-e5.1
Summary: Enables sequence-specific DNA binding activity. Involved in several processes, including mammary gland development; nervous system development; and visual learning. Acts upstream of or within spinal cord development; thalamus development; and urogenital system development. Located in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; limb; paraxial mesenchyme; and tail bud. Orthologous to human FOXB1 (forkhead box B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in whole brain E14.5 (RPKM 3.7), CNS E14 (RPKM 2.6) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 D; 9 38.76 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (69664992..69668222, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (69757710..69760940, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here we study migrations in the hypothalamic primordium by genetically labeling the Foxb1 diencephalic lineage.
Title: Genetic mapping of Foxb1-cell lineage shows migration from caudal diencephalon to telencephalon and lateral hypothalamus.
Foxb1 mutants showed deficits in the task for spatial navigation within the Barnes maze. Furthermore, they showed impairments in spatial working memory tasks such as the spontaneous alternation and the working memory test in the radial arm maze.
Title: Genetic ablation of the mammillary bodies in the Foxb1 mutant mouse leads to selective deficit of spatial working memory.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:489236 (e-PCR)
- UniSTS:489236

AU047864 (e-PCR)
- UniSTS:110101

Foxb1 (e-PCR), detects polymorphism
- UniSTS:143130

Foxb1 (e-PCR), detects polymorphism
- UniSTS:547221

X92592 (e-PCR)
- UniSTS:125889

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon target recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration in diencephalon	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell differentiation involved in mammary gland alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in floor plate development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hypothalamus cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inferior colliculus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lactation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mammary gland lobule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mammillary body development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mammillary body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mammillothalamic axonal tract development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spinal cord development	IEP Inferred from Expression Pattern more info	PubMed
involved_in telencephalon cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thalamus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in urogenital system development	IEP Inferred from Expression Pattern more info	PubMed
involved_in visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: forkhead box protein B1

Names: forkhead box B1a; forkhead box B1b; mesoderm/mesenchyme forkhead 3; transcription factor FKH-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.