Dctn5 dynactin 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dctn5provided by MGI
Official Full Name: dynactin 5provided by MGI
Primary source: MGI:MGI:1891689
See related: Ensembl:ENSMUSG00000030868 AllianceGenome:MGI:1891689
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: b2b315Clo; 4930427E12Rik
Summary: Acts upstream of or within aorta development; coronary vasculature development; and ventricular septum development. Predicted to be located in centrosome; nuclear membrane; and nucleoplasm. Predicted to be part of dynactin complex. Is expressed in cervical ganglion; cervico-thoracic ganglion; dorsal root ganglion; glossopharyngeal ganglion; and trigeminal ganglion. Orthologous to human DCTN5 (dynactin subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 35.2), CNS E18 (RPKM 35.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F2; 7 65.47 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (121732264..121748267)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (122133041..122149044)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (3)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW742216 (e-PCR)
- UniSTS:208197

RH126319 (e-PCR)
- UniSTS:163027

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within coronary vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular septum development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of dynactin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of dynactin complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dynactin subunit 5

Names: dynactin 4; dynactin subunit p25; p25 dynactin subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021608.3 → NP_067621.3 dynactin subunit 5

See identical proteins and their annotated locations for NP_067621.3

Status: VALIDATED

Source sequence(s)

AK076738, AK151876

Consensus CDS

CCDS21811.1

UniProtKB/Swiss-Prot

Q3U9A4, Q8BPE5, Q91XC6, Q99J17, Q9QZB9

UniProtKB/TrEMBL

Q3UK85

Related

ENSMUSP00000033156.5, ENSMUST00000033156.5

Conserved Domains (1) summary

cd03359
Location:13 → 173

LbH_Dynactin_5; Dynactin 5 (or subunit p25); Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...