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Capn12 calpain 12 [ Mus musculus (house mouse) ]

Gene ID: 60594, updated on 30-Apr-2024

Summary

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Official Symbol
Capn12provided by MGI
Official Full Name
calpain 12provided by MGI
Primary source
MGI:MGI:1891369
See related
Ensembl:ENSMUSG00000054083 AllianceGenome:MGI:1891369
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CANP 12
Summary
Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Orthologous to human CAPN12 (calpain 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 12.1), stomach adult (RPKM 9.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B1; 7 16.94 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28580890..28593010)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28881465..28893585)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29650992-29651179 Neighboring gene lectin, galactose binding, soluble 7 Neighboring gene predicted gene 10648 Neighboring gene predicted gene 44700 Neighboring gene actinin alpha 4 Neighboring gene STARR-seq mESC enhancer starr_18442 Neighboring gene predicted gene, 38978 Neighboring gene STARR-seq mESC enhancer starr_18446 Neighboring gene predicted gene, 51446

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of the placental iron exporter ferroportin 1 causes embryonic demise in late-gestation mouse pregnancy. Cao C, et al. Development, 2022 Dec 1. PMID 36398730
  2. Gene structure, chromosomal localization, and expression pattern of Capn12, a new member of the calpain large subunit gene family. Dear TN, et al. Genomics, 2000 Sep 1. PMID 10964513
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
calpain-12
Names
calcium-activated neutral proteinase 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110807.1 → NP_001104277.1  calpain-12

    Status: VALIDATED

    Source sequence(s)
    AC166357, AC171210
    Consensus CDS
    CCDS52166.1
    UniProtKB/Swiss-Prot
    Q9ER53, Q9ER54, Q9ER55, Q9ER56
    UniProtKB/TrEMBL
    E9QL26
    Related
    ENSMUSP00000069055.5, ENSMUST00000066880.6
    Conserved Domains (2) summary
    cd00214
    Location:352 → 531
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    pfam00648
    Location:46 → 339
    Peptidase_C2; Calpain family cysteine protease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28580890..28593010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004934158.1 RNA Sequence

  2. XR_003946533.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_021894.1: Suppressed sequence

    Description
    NM_021894.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ER56.1 GenPept UniProtKB/Swiss-Prot:Q9ER56

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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