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Sec61a2 SEC61 translocon subunit alpha 2 [ Mus musculus (house mouse) ]

Gene ID: 57743, updated on 3-Apr-2024

Summary

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Official Symbol
Sec61a2provided by MGI
Official Full Name
SEC61 translocon subunit alpha 2provided by MGI
Primary source
MGI:MGI:1931071
See related
Ensembl:ENSMUSG00000025816 AllianceGenome:MGI:1931071
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation and posttranslational protein targeting to membrane, translocation. Predicted to act upstream of or within protein transport. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be part of Sec61 translocon complex. Orthologous to human SEC61A2 (SEC61 translocon subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 18.1), CNS E18 (RPKM 14.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A1; 2 3.62 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (5875788..5900199, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (5870977..5895432, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cell division cycle 123 Neighboring gene predicted gene, 29984 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:5766095-5766344 Neighboring gene nudix hydrolase 5 Neighboring gene STARR-seq mESC enhancer starr_03579 Neighboring gene predicted gene 13199 Neighboring gene STARR-positive B cell enhancer mm9_chr2:5816293-5816594 Neighboring gene predicted gene 13267 Neighboring gene dehydrogenase E1 and transketolase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_03580 Neighboring gene STARR-positive B cell enhancer ABC_E2029 Neighboring gene STARR-seq mESC enhancer starr_03581 Neighboring gene UPF2 regulator of nonsense transcripts homolog (yeast)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum (ER) translocation sites, leads to ER stress. Hori O, et al. Mol Cell Biol, 2006 Jun. PMID 16705175, Free PMC Article
  2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables signal sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-translational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Sec61 translocon complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein transport protein Sec61 subunit alpha isoform 2; protein transport protein Sec61 subunit alpha
Names
Sec61 alpha
Sec61, alpha subunit 2
sec61 alpha-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356411.2 → NP_001343340.1  protein transport protein Sec61 subunit alpha isoform 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL928924
    Consensus CDS
    CCDS89425.1
    UniProtKB/TrEMBL
    Q3TJD0, Q9CYJ6
    Related
    ENSMUSP00000141333.2, ENSMUST00000193792.6
    Conserved Domains (1) summary
    PTZ00219
    Location:1 → 403
    PTZ00219; Sec61 alpha subunit; Provisional

  2. NM_001421820.1 → NP_001408749.1  protein transport protein Sec61 subunit alpha isoform 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL928924

  3. NM_001421821.1 → NP_001408750.1  protein transport protein Sec61 subunit alpha isoform 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL928924

  4. NM_001421822.1 → NP_001408751.1  protein transport protein Sec61 subunit alpha isoform 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL928924

  5. NM_001421823.1 → NP_001408752.1  protein transport protein Sec61 subunit alpha isoform 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL928924

  6. NM_001421824.1 → NP_001408753.1  protein transport protein Sec61 subunit alpha isoform 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL928924

  7. NM_021305.5 → NP_067280.1  protein transport protein Sec61 subunit alpha isoform 2 isoform 1

    See identical proteins and their annotated locations for NP_067280.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL928924
    Consensus CDS
    CCDS15668.1
    UniProtKB/Swiss-Prot
    Q9JLR1
    UniProtKB/TrEMBL
    Q3TJD0
    Related
    ENSMUSP00000100046.4, ENSMUST00000102981.10
    Conserved Domains (1) summary
    PTZ00219
    Location:1 → 469
    PTZ00219; Sec61 alpha subunit; Provisional

RNA

  1. NR_185332.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL928924

  2. NR_185333.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL928924

  3. NR_185334.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL928924

  4. NR_185335.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL928924

  5. NR_185336.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL928924

  6. NR_185337.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL928924

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    5875788..5900199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162431.1 → XP_036018324.1  protein transport protein Sec61 subunit alpha isoform X2

    Conserved Domains (1) summary
    PTZ00219
    Location:8 → 270
    PTZ00219; Sec61 alpha subunit; Provisional

  2. XM_006497517.5 → XP_006497580.1  protein transport protein Sec61 subunit alpha isoform X2

    Conserved Domains (1) summary
    PTZ00219
    Location:8 → 270
    PTZ00219; Sec61 alpha subunit; Provisional

  3. XM_030251912.2 → XP_030107772.1  protein transport protein Sec61 subunit alpha isoform X2

    Conserved Domains (1) summary
    PTZ00219
    Location:8 → 270
    PTZ00219; Sec61 alpha subunit; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JLR1.3 GenPept UniProtKB/Swiss-Prot:Q9JLR1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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