Ppp1r1a protein phosphatase 1, regulatory inhibitor subunit 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp1r1aprovided by MGI
Official Full Name: protein phosphatase 1, regulatory inhibitor subunit 1Aprovided by MGI
Primary source: MGI:MGI:1889595
See related: Ensembl:ENSMUSG00000022490 AllianceGenome:MGI:1889595
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: I-1; 0610038N18Rik
Summary: Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within glycogen metabolic process. Predicted to be located in extracellular space. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; gonad; intraembryonic coelom; sensory organ; and skin. Orthologous to human PPP1R1A (protein phosphatase 1 regulatory inhibitor subunit 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 53.9), mammary gland adult (RPKM 24.9) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F3; 15 59.01 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (103438706..103446465, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (103530279..103538027, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exploring prognostic value and regulation network of PPP1R1A in hepatocellular carcinoma.
Title: Exploring prognostic value and regulation network of PPP1R1A in hepatocellular carcinoma.
A2a receptor increase cell viability, proliferation and insulin release through PKA/Akt/IPP-1/CREB signaling pathway
Title: IPP-1 controls Akt/CREB phosphorylation extension in A(2a) adenosine receptor signaling cascade in MIN6 pancreatic β-cell line.
High PPP1R1A expression is associated with ewing sarcoma tumorigenesis and metastasis.
Title: Protein phosphatase 1 regulatory subunit 1A in ewing sarcoma tumorigenesis and metastasis.
I-1 and sarco/endoplasmic reticulum Ca2+ -ATPase synergistically induce the vascular smooth muscle cell contractile phenotype.
Title: Synergistic role of protein phosphatase inhibitor 1 and sarco/endoplasmic reticulum Ca2+ -ATPase in the acquisition of the contractile phenotype of arterial smooth muscle cells.
These data indicate a potential role for DARPP-32 and inhibitor-1 in the regulation of PP1 activity in pancreatic beta-cell stimulus-secretion coupling.
Title: DARPP-32 and inhibitor-1 are expressed in pancreatic beta-cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycogen metabolic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein phosphatase 1 regulatory subunit 1A

Names: IPP-1; inhibitor-1; protein phosphatase inhibitor 1

NP_067366.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.