tnnt3a troponin T type 3a (skeletal, fast) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tnnt3aprovided by ZNC
Official Full Name: troponin T type 3a (skeletal, fast)provided by ZNC
Primary source: ZFIN:ZDB-GENE-000322-3
See related: Ensembl:ENSDARG00000030270 AllianceGenome:ZFIN:ZDB-GENE-000322-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tnnt
Summary: Predicted to enable tropomyosin binding activity; troponin C binding activity; and troponin I binding activity. Acts upstream of or within sarcomere organization. Predicted to be part of troponin complex. Is expressed in musculature system and somite. Human ortholog(s) of this gene implicated in distal arthrogryposis type 2B and distal arthrogryposis type 2B2. Orthologous to human TNNT3 (troponin T3, fast skeletal type). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 25

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (31405184..31418457)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (30827756..30840981)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Complete loss of troponin T3a, T3b and T2c activities leads to loss of sarcomere structure.
Title: Troponin T is essential for sarcomere assembly in zebrafish skeletal muscle.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables tropomyosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables troponin C binding	IBA Inferred from Biological aspect of Ancestor more info
enables troponin I binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sarcomere organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of troponin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of troponin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: troponin T type 3a (skeletal, fast)

Names: troponin T, skeletal, fast; troponin T3a, skeletal, fast

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131565.1 → NP_571640.1 troponin T type 3a (skeletal, fast)

See identical proteins and their annotated locations for NP_571640.1

Status: PROVISIONAL

Source sequence(s)

AF180889

UniProtKB/TrEMBL

F6NWK6, Q789K7, Q9I8U9

Related

ENSDARP00000094172.4, ENSDART00000103395.6

Conserved Domains (1) summary

pfam00992
Location:39 → 175

Troponin; Troponin

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007136.7 Reference GRCz11 Primary Assembly

Range

31405184..31418457

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005163151.3 → XP_005163208.3 troponin T type 3a (skeletal, fast) isoform X1

UniProtKB/TrEMBL

A0A8M2BAI0

Conserved Domains (1) summary

pfam00992
Location:91 → 227

Troponin