ARHGEF10 Rho guanine nucleotide exchange factor 10 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: ARHGEF10provided by VGNC
Official Full Name: Rho guanine nucleotide exchange factor 10provided by VGNC
Primary source: VGNC:VGNC:38072
See related: Ensembl:ENSCAFG00845025529
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	16	NC_051820.1 (61881132..61970321, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	16	NC_006598.4 (49689515..49778687)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	16	NC_049237.1 (60173735..60263094, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	16	NC_049276.1 (54329445..54418473)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	16	NC_049757.1 (59789595..59878802, complement)

Chromosome 16 - NC_051820.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An ARHGEF10 deletion is highly associated with a juvenile-onset inherited polyneuropathy in Leonberger and Saint Bernard dogs.
Title: An ARHGEF10 deletion is highly associated with a juvenile-onset inherited polyneuropathy in Leonberger and Saint Bernard dogs.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in mitotic spindle assembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: rho guanine nucleotide exchange factor 10; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 10

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051820.1 Reference ROS_Cfam_1.0

Range

61881132..61970321 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038690380.1 → XP_038546308.1 rho guanine nucleotide exchange factor 10 isoform X3

UniProtKB/TrEMBL

A0A8I3S5G3

Related

ENSCAFP00845035337.1, ENSCAFT00845045076.1

Conserved Domains (3) summary

cd00160
Location:355 → 539

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:819 → 1289

WD40_2; WD40 repeated domain

pfam19057
Location:562 → 711

PH_19; PH domain
XM_038690379.1 → XP_038546307.1 rho guanine nucleotide exchange factor 10 isoform X2

UniProtKB/TrEMBL

A0A8I3S5G3

Conserved Domains (3) summary

cd00160
Location:394 → 577

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:857 → 1327

WD40_2; WD40 repeated domain

pfam19057
Location:600 → 749

PH_19; PH domain
XM_038690377.1 → XP_038546305.1 rho guanine nucleotide exchange factor 10 isoform X1

UniProtKB/TrEMBL

A0A8I3S5G3

Related

ENSCAFP00845035770.1, ENSCAFT00845045597.1

Conserved Domains (3) summary

cd00160
Location:394 → 578

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:858 → 1328

WD40_2; WD40 repeated domain

pfam19057
Location:601 → 750

PH_19; PH domain
XM_038690378.1 → XP_038546306.1 rho guanine nucleotide exchange factor 10 isoform X1

UniProtKB/TrEMBL

A0A8I3S5G3

Conserved Domains (3) summary

cd00160
Location:394 → 578

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:858 → 1328

WD40_2; WD40 repeated domain

pfam19057
Location:601 → 750

PH_19; PH domain

Alternate UMICH_Zoey_3.1

Genomic

NC_049276.1 Alternate UMICH_Zoey_3.1

Range

54329445..54418473

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038498040.1 → XP_038353968.1 LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 10 isoform X1

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049757.1 Alternate UNSW_CanFamBas_1.0

Range

59789595..59878802 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038624593.1 → XP_038480521.1 rho guanine nucleotide exchange factor 10 isoform X3
XM_038624592.1 → XP_038480520.1 rho guanine nucleotide exchange factor 10 isoform X2
XM_038624590.1 → XP_038480518.1 rho guanine nucleotide exchange factor 10 isoform X1
XM_038624591.1 → XP_038480519.1 rho guanine nucleotide exchange factor 10 isoform X1

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049237.1 Alternate UU_Cfam_GSD_1.0

Range

60173735..60263094 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038560553.1 → XP_038416481.1 rho guanine nucleotide exchange factor 10 isoform X3

UniProtKB/TrEMBL

A0A8I3S5G3
XM_038560552.1 → XP_038416480.1 rho guanine nucleotide exchange factor 10 isoform X2

UniProtKB/TrEMBL

A0A8I3S5G3
XM_038560549.1 → XP_038416477.1 rho guanine nucleotide exchange factor 10 isoform X1

UniProtKB/TrEMBL

A0A8I3S5G3
XM_038560551.1 → XP_038416479.1 rho guanine nucleotide exchange factor 10 isoform X1

UniProtKB/TrEMBL

A0A8I3S5G3

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006598.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

49689515..49778687

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038452317.1 → XP_038308245.1 rho guanine nucleotide exchange factor 10 isoform X1

UniProtKB/TrEMBL

A0A8I3S5G3, A0A8P0TPS0

Conserved Domains (3) summary

cd00160
Location:394 → 578

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:858 → 1328

WD40_2; WD40 repeated domain

pfam19057
Location:601 → 750

PH_19; PH domain
XM_038452319.1 → XP_038308247.1 rho guanine nucleotide exchange factor 10 isoform X2

UniProtKB/TrEMBL

A0A8I3S5G3

Conserved Domains (3) summary

cd00160
Location:394 → 577

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:857 → 1327

WD40_2; WD40 repeated domain

pfam19057
Location:600 → 749

PH_19; PH domain
XM_038452321.1 → XP_038308249.1 rho guanine nucleotide exchange factor 10 isoform X3

UniProtKB/TrEMBL

A0A8I3S5G3, A0A8P0TJQ1

Conserved Domains (3) summary

cd00160
Location:355 → 539

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:819 → 1289

WD40_2; WD40 repeated domain

pfam19057
Location:562 → 711

PH_19; PH domain
XM_038452318.1 → XP_038308246.1 rho guanine nucleotide exchange factor 10 isoform X1

UniProtKB/TrEMBL

A0A8I3S5G3, A0A8P0TPS0

Conserved Domains (3) summary

cd00160
Location:394 → 578

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:858 → 1328

WD40_2; WD40 repeated domain

pfam19057
Location:601 → 750

PH_19; PH domain