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gabpa GA binding protein transcription factor subunit alpha [ Danio rerio (zebrafish) ]

Gene ID: 58110, updated on 11-Apr-2024

Summary

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Official Symbol
gabpaprovided by ZNC
Official Full Name
GA binding protein transcription factor subunit alphaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-011010-2
See related
Ensembl:ENSDARG00000069289 AllianceGenome:ZFIN:ZDB-GENE-011010-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
e4tf; wu:fc12d11
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be active in nucleus. Is expressed in endothelial cell. Orthologous to human GABPA (GA binding protein transcription factor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (35014513..35025524)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (35205328..35216339)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene si:ch211-160b11.4 Neighboring gene junctional adhesion molecule 2b Neighboring gene amyloid beta (A4) precursor protein b Neighboring gene si:dkey-192g7.3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Thyroid hormone actions are temperature-specific and regulate thermal acclimation in zebrafish (Danio rerio). Little AG, et al. BMC Biol, 2013 Mar 26. PMID 23531055, Free PMC Article
  2. The repertoire of Na,K-ATPase alpha and beta subunit genes expressed in the zebrafish, Danio rerio. Rajarao SJ, et al. Genome Res, 2001 Jul. PMID 11435403, Free PMC Article
  3. Transcriptomic characterization of cold acclimation in larval zebrafish. Long Y, et al. BMC Genomics, 2013 Sep 11. PMID 24024969, Free PMC Article
  4. Single-cell analyses identify distinct and intermediate states of zebrafish pancreatic islet development. Lu CJ, et al. J Mol Cell Biol, 2019 Jun 1. PMID 30407522, Free PMC Article
  5. Toxicogenomic and phenotypic analyses of bisphenol-A early-life exposure toxicity in zebrafish. Lam SH, et al. PLoS One, 2011. PMID 22194820, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GA-binding protein alpha chain
Names
E4tf1-60 transcription factor
GA binding protein transcription factor, alpha subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328412.1 → NP_001315341.1  GA-binding protein alpha chain

    Status: VALIDATED

    Source sequence(s)
    CR759841, EH458961, EH546232
    UniProtKB/TrEMBL
    A0A2R8QCN2, F6NQQ6, Q9I9E8
    Related
    ENSDARP00000091473.4, ENSDART00000100700.6
    Conserved Domains (3) summary
    cd08534
    Location:162 → 248
    SAM_PNT-GABP-alpha; Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain
    smart00413
    Location:309 → 394
    ETS; erythroblast transformation specific domain
    pfam11620
    Location:40 → 118
    GABP-alpha; GA-binding protein alpha chain

  2. NM_131587.2 → NP_571662.1  GA-binding protein alpha chain

    See identical proteins and their annotated locations for NP_571662.1

    Status: VALIDATED

    Source sequence(s)
    CR759841, EH458961, EH546232
    UniProtKB/TrEMBL
    A0A2R8QCN2, F6NQQ6, Q9I9E8
    Related
    ENSDARP00000091474.3, ENSDART00000100701.5
    Conserved Domains (3) summary
    cd08534
    Location:162 → 248
    SAM_PNT-GABP-alpha; Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain
    smart00413
    Location:309 → 394
    ETS; erythroblast transformation specific domain
    pfam11620
    Location:40 → 118
    GABP-alpha; GA-binding protein alpha chain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    35014513..35025524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167853.4 → XP_005167910.1  GA-binding protein alpha chain isoform X1

    See identical proteins and their annotated locations for XP_005167910.1

    UniProtKB/TrEMBL
    A0A2R8QCN2, F6NQQ6, Q9I9E8
    Related
    ENSDARP00000150776.1, ENSDART00000182404.1
    Conserved Domains (3) summary
    cd08534
    Location:162 → 248
    SAM_PNT-GABP-alpha; Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain
    smart00413
    Location:309 → 394
    ETS; erythroblast transformation specific domain
    pfam11620
    Location:40 → 118
    GABP-alpha; GA-binding protein alpha chain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394760.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    305084..316623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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