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RGS13 regulator of G protein signaling 13 [ Homo sapiens (human) ]

Gene ID: 6003, updated on 5-Mar-2024

Summary

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Official Symbol
RGS13provided by HGNC
Official Full Name
regulator of G protein signaling 13provided by HGNC
Primary source
HGNC:HGNC:9995
See related
Ensembl:ENSG00000127074 MIM:607190; AllianceGenome:HGNC:9995
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lymph node (RPKM 52.7), appendix (RPKM 9.2) and 2 other tissues See more
Orthologs
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Genomic context

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Location:
1q31.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (192636147..192660311)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (191983284..192007378)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (192605277..192629441)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371664 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2263 Neighboring gene regulator of G protein signaling 1 Neighboring gene uncharacterized LOC107985241 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:192637387-192637888 Neighboring gene HNF1 motif-containing MPRA enhancer 26 Neighboring gene ribosomal protein S27a pseudogene 5 Neighboring gene microRNA 4426 Neighboring gene uncharacterized LOC105371665

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization. Han JI, et al. J Leukoc Biol, 2006 Jun. PMID 16565322
  2. Functional characterization of the G protein regulator RGS13. Johnson EN, et al. J Biol Chem, 2002 May 10. PMID 11875076
  3. MicroRNA and mRNA expression associated with ectopic germinal centers in thymus of myasthenia gravis. Sengupta M, et al. PLoS One, 2018. PMID 30308012, Free PMC Article
  4. Phosphorylation of RGS13 by the cyclic AMP-dependent protein kinase inhibits RGS13 degradation. Xie Z, et al. J Mol Cell Biol, 2010 Dec. PMID 20974683, Free PMC Article
  5. RGS13 controls g protein-coupled receptor-evoked responses of human mast cells. Bansal G, et al. J Immunol, 2008 Dec 1. PMID 19017978, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study demonstrates for the first time that miR-139 and miR-452 negatively regulate RGS13 expression which is known to be involved in germinal centers regulation.
    Title: MicroRNA and mRNA expression associated with ectopic germinal centers in thymus of myasthenia gravis.
  2. p53 may modulate immune responses through suppression of RGS13 transcription in mast cells and B cells
    Title: p53 negatively regulates RGS13 protein expression in immune cells.
  3. RGS13 turnover was significantly reduced in cells stimulated with cAMP, which was reversed by expression of the PKA-specific inhibitory peptide PKI.
    Title: Phosphorylation of RGS13 by the cyclic AMP-dependent protein kinase inhibits RGS13 degradation.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.
  5. RGS13 overexpression inhibited CXCL12-evoked Ca(2+) mobilization, Akt phosphorylation and chemotaxis.
    Title: RGS13 controls g protein-coupled receptor-evoked responses of human mast cells.
  6. Functional characterization of the G protein regulator RGS13
    Title: Functional characterization of the G protein regulator RGS13.
  7. Down-Regulation of regulator of G-protein signalling 13 is associated with mantle cell lymphoma
    Title: High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma.
  8. RGS1 and RGS13 act together to regulate chemokine receptor signaling in human germinal center B lymphocytes and contribute significantly to the rapid desensitization of the signaling pathway.
    Title: RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC17173

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
  
involved_in negative regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
regulator of G-protein signaling 13
Names
regulator of G-protein signalling 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002927.5 → NP_002918.1  regulator of G-protein signaling 13

    See identical proteins and their annotated locations for NP_002918.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AL136454, AL596119
    Consensus CDS
    CCDS1376.1
    UniProtKB/Swiss-Prot
    O14921, Q6PGR2, Q8TD63, Q9BX45
    Related
    ENSP00000375853.2, ENST00000391995.7
    Conserved Domains (1) summary
    cd08716
    Location:35 → 148
    RGS_RGS13; Regulator of G protein signaling (RGS) domain found in the RGS13 protein

  2. NM_144766.3 → NP_658912.1  regulator of G-protein signaling 13

    See identical proteins and their annotated locations for NP_658912.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL136454, AL596119
    Consensus CDS
    CCDS1376.1
    UniProtKB/Swiss-Prot
    O14921, Q6PGR2, Q8TD63, Q9BX45
    Related
    ENSP00000442837.1, ENST00000543215.5
    Conserved Domains (1) summary
    cd08716
    Location:35 → 148
    RGS_RGS13; Regulator of G protein signaling (RGS) domain found in the RGS13 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    192636147..192660311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    191983284..192007378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14921.1 GenPept UniProtKB/Swiss-Prot:O14921

Gene LinkOut

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