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Myl10 myosin, light chain 10, regulatory [ Mus musculus (house mouse) ]

Gene ID: 59310, updated on 11-Apr-2024

Summary

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Official Symbol
Myl10provided by MGI
Official Full Name
myosin, light chain 10, regulatoryprovided by MGI
Primary source
MGI:MGI:1891705
See related
Ensembl:ENSMUSG00000005474 AllianceGenome:MGI:1891705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PLRLC; Mylc2pl; 1700027I08Rik
Summary
Predicted to enable calcium ion binding activity. Located in mitochondrion. Orthologous to human MYL10 (myosin light chain 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 7.7) See more
Orthologs
human all
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Genomic context

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Location:
5 G2; 5 76.03 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (136717749..136730711)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (136688892..136701857)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene cut-like homeobox 1 Neighboring gene STARR-seq mESC enhancer starr_14620 Neighboring gene predicted gene, 54307 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:137026660-137026843 Neighboring gene STARR-seq mESC enhancer starr_14621 Neighboring gene STARR-positive B cell enhancer ABC_E4794 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:137093643-137093839 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:137093950-137094103 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:137099197-137099306 Neighboring gene predicted gene, 38722 Neighboring gene collagen, type XXVI, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_14627 Neighboring gene VISTA enhancer mm1626 Neighboring gene predicted gene, 30654 Neighboring gene predicted gene 20485

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible. Oltz EM, et al. EMBO J, 1992 Jul. PMID 1628631, Free PMC Article
  2. Protein partners of dynamin-1 in the retina. Grossman GH, et al. Vis Neurosci, 2013 Jul. PMID 23746204, Free PMC Article
  3. Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca(2+)/CaM) and CaM Kinase II (CaMKII) Binding Partner. Evans PR, et al. J Proteome Res, 2018 Apr 6. PMID 29518331, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myosin regulatory light chain 10
Names
myosin light chain 2, precursor lymphocyte-specific
precursor lymphocyte-specific regulatory light chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085387.2 → NP_001078856.1  myosin regulatory light chain 10 isoform 2

    See identical proteins and their annotated locations for NP_001078856.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as "PLRLC-A") uses an alternate 5' terminal exon resulting in a distinct 5' UTR and the use of an in-frame downstream start codon, compared to variant 1. This results in isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same isoform (2).
    Source sequence(s)
    AC087329, CJ236701
    Consensus CDS
    CCDS80434.1
    UniProtKB/Swiss-Prot
    Q62082
    Related
    ENSMUSP00000143165.2, ENSMUST00000197186.2
    Conserved Domains (1) summary
    COG5126
    Location:1 → 128
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  2. NM_001303019.1 → NP_001289948.1  myosin regulatory light chain 10 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3, also known as "PLRLC-C") contains an alternate exon in the central coding region which results in a frameshift, compared to variant 1. This results in isoform 3 which is shorter and has a unique C-terminus compared to isoform 1.
    Source sequence(s)
    AC087329, CJ236701
    Consensus CDS
    CCDS80433.1
    UniProtKB/TrEMBL
    A0A0G2JDZ4
    Related
    ENSMUSP00000142570.2, ENSMUST00000196068.5
    Conserved Domains (1) summary
    cd00051
    Location:9 → 67
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. NM_001303021.1 → NP_001289950.1  myosin regulatory light chain 10 isoform 2

    See identical proteins and their annotated locations for NP_001289950.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' terminal exon resulting in a distinct 5' UTR and the use of an in-frame downstream start codon, compared to variant 1. This results in isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same isoform (2).
    Source sequence(s)
    CJ236701
    Consensus CDS
    CCDS80434.1
    UniProtKB/Swiss-Prot
    Q62082
    Related
    ENSMUSP00000142495.2, ENSMUST00000196436.5
    Conserved Domains (1) summary
    COG5126
    Location:1 → 128
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  4. NM_021611.3 → NP_067624.2  myosin regulatory light chain 10 isoform 1

    See identical proteins and their annotated locations for NP_067624.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC087329, CJ236701
    Consensus CDS
    CCDS51668.1
    UniProtKB/TrEMBL
    E9QNY3
    Related
    ENSMUSP00000005611.6, ENSMUST00000005611.10
    Conserved Domains (1) summary
    COG5126
    Location:1 → 144
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    136717749..136730711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321050.2 → XP_017176539.1  myosin regulatory light chain 10 isoform X1

    Conserved Domains (1) summary
    COG5126
    Location:44 → 164
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  2. XM_017321051.3 → XP_017176540.2  myosin regulatory light chain 10 isoform X2

    Conserved Domains (1) summary
    COG5126
    Location:20 → 123
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62082.1 GenPept UniProtKB/Swiss-Prot:Q62082

Gene LinkOut

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