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Rab37 RAB37, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 58222, updated on 11-Apr-2024

Summary

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Official Symbol
Rab37provided by MGI
Official Full Name
RAB37, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:1929945
See related
Ensembl:ENSMUSG00000020732 AllianceGenome:MGI:1929945
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B230331O03Rik; B230354I04Rik
Summary
Predicted to enable GTPase activity. Predicted to act upstream of or within protein transport. Located in secretory granule. Is expressed in brain and retina. Orthologous to human RAB37 (RAB37, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 5.8), frontal lobe adult (RPKM 3.4) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Rab37 in Genome Data Viewer
Location:
11 E2; 11 80.59 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (114982257..115053066)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115091331..115162773)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31142 Neighboring gene CD300 molecule like family member D3 Neighboring gene CD300E molecule Neighboring gene STARR-seq mESC enhancer starr_31143 Neighboring gene STARR-seq mESC enhancer starr_31145 Neighboring gene STARR-positive B cell enhancer mm9_chr11:114966559-114966859 Neighboring gene STARR-positive B cell enhancer mm9_chr11:114967952-114968253 Neighboring gene CD300 molecule like family member F Neighboring gene STARR-positive B cell enhancer ABC_E11499 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115019296-115019604 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115024157-115024344 Neighboring gene STARR-positive B cell enhancer ABC_E91 Neighboring gene NHERF family PDZ scaffold protein 1 Neighboring gene STARR-positive B cell enhancer mm9_chr11:115048516-115048817 Neighboring gene transmembrane protein 104 Neighboring gene N-acetyltransferase 9 (GCN5-related, putative)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rab37 Promotes Endothelial Differentiation and Accelerates ADSC-Mediated Diabetic Wound Healing through Regulating Secretion of Hsp90α and TIMP1. Huang H, et al. Stem Cell Rev Rep, 2023 May. PMID 36627432
  2. Secretory autophagy promotes Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1. Wu SY, et al. J Biomed Sci, 2022 Dec 2. PMID 36457117, Free PMC Article
  3. Secretory autophagy promotes RAB37-mediated insulin secretion under glucose stimulation both in vitro and in vivo. Wu SY, et al. Autophagy, 2023 Apr. PMID 36109708, Free PMC Article
  4. Release of TNF-α from macrophages is mediated by small GTPase Rab37. Mori R, et al. Eur J Immunol, 2011 Nov. PMID 21805469
  5. Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment. Kuo IY, et al. Theranostics, 2021. PMID 34093869, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rab37 mediates trafficking and membrane presentation of PD-1 to sustain T cell exhaustion in lung cancer.
    Title: Rab37 mediates trafficking and membrane presentation of PD-1 to sustain T cell exhaustion in lung cancer.
  2. Rab37 Promotes Endothelial Differentiation and Accelerates ADSC-Mediated Diabetic Wound Healing through Regulating Secretion of Hsp90alpha and TIMP1.
    Title: Rab37 Promotes Endothelial Differentiation and Accelerates ADSC-Mediated Diabetic Wound Healing through Regulating Secretion of Hsp90α and TIMP1.
  3. Secretory autophagy promotes Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1.
    Title: Secretory autophagy promotes Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1.
  4. Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment.
    Title: Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment.
  5. RAB37 regulates the exocytosis of TIMP1 in a nucleotide-dependent manner to inactivate MMP9 migration axis in vitro and in vivo and to suppress tumor metastasis.
    Title: Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis.
  6. Rab37 interacts with Munc13-1 to control TNF-alpha secretion from activated macrophages
    Title: Release of TNF-α from macrophages is mediated by small GTPase Rab37.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC157622

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in secretory granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ras-related protein Rab-37
Names
GTPase Rab37
RAB37, member of RAS oncogene family

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163753.1 → NP_001157225.1  ras-related protein Rab-37 isoform 2

    See identical proteins and their annotated locations for NP_001157225.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs at the 5' end, and is missing two in-frame coding exons compared to variant 1. This results in a shorter isoform (2) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK046260, BB084455
    Consensus CDS
    CCDS48979.1
    UniProtKB/TrEMBL
    Q8BQX0
    Related
    ENSMUSP00000065016.5, ENSMUST00000067754.11
    Conserved Domains (1) summary
    cd04112
    Location:23 → 213
    Rab26; Rab GTPase family 26 (Rab26)

  2. NM_021411.4 → NP_067386.3  ras-related protein Rab-37 isoform 1

    See identical proteins and their annotated locations for NP_067386.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK040216, AK050483, BB084455, BY131048
    Consensus CDS
    CCDS25620.1
    UniProtKB/Swiss-Prot
    Q8C7E1, Q9JKM7
    UniProtKB/TrEMBL
    Q544E8
    Related
    ENSMUSP00000021076.6, ENSMUST00000021076.6
    Conserved Domains (1) summary
    cd04112
    Location:31 → 220
    Rab26; Rab GTPase family 26 (Rab26)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    114982257..115053066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156872.1 → XP_036012765.1  ras-related protein Rab-37 isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:31 → 144
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_003949483.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JKM7.2 GenPept UniProtKB/Swiss-Prot:Q9JKM7

Gene LinkOut

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