star steroidogenic acute regulatory protein [Danio rerio (zebrafish)] - Gene

Summary

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Official Symbol: starprovided by ZNC
Official Full Name: steroidogenic acute regulatory proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-001120-3
See related: Ensembl:ENSDARG00000006137 AllianceGenome:ZFIN:ZDB-GENE-001120-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable cholesterol binding activity. Acts upstream of or within oocyte maturation. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial intermembrane space. Is expressed in endocrine system; forebrain; gonad; and interrenal primordium. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to human STAR (steroidogenic acute regulatory protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (44703856..44707937)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (44709950..44714031)

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Steroidogenic acute regulatory protein and luteinizing hormone are required for normal ovarian steroidogenesis and oocyte maturation in zebrafishdagger.
Title: Steroidogenic acute regulatory protein and luteinizing hormone are required for normal ovarian steroidogenesis and oocyte maturation in zebrafish†.
Results suggest that gonadotropins play a key role in the regulation of StAR, 17beta-HSD3, and P450aromA in zebrafish.
Title: Characterization of the mRNA expression of StAR and steroidogenic enzymes in zebrafish ovarian follicles.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cholesterol binding	IBA Inferred from Biological aspect of Ancestor more info
enables cholesterol binding	IEA Inferred from Electronic Annotation more info
enables cholesterol transfer activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular cholesterol transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of steroid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within steroid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: steroidogenic acute regulatory protein, mitochondrial

Names: START domain-containing protein 1; stARD1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131663.1 → NP_571738.1 steroidogenic acute regulatory protein, mitochondrial precursor

See identical proteins and their annotated locations for NP_571738.1

Status: PROVISIONAL

Source sequence(s)

AF220435

UniProtKB/Swiss-Prot

Q9DG10

Related

ENSDARP00000023907.6, ENSDART00000016225.7

Conserved Domains (1) summary

cd08905
Location:68 → 275

START_STARD1-like; Cholesterol-binding START domain of mammalian STARD1 and related proteins