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pde4a phosphodiesterase 4A, cAMP-specific [ Danio rerio (zebrafish) ]

Gene ID: 572061, updated on 27-Mar-2024

Summary

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Official Symbol
pde4aprovided by ZNC
Official Full Name
phosphodiesterase 4A, cAMP-specificprovided by ZNC
Primary source
ZFIN:ZDB-GENE-131125-7
See related
Ensembl:ENSDARG00000032344 AllianceGenome:ZFIN:ZDB-GENE-131125-7
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in signal transduction. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Is expressed in oocyte and oocyte stage V. Orthologous to human PDE4A (phosphodiesterase 4A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (46628889..46752569)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (48675971..48800042)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene ribonucleoprotein, PTB-binding 1 Neighboring gene uncharacterized LOC100001908 Neighboring gene si:dkey-248g21.1 Neighboring gene PRKCSH beta subunit of glucosidase II Neighboring gene ELAV like neuron-specific RNA binding protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Role of natriuretic peptide receptor 2-mediated signaling in meiotic arrest of zebrafish oocytes and its estrogen regulation through G protein-coupled estrogen receptor (Gper). Pang Y, et al. Gen Comp Endocrinol, 2018 Sep 1. PMID 29574150
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
XP_005164295.1
XP_009298019.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    46628889..46752569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009299744.3 → XP_009298019.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1

    UniProtKB/TrEMBL
    A0A8M3B8I9, E7FAS0
    Related
    ENSDARP00000024572.6, ENSDART00000006602.8
    Conserved Domains (1) summary
    pfam00233
    Location:403 → 644
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  2. XM_005164238.4 → XP_005164295.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X2

    UniProtKB/TrEMBL
    A0A8M2BBS8
    Related
    ENSDARP00000153858.1, ENSDART00000181358.1
    Conserved Domains (1) summary
    pfam00233
    Location:237 → 478
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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