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Zbp1 Z-DNA binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 58203, updated on 21-Apr-2024

Summary

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Official Symbol
Zbp1provided by MGI
Official Full Name
Z-DNA binding protein 1provided by MGI
Primary source
MGI:MGI:1927449
See related
Ensembl:ENSMUSG00000027514 AllianceGenome:MGI:1927449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dai; Dlm1; mZaDLM; 2010010H03Rik
Summary
Enables double-stranded RNA binding activity and left-handed Z-DNA binding activity. Involved in several processes, including positive regulation of defense response; positive regulation of programmed cell death; and regulation of interleukin-1-mediated signaling pathway. Acts upstream of or within positive regulation of type I interferon-mediated signaling pathway. Located in cytoplasm and nucleus. Is expressed in eye and heart. Orthologous to human ZBP1 (Z-DNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 22.2), thymus adult (RPKM 15.0) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H3; 2 95.83 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (173048405..173060715, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (173206612..173218959, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06610 Neighboring gene predicted gene, 36691 Neighboring gene predicted gene, 36749 Neighboring gene STARR-positive B cell enhancer ABC_E9076 Neighboring gene phosphoenolpyruvate carboxykinase 1, cytosolic Neighboring gene STARR-seq mESC enhancer starr_06613 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:173055154-173055337 Neighboring gene prostate transmembrane protein, androgen induced 1 Neighboring gene STARR-seq mESC enhancer starr_06615 Neighboring gene prostate transmembrane protein, androgen induced 1, opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inhibition of DAI refrains dendritic cells from maturation and prolongs murine islet and skin allograft survival. Cheng P, et al. Front Immunol, 2023. PMID 37197662, Free PMC Article
  2. ZBP1 Protects Against mtDNA-Induced Myocardial Inflammation in Failing Hearts. Enzan N, et al. Circ Res, 2023 Apr 28. PMID 36974722, Free PMC Article
  3. ZBP1 promotes inflammatory responses downstream of TLR3/TLR4 via timely delivery of RIPK1 to TRIF. Muendlein HI, et al. Proc Natl Acad Sci U S A, 2022 Jun 14. PMID 35666872, Free PMC Article
  4. Z-DNA binding protein 1 mediates necroptotic and apoptotic cell death pathways in murine astrocytes following herpes simplex virus-1 infection. Jeffries AM, et al. J Neuroinflammation, 2022 May 13. PMID 35549723, Free PMC Article
  5. Zbp1-positive cells are osteogenic progenitors in periodontal ligament. Ueda T, et al. Sci Rep, 2021 Apr 6. PMID 33824390, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZBP1 activation triggers hematopoietic stem and progenitor cell death resulting in bone marrow failure in mice.
    Title: ZBP1 activation triggers hematopoietic stem and progenitor cell death resulting in bone marrow failure in mice.
  2. Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and NLRP12-PANoptosome activation and inflammatory cell death (PANoptosis).
    Title: Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and NLRP12-PANoptosome activation and inflammatory cell death (PANoptosis).
  3. Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity.
    Title: Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity.
  4. Inhibition of DAI refrains dendritic cells from maturation and prolongs murine islet and skin allograft survival.
    Title: Inhibition of DAI refrains dendritic cells from maturation and prolongs murine islet and skin allograft survival.
  5. ZBP1 Protects Against mtDNA-Induced Myocardial Inflammation in Failing Hearts.
    Title: ZBP1 Protects Against mtDNA-Induced Myocardial Inflammation in Failing Hearts.
  6. SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote virus-induced inflammatory responses.
    Title: SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote virus-induced inflammatory responses.
  7. Differential transcriptomic changes in the central nervous system and urinary bladders of mice infected with a coronavirus.
    Title: Differential transcriptomic changes in the central nervous system and urinary bladders of mice infected with a coronavirus.
  8. Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis.
    Title: Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis.
  9. ADAR1 averts fatal type I interferon induction by ZBP1.
    Title: ADAR1 averts fatal type I interferon induction by ZBP1.
  10. ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis.
    Title: ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded RNA adenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables left-handed Z-DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in activation of innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of necroptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of necroptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type I interferon-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within programmed cell death IEA
Inferred from Electronic Annotation
more info
  
involved_in pyroptosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of interleukin-1-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
Z-DNA-binding protein 1
Names
DNA-dependent activator of IFN-regulatory factors
tumor stroma and activated macrophage protein DLM-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001139519.1 → NP_001132991.1  Z-DNA-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001132991.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and has multiple differences in the 3' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK008179, BY170802
    Consensus CDS
    CCDS50813.1
    UniProtKB/Swiss-Prot
    Q9QY24
    Related
    ENSMUSP00000104744.3, ENSMUST00000109116.3
    Conserved Domains (1) summary
    cl02659
    Location:8 → 72
    z-alpha; Adenosine deaminase z-alpha domain

  2. NM_021394.2 → NP_067369.2  Z-DNA-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_067369.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI643886, AL837509, AX775969, BY170802
    Consensus CDS
    CCDS17142.1
    UniProtKB/Swiss-Prot
    Q8VE02, Q9D8B9, Q9QY24
    UniProtKB/TrEMBL
    A2APF7
    Related
    ENSMUSP00000029018.8, ENSMUST00000029018.14
    Conserved Domains (2) summary
    smart00550
    Location:8 → 72
    Zalpha; Z-DNA-binding domain in adenosine deaminases
    cl02659
    Location:84 → 147
    z-alpha; Adenosine deaminase z-alpha domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    173048405..173060715 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QY24.1 GenPept UniProtKB/Swiss-Prot:Q9QY24

Gene LinkOut

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