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TRMT11 tRNA methyltransferase 11 homolog [ Homo sapiens (human) ]

Gene ID: 60487, updated on 11-Apr-2024

Summary

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Official Symbol
TRMT11provided by HGNC
Official Full Name
tRNA methyltransferase 11 homologprovided by HGNC
Primary source
HGNC:HGNC:21080
See related
Ensembl:ENSG00000066651 AllianceGenome:HGNC:21080
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRM11; MDS024; C6orf75; TRMT11-1
Summary
Predicted to enable tRNA (guanine-N2-)-methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in endometrium (RPKM 2.2), duodenum (RPKM 1.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
6q22.32
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (125986540..126272343)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (127175155..127468301)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (126307686..126400874)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 7 Neighboring gene uncharacterized LOC124901397 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:126239365-126240564 Neighboring gene NCOA7-HINT3 intergenic CAGE-defined high expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25032 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25033 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:126306909-126307739 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:126307740-126308569 Neighboring gene RNA, 5S ribosomal pseudogene 216 Neighboring gene histidine triad nucleotide binding protein 3 Neighboring gene Sharpr-MPRA regulatory region 12057 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25035 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25036 Neighboring gene centromere protein W Neighboring gene microRNA 588

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Germline predictors of androgen deprivation therapy response in advanced prostate cancer. Kohli M, et al. Mayo Clin Proc, 2012 Mar. PMID 22386179, Free PMC Article
  2. Human TRMT112-Methyltransferase Network Consists of Seven Partners Interacting with a Common Co-Factor. Brūmele B, et al. Int J Mol Sci, 2021 Dec 18. PMID 34948388, Free PMC Article
  3. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Elks CE, et al. Nat Genet, 2010 Dec. PMID 21102462, Free PMC Article
  4. A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network. Lunardi A, et al. Proc Natl Acad Sci U S A, 2010 Apr 6. PMID 20308539, Free PMC Article
  5. SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors. Jo U, et al. Proc Natl Acad Sci U S A, 2021 Feb 9. PMID 33536335, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SNPs associated with androgen deprivation failure in advanced prostate cancer
    Title: Germline predictors of androgen deprivation therapy response in advanced prostate cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tRNA (guanine(10)-N2)-methyltransferase homolog
Names
tRNA guanosine-2'-O-methyltransferase TRM11 homolog
NP_001026882.2
NP_001337509.1
NP_001337510.1
NP_001337511.1
NP_001337512.1
NP_001337513.1
NP_001337514.1
NP_001337515.1
NP_001337516.1
NP_001337517.1
NP_001337518.1
NP_001337519.1
NP_001337520.1
NP_001337521.1
NP_001337522.1
NP_001337523.1
NP_001337524.1
NP_001337525.1
NP_001337526.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031712.3 → NP_001026882.2  tRNA (guanine(10)-N2)-methyltransferase homolog isoform a

    See identical proteins and their annotated locations for NP_001026882.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AF532977, BC056878
    Consensus CDS
    CCDS35496.1
    UniProtKB/Swiss-Prot
    E1P570, Q5JY11, Q6PGQ5, Q7Z4G4, Q9HC13
    Related
    ENSP00000333934.5, ENST00000334379.11
    Conserved Domains (2) summary
    COG1041
    Location:9 → 416
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    cl17173
    Location:190 → 321
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. NM_001350580.2 → NP_001337509.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform b

    Status: VALIDATED

    Source sequence(s)
    AL035689
    Conserved Domains (1) summary
    cl28094
    Location:9 → 404
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  3. NM_001350581.2 → NP_001337510.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 4-6, encodes isoform c.
    Source sequence(s)
    AL035689
    Conserved Domains (1) summary
    cl28094
    Location:7 → 353
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  4. NM_001350582.2 → NP_001337511.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 3, 5, and 6, encodes isoform c.
    Source sequence(s)
    AL035689
    Conserved Domains (1) summary
    cl28094
    Location:7 → 353
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  5. NM_001350583.2 → NP_001337512.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 3, 4, and 6, encodes isoform c.
    Source sequence(s)
    AL035689
    Conserved Domains (1) summary
    cl28094
    Location:7 → 353
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  6. NM_001350584.2 → NP_001337513.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 3-5, encodes isoform c.
    Source sequence(s)
    AL035689
    Conserved Domains (1) summary
    cl28094
    Location:7 → 353
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  7. NM_001350585.2 → NP_001337514.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform d

    Status: VALIDATED

    Source sequence(s)
    AL035689
    Conserved Domains (1) summary
    COG1041
    Location:1 → 218
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  8. NM_001350586.2 → NP_001337515.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 9-19, encodes isoform e.
    Source sequence(s)
    AL035689
    Conserved Domains (1) summary
    cl28094
    Location:35 → 183
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  9. NM_001350587.2 → NP_001337516.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 8 and 10-19, encodes isoform e.
    Source sequence(s)
    AL035689
    Conserved Domains (1) summary
    cl28094
    Location:35 → 183
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  10. NM_001350588.2 → NP_001337517.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 8, 9, and 11-19, encodes isoform e.
    Source sequence(s)
    AL035689
    Conserved Domains (1) summary
    cl28094
    Location:35 → 183
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  11. NM_001350589.2 → NP_001337518.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 8-10 and 12-19, encodes isoform e.
    Source sequence(s)
    AL035689
    Conserved Domains (1) summary
    cl28094
    Location:35 → 183
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  12. NM_001350590.2 → NP_001337519.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 8-11 and 13-19, encodes isoform e.
    Source sequence(s)
    AL035689
    Conserved Domains (1) summary
    cl28094
    Location:35 → 183
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  13. NM_001350591.2 → NP_001337520.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 8-12 and 14-19, encodes isoform e.
    Source sequence(s)
    AL035689
    Conserved Domains (1) summary
    cl28094
    Location:35 → 183
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  14. NM_001350592.2 → NP_001337521.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variants 8-13 and 15-19, encodes isoform e.
    Source sequence(s)
    AL035689
    Conserved Domains (1) summary
    cl28094
    Location:35 → 183
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  15. NM_001350593.2 → NP_001337522.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variants 8-14 and 16-19, encodes isoform e.
    Source sequence(s)
    AL035689
    Conserved Domains (1) summary
    cl28094
    Location:35 → 183
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  16. NM_001350594.2 → NP_001337523.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variants 8-15 and 17-19, encodes isoform e.
    Source sequence(s)
    AL035689
    Conserved Domains (1) summary
    cl28094
    Location:35 → 183
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  17. NM_001350595.2 → NP_001337524.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17), as well as variants 8-16, 18, and 19, encodes isoform e.
    Source sequence(s)
    AL035689
    Conserved Domains (1) summary
    cl28094
    Location:35 → 183
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  18. NM_001350596.2 → NP_001337525.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18), as well as variants 8-17 and 19, encodes isoform e.
    Source sequence(s)
    AL035689
    Conserved Domains (1) summary
    cl28094
    Location:35 → 183
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

  19. NM_001350597.2 → NP_001337526.1  tRNA (guanine(10)-N2)-methyltransferase homolog isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19), as well as variants 8-18, encodes isoform e.
    Source sequence(s)
    AL035689
    Conserved Domains (1) summary
    cl28094
    Location:35 → 183
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]

RNA

  1. NR_146795.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL035689
    Related
    ENST00000479748.5

  2. NR_146796.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL035689

  3. NR_146797.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL035689, AL391115

  4. NR_146798.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL035689

  5. NR_146799.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL035689, AL391115

  6. NR_146800.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL035689

  7. NR_146801.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL035689

  8. NR_146802.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL035689

  9. NR_146803.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL035689, AL391115

  10. NR_146804.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL035689, AL391115

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    125986540..126272343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007059327.1 RNA Sequence

  2. XR_007059304.1 RNA Sequence

  3. XR_007059310.1 RNA Sequence

  4. XR_007059309.1 RNA Sequence

  5. XR_007059298.1 RNA Sequence

  6. XR_007059293.1 RNA Sequence

  7. XR_007059296.1 RNA Sequence

  8. XR_007059311.1 RNA Sequence

  9. XR_007059324.1 RNA Sequence

  10. XR_007059325.1 RNA Sequence

  11. XR_007059326.1 RNA Sequence

  12. XR_007059301.1 RNA Sequence

  13. XR_007059299.1 RNA Sequence

  14. XR_007059297.1 RNA Sequence

  15. XR_007059290.1 RNA Sequence

  16. XR_007059302.1 RNA Sequence

  17. XR_007059314.1 RNA Sequence

  18. XR_007059289.1 RNA Sequence

  19. XR_007059303.1 RNA Sequence

  20. XR_007059307.1 RNA Sequence

  21. XR_007059312.1 RNA Sequence

  22. XR_007059291.1 RNA Sequence

  23. XR_007059306.1 RNA Sequence

  24. XR_007059295.1 RNA Sequence

  25. XR_007059313.1 RNA Sequence

  26. XR_007059322.1 RNA Sequence

  27. XR_007059323.1 RNA Sequence

  28. XR_007059316.1 RNA Sequence

  29. XR_007059317.1 RNA Sequence

  30. XR_007059320.1 RNA Sequence

  31. XR_007059305.1 RNA Sequence

  32. XR_007059321.1 RNA Sequence

  33. XR_007059300.1 RNA Sequence

  34. XR_007059294.1 RNA Sequence

  35. XR_007059315.1 RNA Sequence

  36. XR_007059292.1 RNA Sequence

  37. XR_007059318.1 RNA Sequence

  38. XR_007059319.1 RNA Sequence

  39. XR_007059308.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    127175155..127468301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008487421.1 RNA Sequence

  2. XR_008487389.1 RNA Sequence

  3. XR_008487395.1 RNA Sequence

  4. XR_008487394.1 RNA Sequence

  5. XR_008487383.1 RNA Sequence

  6. XR_008487379.1 RNA Sequence

  7. XR_008487382.1 RNA Sequence

  8. XR_008487396.1 RNA Sequence

  9. XR_008487419.1 RNA Sequence

  10. XR_008487420.1 RNA Sequence

  11. XR_008487386.1 RNA Sequence

  12. XR_008487384.1 RNA Sequence

  13. XR_008487376.1 RNA Sequence

  14. XR_008487387.1 RNA Sequence

  15. XR_008487375.1 RNA Sequence

  16. XR_008487388.1 RNA Sequence

  17. XR_008487392.1 RNA Sequence

  18. XR_008487397.1 RNA Sequence

  19. XR_008487377.1 RNA Sequence

  20. XR_008487391.1 RNA Sequence

  21. XR_008487381.1 RNA Sequence

  22. XR_008487398.1 RNA Sequence

  23. XR_008487417.1 RNA Sequence

  24. XR_008487400.1 RNA Sequence

  25. XR_008487401.1 RNA Sequence

  26. XR_008487399.1 RNA Sequence

  27. XR_008487403.1 RNA Sequence

  28. XR_008487405.1 RNA Sequence

  29. XR_008487402.1 RNA Sequence

  30. XR_008487404.1 RNA Sequence

  31. XR_008487406.1 RNA Sequence

  32. XR_008487407.1 RNA Sequence

  33. XR_008487413.1 RNA Sequence

  34. XR_008487416.1 RNA Sequence

  35. XR_008487418.1 RNA Sequence

  36. XR_008487410.1 RNA Sequence

  37. XR_008487414.1 RNA Sequence

  38. XR_008487390.1 RNA Sequence

  39. XR_008487415.1 RNA Sequence

  40. XR_008487385.1 RNA Sequence

  41. XR_008487380.1 RNA Sequence

  42. XR_008487409.1 RNA Sequence

  43. XR_008487378.1 RNA Sequence

  44. XR_008487411.1 RNA Sequence

  45. XR_008487412.1 RNA Sequence

  46. XR_008487393.1 RNA Sequence

  47. XR_008487408.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_021820.1: Suppressed sequence

    Description
    NM_021820.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate; both the transcript and the protein have no support.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z4G4.1 GenPept UniProtKB/Swiss-Prot:Q7Z4G4

Gene LinkOut

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