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apaf1 apoptotic peptidase activating factor 1 [ Danio rerio (zebrafish) ]

Gene ID: 58131, updated on 14-Apr-2024

Summary

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Official Symbol
apaf1provided by ZNC
Official Full Name
apoptotic peptidase activating factor 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-000616-4
See related
Ensembl:ENSDARG00000021239 AllianceGenome:ZFIN:ZDB-GENE-000616-4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
apaf-1; zgc:136543
Summary
Predicted to enable ADP binding activity; ATP binding activity; and peptidase activity. Predicted to act upstream of or within apoptotic signaling pathway; proteolysis; and regulation of apoptotic process. Predicted to be located in cytoplasm. Predicted to be part of apoptosome. Orthologous to human APAF1 (apoptotic peptidase activating factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
28
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (17830759..17873579)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (17854731..17884595)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B9b Neighboring gene Spi-C transcription factor (Spi-1/PU.1 related) Neighboring gene arginine vasopressin receptor 2, like Neighboring gene uncharacterized LOC103910447 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity. Orzáez M, et al. PLoS One, 2014. PMID 25330150, Free PMC Article
  2. Chronic Toxic Effects of Flutolanil on the Liver of Zebrafish ( Danio rerio). Teng M, et al. Chem Res Toxicol, 2019 Jun 17. PMID 30942079
  3. Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria-mediated apoptosis in zebrafish embryos. Zhao X, et al. Aquat Toxicol, 2016 Nov. PMID 27658222
  4. Enantioselective bioaccumulation of hexaconazole and its toxic effects in adult zebrafish (Danio rerio). Wang Y, et al. Chemosphere, 2015 Nov. PMID 26291761
  5. α-asarone induces cardiac defects and QT prolongation through mitochondrial apoptosis pathway in zebrafish. Shang X, et al. Toxicol Lett, 2020 May 15. PMID 32035120

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results provide evidence that Apaf-1 pharmacological inhibition has therapeutic potential for the treatment of apoptosis-related diseases.
    Title: Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC92565, MGC136543

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ADP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of apoptosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
apoptotic protease-activating factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131608.1 → NP_571683.1  apoptotic protease-activating factor 1

    See identical proteins and their annotated locations for NP_571683.1

    Status: PROVISIONAL

    Source sequence(s)
    AF251502
    UniProtKB/Swiss-Prot
    Q9I9H8
    Conserved Domains (6) summary
    COG2319
    Location:641 → 1042
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:616 → 912
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam00931
    Location:132 → 411
    NB-ARC; NB-ARC domain
    sd00039
    Location:625 → 657
    7WD40; WD40 repeat [structural motif]
    cl14633
    Location:7 → 92
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl21455
    Location:150 → 297
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    17830759..17873579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021475139.1 → XP_021330814.1  apoptotic protease-activating factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BC28, A5WVJ8, E7F2V1
    Related
    ENSDARP00000008347.6, ENSDART00000019165.8
    Conserved Domains (4) summary
    cd00200
    Location:616 → 912
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd08323
    Location:7 → 92
    CARD_APAF1; Caspase activation and recruitment domain similar to that found in Apoptotic Protease-Activating Factor 1
    sd00039
    Location:625 → 657
    7WD40; WD40 repeat [structural motif]
    pfam00931
    Location:132 → 415
    NB-ARC; NB-ARC domain

  2. XM_005164770.4 → XP_005164827.1  apoptotic protease-activating factor 1 isoform X1

    See identical proteins and their annotated locations for XP_005164827.1

    UniProtKB/TrEMBL
    A0A8M2BC28, A5WVJ8, E7F2V1
    Conserved Domains (4) summary
    cd00200
    Location:616 → 912
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd08323
    Location:7 → 92
    CARD_APAF1; Caspase activation and recruitment domain similar to that found in Apoptotic Protease-Activating Factor 1
    sd00039
    Location:625 → 657
    7WD40; WD40 repeat [structural motif]
    pfam00931
    Location:132 → 415
    NB-ARC; NB-ARC domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9I9H8.1 GenPept UniProtKB/Swiss-Prot:Q9I9H8

Gene LinkOut

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