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Zfp276 zinc finger protein (C2H2 type) 276 [ Mus musculus (house mouse) ]

Gene ID: 57247, updated on 30-Apr-2024

Summary

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Official Symbol
Zfp276provided by MGI
Official Full Name
zinc finger protein (C2H2 type) 276provided by MGI
Primary source
MGI:MGI:1888495
See related
Ensembl:ENSMUSG00000001065 AllianceGenome:MGI:1888495
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf276; D8Ertd370e; D8Ertd377e
Summary
Predicted to enable chromatin insulator sequence binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromosome, centromeric region and nucleus. Predicted to be active in kinetochore. Is expressed in several structures, including genitourinary system; liver; nervous system; sensory organ; and spleen. Orthologous to human ZNF276 (zinc finger protein 276). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 15.1), ovary adult (RPKM 11.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 72.09 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123980934..123997290)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123254195..123270551)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933417D19 gene Neighboring gene cyclin dependent kinase 10 Neighboring gene spermatogenesis associated 2-like Neighboring gene VPS9 domain containing 1 Neighboring gene Fanconi anemia, complementation group A Neighboring gene STARR-positive B cell enhancer ABC_E8971 Neighboring gene STARR-seq mESC enhancer starr_22969 Neighboring gene STARR-seq mESC enhancer starr_22970 Neighboring gene spire type actin nucleation factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E2278 Neighboring gene transcription factor 25 (basic helix-loop-helix)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcription factor Zfp276 drives oligodendroglial differentiation and myelination by switching off the progenitor cell program. Aberle T, et al. Nucleic Acids Res, 2022 Feb 28. PMID 35137157, Free PMC Article
  2. Cloning and analysis of the mouse Fanconi anemia group A cDNA and an overlapping penta zinc finger cDNA. Wong JC, et al. Genomics, 2000 Aug 1. PMID 10936049
  3. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  4. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transcription factor Zfp276 drives oligodendroglial differentiation and myelination by switching off the progenitor cell program.
    Title: Transcription factor Zfp276 drives oligodendroglial differentiation and myelination by switching off the progenitor cell program.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin insulator sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 276
Names
zfp-276

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020497.2 → NP_065243.2  zinc finger protein 276

    See identical proteins and their annotated locations for NP_065243.2

    Status: VALIDATED

    Source sequence(s)
    AK028939, AK133363, BE690413
    Consensus CDS
    CCDS52699.1
    UniProtKB/Swiss-Prot
    Q3TQL7, Q3V088, Q80ZN3, Q8C912, Q8CE64, Q9ESV2
    Related
    ENSMUSP00000001092.9, ENSMUST00000001092.15
    Conserved Domains (3) summary
    smart00868
    Location:80 → 156
    zf-AD; Zinc-finger associated domain (zf-AD)
    sd00017
    Location:470 → 490
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:496 → 518
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    123980934..123997290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531227.5 → XP_006531290.1  zinc finger protein 276 isoform X1

    Conserved Domains (3) summary
    smart00868
    Location:80 → 156
    zf-AD; Zinc-finger associated domain (zf-AD)
    COG5189
    Location:321 → 476
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:581 → 601
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_017312923.3 → XP_017168412.1  zinc finger protein 276 isoform X2

    Conserved Domains (3) summary
    smart00868
    Location:80 → 156
    zf-AD; Zinc-finger associated domain (zf-AD)
    COG5189
    Location:321 → 476
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:581 → 601
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_006531229.5 → XP_006531292.1  zinc finger protein 276 isoform X4

    Conserved Domains (2) summary
    smart00868
    Location:80 → 156
    zf-AD; Zinc-finger associated domain (zf-AD)
    COG5189
    Location:321 → 476
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

  4. XM_006531228.5 → XP_006531291.1  zinc finger protein 276 isoform X3

    Conserved Domains (3) summary
    smart00868
    Location:4 → 80
    zf-AD; Zinc-finger associated domain (zf-AD)
    COG5189
    Location:245 → 400
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:505 → 525
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_030243697.2 → XP_030099557.1  zinc finger protein 276 isoform X5

    Conserved Domains (2) summary
    COG5189
    Location:75 → 117
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:222 → 242
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. XR_387763.5 RNA Sequence

    Related
    ENSMUST00000156896.8

  2. XR_001778459.3 RNA Sequence

  3. XR_003947319.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CE64.3 GenPept UniProtKB/Swiss-Prot:Q8CE64

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